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The neonatal period of very preterm infants is often characterized by a difficult adjustment to extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors, resulting in poor growth and a high morbidity rate. Long-term multisystem complications include cognitive, behavioral, and motor dysfunction as a result of brain damage as well as visual and hearing deficits

The European Spallation Source (ESS), currently under construction in Lund, Sweden, is a research center that will provide, by 2023, the world's most powerful neutron source. The average power of the proton linac will be 5 MW. Pulsing this linac at higher frequency will make it possible to raise the average total beam power to 10 MW to produce, in parallel with the spallation neutron production, a

Sub-barrier Coulomb excitation was performed on a mixed beam of 62Mn and 62Fe, following in-trap β− decay of 62Mn at REX-ISOLDE, CERN. The trapping and charge breeding times were varied in order to alter the composition of the beam, which was measured by means of an ionisation chamber at the zero-angle position of the Miniball array. A new transition was observed at 418 keV, which has been tentati

This Brief Report reports on the first observation of the β--delayed γ decay of 215Pb, feeding states in 215Bi. The 215Pb beam was produced using resonant laser ionization and mass separated at the ISOLDE-CERN on-line mass separator. This ensured clean identification of the γ rays as belonging to the decay of 215Pb or its β-decay daughters. A half-life of 147(12) s was measured for the 215Pb β dec

We report on the study of excited states in 92,94,96Kr populated via projectile Coulomb excitation at safe energies. The radioactive ion beams at energies of 2.85 MeV/u were delivered by the REX-ISOLDE facility at CERN and impinged on self-supporting 194,196Pt targets. The emitted γ-rays were detected by the Miniball detector-array. A detailed description of the experimental techniques used for ex

Information on β-decay properties of neutron-rich 48-50Ar was obtained at the ISOLDE mass-separator facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass-separation. Normally, argon beams cannot be mass-separated from intense multi-charged symmetric fission krypton and xenon. Several techniques were us

In palaeoclimate reconstructions, the combination of proxy records measured in different climate archives is challenging because of the uncertainties associated with each proxy, but it can also help reduce some of these uncertainties. Here, we present a novel approach to combine speleothem and tree ring proxies for a drought reconstruction of the last 640 years: a fluid inclusion δ18O record from

The neutron-rich nuclei Kr94,96 were studied via projectile Coulomb excitation at the REX-ISOLDE facility at CERN. Level energies of the first excited 2 + states and their absolute E2 transition strengths to the ground state are determined and discussed in the context of the E(21+) and B(E2;21+→01+) systematics of the krypton chain. Contrary to previously published results no sudden onset of defor

The reaction 8Li + 2H has been studied in inverse kinematics at the incident energy of 3.15 MeV/nucleon, using the REX-ISOLDE post-accelerator. The reaction channels corresponding to (d,p), (d,d), and (d,t) reactions populating ground states and low-lying excited states in 7 -9Li have been identified and the related angular distributions extracted and compared with coupled-channels, distorted-wave

We report on one- and two-neutron transfer reactions to study the single-particle properties of nuclei at the border of the "island of inversion". The (d,p)- and (t,p)-reactions in inverse kinematics on the neutron-rich isotope 30Mg, delivered as radioactive beam by the REX-ISOLDE facility, have been investigated. The outgoing protons have been detected and identified by a newly built array of Si

Background: Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment of a minor subgroup of non-small cell lung cancer (NSCLC) patients. Although fluorescence in situ hybridization (FISH) is regarded as the gold standard for detection of ALK rearrangements, ALK immunohistochemistry (IHC) is often used as screening tool in clinical practice. In order to unbiasedly anal

Background: Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis is scarce. We used data from the SEAS trial (Simvastatin Ezetimibe in Aortic Stenosis) to assess what blood pressure (BP) would be optimal. Methods: A total of 1767 patients with asymptomatic aortic stenosis and no manifest atherosclerotic disease were analyzed. Outcomes were all-cause mortality, car

Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundl

The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic and adult stem cell biology were discussed, including their respective niches in ageing, disease and regeneration. Many presentations focused on emerging technolog

Pancreatic cancer is associated with a highly abundant stroma and low-grade inflammation. In the local tumour microenvironment, elevated glucose levels, the presence of tumour-associated stellate cells and macrophages are hypothesised to promote the tumour progression and invasion. The present study investigated the influence by the microenvironment on pancreatic cancer cell invasion in vitro. Aft

Experience of the Port-A-Cath implantable venous access system in 53 children with severe or moderate haemophilia A or B from seven centres in five countries is reviewed. The cumulative duration of follow-up was 1578 months (median 30 months, range 1-114). Of the devices implanted, 70% (37/53) were used without complications (median follow-up 32 months; range 1-114) and the remaining 30% (16/53) w

The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radio