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DNA-encoded chemical libraries (DECLs) have become integral to early-stage drug discovery, yielding active compounds and extensive labeled datasets for machine learning (ML)-based prediction of bioactive molecules. However, the information content of DECL selection data remains scarcely explored. This study systematically investigates for the first time the prevalence of false negatives and the in
Individuals with immigrant background generally perform less well in school than non-immigrants. Performing well in school may decrease the risk of substance use disorder (SUD). We investigated whether higher school performance is associated with a decreased risk of SUD in early adulthood among immigrants and non-immigrants and whether subsequent educational attainment and employment status partly
By age 40 years, over 90% of adults with Down syndrome have Alzheimer's disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with Down syndrome have elevated cerebrovascular disease markers that track with the clinical progression of Alzheimer's disease, suggesting a role of cerebrovascular disease that is hypothesized to be mediated by in
Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genet
BACKGROUND: Balloon-guide catheters (BGC) have been associated with improved procedural and functional outcomes following endovascular thrombectomy (EVT) in multiple observational studies. Recently the PROTECT-MT trial challenged this benefit, showing worse functional outcomes when using BGCs. This study aims to assess the association between BGC-use and procedural and functional outcomes in a lar
BACKGROUND: Nimodipine improves outcome after aneurysmal subarachnoid hemorrhage (aSAH) through mitigation of delayed cerebral ischemia (DCI). Most studies are based on a treatment duration of 21 days. At our institution, clinical practice is to administer nimodipine for 14 days, regardless of bleeding severity. Treatment is prolonged if signs or symptoms of DCI occurs. The present study aims to r
INTRODUCTION: Tourette syndrome (TS) and chronic motor or vocal tic disorder (CTD) are neurodevelopmental disorders associated with functional impairment and reduced quality of life. Behavioral therapy (BT) is an effective treatment, but lack of experienced practitioners makes it hard for patients to receive appropriate help. One approach to bridge the gap between demand and availability is to off
AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME
Objective: To design a dynamic prediction model for estimating the time of progression from a single glutamic acid decarboxylase autoantibody (GADA) to multiple islet autoantibodies and type 1 diabetes in children, exploring different longitudinally measured risk variables. Research Design and Methods: GADA-positive children (n = 379) participating in The Environmental Determinants of Diabetes in
Background: The transition to sustainable energy systems requires a deeper understanding of how households experience and negotiate heating practices over time. In Sweden, where residential heating remains a major source of energy use, heating systems are embedded in daily routines, shaped by evolving technologies, social norms, and material contexts. This study draws on the Energy Cultures Framew
Syftet med denna rapport är att belysa potentialen i offentlig upphandling, för att främja ett mer inkluderande och jämställt näringsliv, genom att stärka kvinnors företagande i Sverige. Offentlig upphandling är ett betydande verktyg för den offentliga sektorn, inte bara för att anskaffa varor, tjänster och entreprenader, utan också som ett potentiellt styrmedel för att uppnå samhällspolitiska mål
Radionuclide therapy involving 177Lu-labelled somatostatin analogues for the treatment of neuroendocrine tumours isincreasing. While the treatment is currently administered according to a standard protocol, patient-specific treatmentsbased on dosimetry are believed to be beneficial. However, commonly adopted dosimetry procedures are lacking, andlocally developed dosimetry methods are used, which mRadionuclide therapy involving 177Lu-labelled somatostatin analogues for the treatment of neuroendocrine tumours isincreasing. While the treatment is currently administered according to a standard protocol, patient-specific treatmentsbased on dosimetry are believed to be beneficial. However, commonly adopted dosimetry procedures are lacking, andlocally developed dosimetry methods are used, which m
I en tid då verkningarna av den tredje industriella revolutionens utveckling av informationsteknologi utmanar vårt beskattningssystem har den fjärde industriella revolutionen redan inletts. Parallellt med de svårigheter som följer av att försöka fastställa var en digital närvaro ska beskattas står vi inför en samhällsomdanande strukturomvandling, där ökad automatisering pådriven av artificiell int
I takt med att generativ AI har blivit både bättre och mer lättillgänglighar skriftliga examinationsformer såsom uppsatser och hemtentamenbörjat ifrågasättas. Med stöd i den traditionella synen på generativ AIsom ett otillåtet hjälpmedel, där studenten genom tekniken inte självformulerar de skriftliga inlämningarna som ska bedömas, beklagar siglärarkollegor över hur skrivuppgiften urholkas och ris
As international cross-border tax planning increasingly tests domestic legal frameworks,Sweden has relied on a patchwork of different provisions to combat treaty abuse. Throughthe dynamic interplay between its domestic anti-avoidance rules and international treatyprovisions, Sweden has occasionally deployed its targeted Specific Anti-Avoidance Rules(SAARs) and even discussed the possibility of app
This thesis offers a comprehensive account of the emergence and evolution of Maumaus—an art organisation dedicated to education, curation, and production founded in Lisbon in 1992. Through an analysis of its history and the values and principles that underpin its programmes, this (auto)biography of the organisation—produced by a practitioner who is himself inextricably bound in this history—conduc
This paper presents a novel convolutional neural network (CNN)-based control chart for detecting localized and subtle speckle shifts (displacements) in the images. To enhance detection accuracy, especially in detecting localized and simultaneous shifts, we design a custom CNN architecture and utilize a training methodology. Moreover, instead of inputting the entire images, we divide them into equa
