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Aim: We aimed to study the feasibility and tolerability of a combination therapy consisting of glutamic acid decarboxylase (GAD-alum), Etanercept and vitamin D in children and adolescents with newly diagnosed with type 1 diabetes (T1D), and evaluate preservation of beta cell function. Material and Methods: Etanercept Diamyd Combination Regimen is an open-labelled multi-centre study pilot trial whi

AIMS: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. METHODS AND RESULTS: We included 100 patients with a definite ARVC diagnosis according

Land ecosystems contribute to climate change mitigation by taking up approximately 30% of anthropogenically emitted carbon. However, estimates of the amount and distribution of carbon uptake across the world's ecosystems or biomes display great uncertainty. The latter hinders a full understanding of the mechanisms and drivers of land carbon uptake, and predictions of the future fate of the land ca

The thesis explores the ‘missing link’ in the study of priority-setting for research, development, and innovation (RDI), namely the processes of implementing RDI priorities, and the consequences of these processes. It does so by focusing on how choices, actions, and motivations of implementers of RDI priorities established elsewhere in the policy system enact, or carry out, the priorities, resulti

Background: The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based on patient reported data. Method: A logic model framework was used to describe the process of development and implementation of a structured plan for evaluation of PBT for all diag

Popular Abstract in Swedish 2003 års Nobelpris i kemi gick till professor Peter Agre för upptäckten av aquaporinerna. Aquaporiner är proteiner som sitter i membran och bildar kanaler som tillåter vatten och andra små neutrala molekyler att passera genom membranet. Aquaporinerna utgör en mycket gammal och välkonserverad proteinfamilj som finns i alla levande organismer som hittills undersökts. VäxAquaporins, or Major Intrinsic Proteins (MIPs), are integral proteins that facilitate transport of water and other small neutral solutes across biological membranes. They belong to a well conserved and ancient family of proteins, present in all organisms ranging from bacteria to plants and humans. The aquaporin family in plants is large, indicating complex and regulated water transport within the

Semiconductor nanowires are nanoscale objects formed by bottom-up synthesis. In recent years their unique properties have been exploited in fields such as electronics, photonics, sensors and the life sciences. In this work, the epitaxial growth of nanowires and their applications were studied. Heteroepitaxial growth of III-V nanowires on silicon substrates was demonstrated. This may enable direct

Purpose The research presented is the initial part of a project with the aim of increasing the use of end-user requirement through out the construction process. This initial part maps how Swedish real estate companies manage end-user requirements and evaluate the outcome. Methodological approach The focus of the study was on methods for capturing and managing end-user requirements and for measur

För mindre och nystartade aktiebolag kan finansiering vara ett gissel, särskilt om den verksamhet som bedrivs i bolaget är kostsam eller förenad med hög finansiell risk för potentiella finansiärer. Sådan är situationen ofta i det som i folkmun kallas ”startups”, då bolagen frekvent bygger på enbart en idé eller en outvecklad produkt, och därmed utgör mycket osäkra investeringar för poten- tiella fFunding for a small or newly established limited company can be difficult, especially if the operating objective in the company is associated with high costs and high financial risks for potential financiers. This is often the case for so called “start-ups”, as these types of companies are frequently based on an idea or an undeveloped product. Investing in a start-up is very risky for pot- ential

En kall eftermiddag den 23 december 1947 hände något fantastiskt på ett laboratorium i New Jersey, USA. Forskare vid Bell laboratoriet demonstrerade för första gången en funktionell transistor! Transistorn är en elektrisk komponent som har tre terminaler där man kan ansluta andra komponenter. Om man leder en ström eller spänning genom ett par av terminalerna kan man kontrollera strömmen genom ett As the limits of transistor feature size scaling is reaching its saturation, new innovations are needed to prevent performance loss. High performance transistors on the III/V semiconductor platform implemented with ferroelectric oxides might in the future satisfy this demand. But the integration of ferroelectrics on materials such as InAs degrades the substrate and other vital components from the

En ökad medvetenhet om värdet av ett rent grundvatten yttrar sig i allt fler sammanhang, bl.a. i det nationella miljömål om grundvatten av god kvalitet som riksdagen presenterat. Simrishamns kommun ser över vattenskyddsområdena runt kommunens grundvattentäkter för att säkerställa ett rent grundvatten. Målet med detta examensarbete är att ta fram ett underlag som skall kunna ligga till grund för avThe increased awareness of the value of clean groundwater can be seen in a growing number of contexts. This is also emphasized in the national environmental goals, put up by the Swedish government. The municipality of Simrishamn, in southern Sweden, is re-evaluating the extension of the existing restriction areas around the groundwater wells of the municipality. The aims in this investigation were

This Master Thesis describes the product development of a medical laboratory machine. The purpose of the project was to generate and evaluate different concepts of a device that is to be included in a bigger process named Dried Blood Spot testing (DBS) in which dried blood samples are collected and analyzed. The device developed here shall relocate the blood samples from a paper slip, mounted on a

The field of Cognitive Psychology has discovered a large number of automatic and systematic errors of judgement that humans make. These are called cognitive biases and cause irrational behavior in diverse contexts. Prior research has found that cognitive biases can cause irrational behavior in companies. For example company functions, such as planning, have been found to suffer from systematic err

Dagens krav på läkemedel är höga, de ska t.ex. stanna kvar i kroppen under lång tid, ha lång hållbarhetstid och vara lätt att dosera. Att PEGylera ett läkemedel kan ge dessa egenskaper. Idag är dock denna tillverkningsprocess långsam och ger ett lågt utbyte. Size Exclusion Reaction Chromatography (SERC) är en ny teknik som förhoppningsvis ska förbättra denna process. Protein är idag vanligt förekoThe PEGylation process is a covalent attachment between a protein (the pharmaceutical) and poly ethylene glycol (PEG) and since the beginning in 1977 PEGylation processes have been used to improve pharmaceuticals. PEGylation of a pharmaceutical achieves improved properties like greater solubility in water, longer residence time in vivo and extended shelf life. The PEGylation process is in general

Produktion av en nanotrådssolcell För att ta itu med miljöpåverkan från växthusgaser krävs en övergång till förnyelsebara energikällor. Ett exempel på en sådan källa är nanotrådssolceller. I mitt examensarbete har jag undersökt hur nanotrådar kan arrangeras på sådant sätt som krävs för att kunna omvandla solljuset till elektricitet. Global uppvärmning är ett hot som till stor del orsakas av utslThe demand for cheaper and more efficient solar cells is high. One way to decrease cost of material, while maintaining a high degree of efficiency, is to take advantage of nanomaterials. A thin film containing pn-junction nanowires can convert light with an efficiency comparable to traditional planar cells, while using a fraction of the material, and thus reduce costs. At the company Sol Voltaics

För att begränsa den globala uppvärmningen krävs en omställning mot en klimatmässigt hållbar livsmedelsförsörjning. Konsumtionen av kött och mejeriprodukter, som idag står för en stor andel av matens klimatpåverkan, behöver minska till förmån för mer resurseffektiva vegetabiliska livsmedel. För att kunna komplettera eller ersätta animaliska näringskällor berikas många växtbaserade produkter med inIn order to mitigate the global warming, a transition towards a sustainable diet is required. Such a transition includes reduced consumption of meat and dairy products, by substituting these with more resource efficient vegetable-based products. In order to meet the nutrient content of animal foods, vegan products are often supplemented with artificial vitamins and minerals. Few studies have inves

Bakgrund: Till följd av att den globala konkurrensen tilltar, ökar komplexiteten, flexibiliteten och produktvariationen inom produktion. Detta leder till att förbättringsprojekt blir allt svårare att genomföra. Händelsestyrd simulering har i litteraturen blivit identifierat som ett verktyg med förmågan att lösa dessa utmaningar, men till följd av att komplexiteten i en produktion ökar, växer ocksåBackground: Following a growing global competition, complexity, flexibility and product variability of manufacturing systems are increasing. This has led to improvement projects becoming more difficult to carry out. Discrete event simulation (DES) has in literature been identified as having the capability to solve these challenges, but as complexity of a manufacturing system increases so does also

Lesbian, gay, and bisexual people continue to face discrimination and persecution in their daily lives, often from both the state and their communities. Where states do not provide for the basic human rights and physical security of their lesbian, gay, and bisexual citizens, many such citizens would flee their countries of origin in search of refuge in more hospitable countries. If other countries

Course: FEKH29 Business Administration: Bachelor thesis in Marketing, Undergraduate Level, 15 ECTS Authors: Sophie Jensen, Annika Klaus, Fredrik Ohlsson Advisor: Clara Gustafsson Key words: Loyalty, Loyalty program, consumer behavior, impact & customer club Purpose: The purpose of this study is to improve the understanding of how a younger target group respectively an older target group in