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Importance Cold knife conization (CKC) and the loop electrosurgical excision procedure (LEEP) are standard treatments for cervical intraepithelial neoplasia and carcinoma in situ. However, the comparative long-term effectiveness of these procedures in promoting human papillomavirus (HPV) clearance and preventing recurrent cervical lesions remains uncertain. Objective To compare the long-term incid
Self-supervised pre-training based on next-token prediction has enabled large language models to capture the underlying structure of text, and has led to unprecedented performance on a large array of tasks when applied at scale. Similarly, autonomous driving generates vast amounts of spatiotemporal data, alluding to the possibility of harnessing scale to learn the underlying geometric and semantic
Elevated atmospheric CO2 concentration (eCO2) is expected to substantially exacerbate Compound Drought and Heatwave (CDHW) events, posing increasing risks to ecosystems and human society. However, the role of land-atmosphere interactions in regulating CDHW events under eCO2 remains poorly understood. Here we investigated the contribution of land-atmosphere interactions to the global intensificatio
Telomere length (TL) has been proposed as a marker of appendicular lean mass (ALM) decline; however, longitudinal evidence remains limited. We aimed to investigate the longitudinal association between TL and 6-year trajectories of ALM. This longitudinal study included 185 older adults aged 55–75 years with overweight or obesity and metabolic syndrome at baseline. Baseline TL was assessed using a m
This essay examines how R. A. Markus and Erik Peterson conceptualize law and political authority. Both Catholic converts reject the Aristotelian view of the human being as fundamentally a political animal. Instead, they articulate an eschatological anthropology in which law and politics emerge from the Fall: necessary under present conditions yet ultimately ordered toward redemption. Markus, drawi
I den här studien utvärderar vi geologiska arkiv och ett flertal geologiska metoder för att identifiera och datera historiska stormflodshändelser längs Hallands kust. Vi har också undersökt en lokal vid Löderup i Skåne som påverkats av en modern stormflod under stormen Babet hösten 2023. Genom fjärranalysbaserat platsurval, fältarbete samt olika laboratorieanalyser inklusive dateringsmetoder testaThis study evaluates geological archives and a suite of proxy methods to identify and date past storm-surge events along the Halland coast, southwest Sweden, with a modern analogue site at Löderup in Scania. Using GIS-based site selection, targeted fieldwork and laboratory analyses including dating methods, we tested which coastal settings and methods best record overwash deposits and whether the
Gastrointestinal (GI) cancers represent a significant global health burden, characterized by high incidence, poor prognosis, and limited response to monotherapies. The advent of bispecific antibodies (BsAbs) has introduced a novel therapeutic paradigm, enabling dual targeting of tumor-associated antigens and immune effectors to enhance antitumor immunity. This review provides a comprehensive overv
The estimation of the number of defective tendons in post-tensioned concrete bridges is a key input for the reliability assessment of prestressed girders. However, special inspection methods for detecting voids and assessing tendon condition are intrusive, time-consuming, and costly, and the quantitative definition of an inspection sample size that meaningfully reduces epistemic uncertainty while
As existing transport infrastructure continues to age and traffic demand rises, there is a growing urgency to reduce emissions. In this context, extending the service life of infrastructure emerges as a key strategy. This paper introduces a basic decision-analytical approach to infrastructure service life extension with an integrated model basis. The model basis facilitates the joint assessment of
This paper presents a probabilistic approach for updating the structural reliability of reinforced concrete structures using chloride concentration measurements. Beyond well-known approaches, the proposed method accounts for uncertainties in both the chloride ingress model and measurements. It preserves temporal consistency by updating depth-specific chloride concentrations and time-specific diffu
The rate of energy turnover in an animal, metabolic rate, is fundamental to life and determines the energy available for growth, reproduction, and survival. Thus, metabolic rate has been proposed as a mechanism linking physiology to broader ecological patterns. Numerous adaptive frameworks have been proposed to explain how selection acts on metabolic rate, how it relates to life histories, and the
Social norms, institutional weaknesses, and gaps between policy commitments and implementation in Malawi continue to pose significant barriers to adolescents’ realisation of their sexual and reproductive health and rights (SRHR). Early marriage, gender-based violence, and limited access to contraception and comprehensive sexuality education (CSE) undermine adolescents’ wellbeing and future opportu
The European Spallation Source in Lund, Sweden, is the next generation neutron research facility that will provide unprecedented capabilities for particle physics as well as materials and life science research through its high brightness, long-pulse neutron source and advanced instrument suite. To fully benefit from and to contribute to the build up of this facility, Swedish researchers are engage
