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Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a model for studies of lipid-associated disorders,
Self-Adaptive Systems (SAS) and Cyber-Physical Systems (CPS) have received significant attention in recent computer engineering research. This is due to their ability to improve the level of autonomy of engineering artefacts. In both cases, this autonomy increase is achieved through feedback. Feedback is the iteration of sens- ing and actuation to respectively acquire knowledge about the current s
Given the recent surge in SARS-CoV-2 Omicron infections, we performed a quantitative PCR screening survey during June 28-29, 2022, in Stockholm, Sweden, to investigate SARS-CoV-2 point prevalence in a group with high exposure risk. Results showed SARS-CoV-2 infection in 2.3% of healthcare workers who were asymptomatic at time of sampling.
Neurodegenerative disorders (NDDs) such as Huntington's disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable populations of neurons. Although often associated with motor impairments, these NDDs share several commonalities in early symptoms and signs that extend beyond motor dysfunction
Background: There has been growing interest around integrating palliative care (PC) into emergency department (ED) practice but concern about feasibility and impact. In 2020, as the COVID pandemic was escalating, our hospital's ED and PC leadership created a new service of PC clinicians embedded in the ED. Objectives: To describe the clinical work of the embedded ED-PC team, in particular what was
Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut microbiota composition or dose-manner effects on the intestinal integrity of healthy tissue have not been evaluated. In this study, C57BL/6 young, healthy mice were fed bromelain or papain in a dose
Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic
This paper revisits the development of the canonical Swedish wage bargaining model, from the 1930s to the 1950s. The question at the core of the debate is: how did Sweden achieve “good” wage bargaining institutions -- good, in the sense of facilitating investment, employment, and controlled inflation? The conventional account focuses on the actions of employers and trade unions in export industry,This paper revisits the development of the canonical Swedish wage bargaining model, from the 1930s to the 1950s. The question at the core of the debate is: how did Sweden achieve “good” wage bargaining institutions -- good, in the sense of facilitating investment, employment, and controlled inflation? The conventional account focuses on the actions of employers and trade unions in export industry,
Part of the Northern Hemisphere has experienced widespread autumn cooling during the most recent decades despite overall warming, but how this contrasting temperature change has influenced the ecosystem carbon exchange remains unclear. Here, we show that autumn cooling has occurred over about half of the area north of 25° N since 2004, producing a weak cooling trend over the period 2004–2018. Mult
Interannual variability of the terrestrial ecosystem carbon sink is substantially regulated by various environmental variables and highly dominates the interannual variation of atmospheric carbon dioxide (CO2) concentrations. Thus, it is necessary to determine dominating factors affecting the interannual variability of the carbon sink to improve our capability of predicting future terrestrial carb
Studying migrants from Sweden to the United States, we provide new evidence on return migration during the Age of Mass Migration. Focusing on a sample of migrants and stayers observed in childhood, we document limited effects on income and occupational upgrading, but large effects on wealth. Male returnees held about twice as much wealth as stayers and about 40 percent more than staying brothers.
A garden G is populated by n≥1 bamboos b1,b2,...,bn with the respective daily growth rates h1≥h2≥⋯≥hn. It is assumed that the initial heights of bamboos are zero. The robotic gardener maintaining the garden regularly attends bamboos and trims them to height zero according to some schedule. The Bamboo Garden Trimming Problem (BGT) is to design a perpetual schedule of cuts to maintain the elevation
Data analytics is regarded as an important function of 5G networks. The Network Data Analytics Function (NWDAF) is standardized in 3GPP to enhance 5G network performance by analyzing data from network functions and user equipment. Abnormal behavior detection, which is part of the NWDAF framework, has the potential to be a powerful tool to improve 5G network security. Despite this, only limited res
A number of instruments measuring psychological outcomes of falling exist, e.g. the Falls Efficacy Scale (FES). An extended version of the FES, the Falls Efficacy Scale-International (FES-I), has been developed and translated into several European languages. The aims of this study were to evaluate internal reliability, examine the internal structure of the FES-I(S) (the Swedish version of the FES-
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerge. However, expression of transposable elements can be pathogenic and is therefore tightly controlled. KRAB domain-containing zinc finger proteins (KRAB-ZFPs) recruit the co-repressor KRAB-associated protein 1 (KAP1/TRIM28) to regulate many transposable elements, but how KRAB-ZFPs and KAP1 interact
Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative ph
We investigate the fragmentation dynamics of adamantane dications produced after core-ionization at the carbon edge followed by Auger decay. The combination of high-resolution electron spectroscopy, energy-resolved electron-ion multi-coincidence spectroscopy and different theoretical models allows us to give a complete characterization of the processes involved after ionization. We show that energ
In this paper, I put forward an argument that sustainability science can make objectively grounded normative claims about what courses of action society should pursue in order to achieve sustainability. From a survey of the philosophy of science, social theory and sustainability science literature, I put forward an approach to justifying these normative arguments. This approach builds on the insig
