Filtyp
FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational entropy upon ligand binding. Here we report backbone and methyl-axis order parameters of the apo and FK506-bound forms of FKBP12, based on 15N and 2H NMR relaxa
The problem of low-rank approximation with convex constraints, which appears in data analysis, system identification, model order reduction, low-order controller design and low-complexity modelling is considered. Given a matrix, the objective is to find a low-rank approximation that meets rank and convex constraints, while minimizing the distance to the matrix in the squared Frobenius norm. In man
Genom jämförelser mellan beskrivningar och bilder av landskap hos Plinius d.y., Claude Lorrain, Super Mario World och Zelda Skyward Sword undersöker jag hur en serie konventioner rörande blick, avbildande och berättande tillsammans skapar en förståelse av naturen kring oss och ut ur denna producerar ett begripligt landskap.
The negative relationship between birth interval length and neonatal mortality risks is well documented, but heterogeneity in this relationship has been largely ignored. Using the Bangladesh Maternal Mortality and Health Care Survey 2010, this study investigates how the effect of birth interval length on neonatal mortality risks varies by maternal age at birth and maternal education. There is sign
Coastal environments have experienced large ecological changes as a result of human activities over the last 100–200 years. To understand the severity and potential consequences of such changes, paleoenvironmental records provide important contextual information. The Baltic Sea coastal zone is naturally a vulnerable system and subject to significant human-induced impacts. To put the recent environ
The latest discovery of microfossils from the lower Cambrian (Fortunian Stage) Zhangjiagou Lagerstätte in South China are presented. This lagerstätte is rich in exceptionally preserved microfossils, including embryos of Olivooides multisulcatus, Olivooides mirabilis, and Pseudooides prima; hatched stages of O. multisulcatus, O. mirabilis, Hexaconularia sichuanensis, and Quadrapyrgites quadratacris
Bridging the gap between international relations and comparative politics, this book transposes Eurocentric theories and narratives of state-making to new historical and geographical contexts in order to probe their scope conditions. In doing this, the authors question received explanations of the historical origins and geographical limits of state-making, questioning the unilinear view of the eme
Evaniid wasps develop as solitary egg predators within the oothecae of cockroaches. Fossil evaniids are relatively common compared with most other parasitoid Hymenoptera, undoubtedly due to their searching for host cockroaches on tree trunks and thus an increased chance of being trapped in tree resin. The genus Parevania Kieffer, 1907 is widely distributed through the Old World and is also known f
A transmission polarizer for producing elliptically polarized soft X-ray radiation from linearly polarized light is presented. The setup is intended for use at synchrotron and free-electron laser beamlines that do not directly offer circularly polarized light for, e.g., X-ray magnetic circular dichroism (XMCD) measurements or holographic imaging. Here, we investigate the degree of ellipticity upon
Eukaryotic phytoplankton form the basis of aquatic food webs and play a key role in the global carbon cycle. Many of these evolutionarily diverse microalgae are also capable of feeding on other microbes, and hence simultaneously act both as primary producers and consumers. The net ecosystem impact of such mixotrophs depends on their nutritional strategy which is likely to alter with environmental
We describe a class of three Higgs doublet models (3HDMs) with a softly broken U(1) × U(1) family symmetry that enforces a Cabibbo-like quark mixing while forbidding tree-level flavour changing neutral currents. The hierarchy in the observed quark masses is partly explained by a softer hierarchy in the vacuum expectation values of the three Higgs doublets. As a consequence, the physical scalar spe
This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of s=13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb−1, were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of lig
Recension av Elisabet Apelmos nya bok Sport and the Female disabled body
There is scientific evidence of accelerated sea level rise and saline intrusion. Some impacts, such as stratification and estuarine circulation, are subtle; others are dramatic including shifts in salt-sensitive habitats and limited water availability of suitable quality for industrial and municipal uses. These results have become a remarkable reality resulting in a set of integrated surface water
We analyze the microscopic few-body properties of dipolar particles confined in two parallel quasi-one-dimensional harmonic traps. In particular, we show that an adiabatic rotation of the dipole orientation about the trap axes can drive an initially nonlocalized few-fermion state into a localized state with strong intertrap pairing. With an instant, nonadiabatic rotation, however, localization is
Gaseous Electron Multipliers (GEM) are well known for stable operation at high particle fluxes. We present a study of the intrinsic limits of GEM detectors when exposed to veiy high particle fluxes of the order of MHz/mm2. We give an interpretation to the variations of the effective gain, which, as a function of the particle flux, first increases and then decreases. Wre also discuss the reduction
