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Prurigo nodularis (PN) is a chronic, itchy, inflammatory skin condition that negatively affects quality of life. A study was undertaken to investigate the healthcare utilization, including treatment patterns and direct costs for specialist care, for PN in Sweden. Linkage cohorts were created from national Swedish patient and prescription registers, and the cost-per-patient database of PN adults in

Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de

Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients

Background and objective: Prostate cancer (PC) is the second most common cancer and a leading cause of death among males. In this systematic review we evaluated cohort studies and randomized controlled trials (RCTs) on the relationship between dietary patterns and PC risk, progression, mortality, and biomarkers. Methods: A systematic search of MEDLINE, Embase, and Cochrane Central was conducted th

Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr

This study examines the impact of grammatical gender on memory recall among simultaneous bilinguals with two three-gendered languages (Ukrainian and Russian). Ukrainian-Russian bilinguals and English monolingual controls were tested on their ability to remember names assigned to objects with either matching or mismatching grammatical genders across their two languages. Results showed that bilingua

The recognized importance of systemic and dynamic perspectives on both AI and innovation management calls for the retheorization to support the AI technology adoption in innovation management. As extant knowledge about a systems approach to realize dynamic roles of both augmentation and automation of AI-human collaboration in innovation management is limited, this study aims to explore how to leve

This chapter explores the evolution and effectiveness of Sweden's climate policy mix for decarbonizing the transport sector—a major contributor to national greenhouse gas (GHG) emissions. Despite early leadership in climate policy, Sweden faces challenges in aligning policy implementation with ambitious goals, such as a 70 % reduction in transport emissions by 2030. The chapter shows that Sweden's

Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind

Many species are currently experiencing range shifts in response to changing environmental conditions with potentially serious genetic consequences. Repeated founder events and strong genetic drift are expected to erode genetic variation at the range front, reducing adaptive potential and slowing or even halting the expansion. However, the severity of these consequences for common and highly mobil

Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo

Unlike glucose, the sub-optimal xylose utilization in recombinant Saccharomyces cerevisiae strains may stem from an unusual signaling response that is not adapted to detecting xylose as a fermentable substrate. We hypothesize that the membrane receptor Snf3p, known for sensing extracellular low glucose levels, may contribute to xylose recognition. To test this, we explored the effect of SNF3 inact

Vocabularies of space define the world. Yet, despite their apparent conceptual authority (Harley 1989), the lineagesof cartographic entities are often blurred, accidental, and produced from etymologies only imperfectly understoodby their users. Drawing on a recent study on past and present meanings of the term ‘Mesopotamia’ (Rattenborg2018), this paper reviews the inadvertent, if now firmly embedd

Historical sources written in rare or undeciphered scripts represent an immense but underexploited part of the world’s cultural and linguistic heritage. Their study is often hindered by fragmentary preservation, non-standard symbol systems, and the absence of interoperable digital resources. While recent advances in imaging, transcription, and computational analysis have improved access to histori

Background: Autoantibodies against β-cell components in the pancreatic islets of Langerhans are characteristic of type 1 diabetes (T1D). The genetic and autoimmune determinants of type 1 diabetes (T1D) in Ethiopians are not yet thoroughly characterized, with studies indicating a lower occurrence of autoantibodies related to T1D compared to Caucasians. The study aimed to determine the occurrence of

Background: The study aimed to analyze thyroid-stimulating hormone (TSH) levels quantitatively and investigate their potential correlation with the risk of incident atrial fibrillation (AF) in differentiated thyroid cancer (DTC) patients. Methods: DTC cases diagnosed between 1995 and 2015 in Stockholm, Sweden, were identified from the Swedish Cancer Registry. Medical records were scrutinized, and

A major target of the Marxist critique of “post-theory”—a broad term encompassing post-structuralism, post-Marxism, and postcolonial theory—has been its notorious deconstruction of the subject. The affirmation of marginal, excluded, and deviant subject positions within the same corpus has been noted less frequently. To recalibrate the Marxist critique of post-theory to also encompass its affirmati

Loess-palaeosol sequences (LPS) are among the most continuous terrestrial archives of Quaternary climate change. Their widespread distribution, high accumulation potential, and sensitivity to environmental variability make them critical for reconstructing past dust fluxes, wind regimes, and regional ecosystem responses. However, the reliability of such reconstructions is fundamentally constrained