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Popular Abstract in Swedish Diabetes mellitus är en samling sjukdomar som karaktäriseras av förhöjt blodsocker. Traditionellt har man delat upp sjukdomen i två former; typ 1 och typ 2 diabetes. Vid typ 1 diabetes förstörs de insulinproducerande β-cellerna i bukspottskörteln av kroppens immunförsvar och sjukdomen debuterar ofta tidigt i livet. Typ 2 diabetes, tidigare ofta benämnd ”åldersdiabetes” Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. However, the role of 5-HT in control of insulin rel

Bell’s palsy is an acute onset of peripheral facial nerve dysfunction. Despite extensive research the aetiology is unclear. The most prevailing theory is that reactivation of viruses such as Herpes simplex type-1 or Varicella zoster may cause Bell’s palsy. The natural course is favourable but at least 30% of patients will suffer sequelae such as residual paresis, synkinesis and/or contracture. The

Atmospheric aerosol samples from a boreal forest (Hyytiala, April 2007), a rural site in Hungary (K-puszta, summer 2008), a polluted rural area in Italy (San Pietro Capofiume, Po Valley, April 2008), a moderately polluted rural site in Germany located on a meadow (Melpitz, May 2008), a natural park in Spain (Montseny, March 2009) and two urban background locations (Zurich, December 2008, and Barce

When a child is diagnosed with diabetes, the symptoms may be in its most severe form with ketoacidosis, to mild symptoms of diabetes, detected incidentally. Moderate and severe symptoms of diabetes presentation require infusion therapy and thereby necessitate hospitalisation for the first few days. The initial management is largely a preparation for family members to help them gain the practical u

Optical spectroscopy has been used as a supplement to conventional techniques for analyzing and diagnosing cancer in many human organs. Because ocular tumors may be characterized by their different melanin content, we investigated the feasibility of using transscleral visible/near-infrared spectroscopy (Vis/NIRS) to estimate the quantity of melanin in a novel uveal melanoma phantom of ex vivo porc

The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic and cholinergic regulatory projection systems degenerate, but the exact pathways th

Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)

Popular Abstract in English The word “motion” usually brings to mind movement from point A to point B. In the world of chemistry, this kind of motion is typically referred to as translational motion. Its consequences are experienced by us every time we smell a scent in the air or watch a dye spread in water. The fragrance is nothing else than molecules that fly in the air. Colour is molecules swimThe work presented in this thesis is dedicated to theoretical development, experimental testing and application of polarization transfer solid-state nuclear magnetic resonance (PT ssNMR). PT ssNMR is an analytical tool which provides detailed information about molecular mobility in model or simple soft matter systems at the low water content regime, enabling the creation of phase diagrams. Soft ma

Ectomycorrhizae is a mutualistic association between roots of woody plants and a diverse range of soil fungi. The fungi exchange soil derived mineral nutrients for photosynthetic sugars from the host plant. The mycorrhizal symbioses are commonly found in all forest ecosystems and have a major ecological and economical importance. I have used comparative genomics, DNA microarrays and computational

Binding of calcium to the protein calmodulin leads to molecular reorganization that enables interaction with target peptides and activation of downstream processes. I have studied the dynamics of the calcium-loaded form of a C-terminal calmodulin mutant (E140Q-Tr2C) using NMR spin relaxation experiments. E140Q-Tr2C exhibits global conformational exchange on the microsecond time-scale. The populati

Den 27 oktober 2006 meddelade den engelska appellationsdomstolen (UK Court of Appeal) ett vägledande avgörande i de s.k. Aerotel/Macrossan-avgörandena. Domen relaterade till två mål som berörde tolkningen av det patenterbara området enligt sektion 1 (2) i den engelska patentlagen (Patent Act 1977), vilken motsvarar art. 52 i den Europeiska Patentkonventionen (EPC). Det första målet gällde ett isra

Popular Abstract in Swedish Populärvetenskaplig sammanfattning av avhandlingen "Invading Herbivory. Effects of the Golden Apple Snail (Pomacea canaliculata) in Asian wetlands". 1980 förde några affärsmän ett okänt antal individer av den sydamerikanska vattensnäckan Pomacea canaliculata till Taiwan. Snäckorna skulle odlas i dammar och säljas som människoföda på marknader i Asien och överskottet skThe South American golden apple snail (Pomacea canaliculata) was intentionally introduced to aquacultures in South East Asia to produce snails for human consumption, but the aquatic snails soon escaped and started to consume large amounts of rice seedlings. The aim of this thesis was to quantify the effects of this invasive herbivore on aquatic plants in natural wetlands since previous research h

PURPOSE: We measured serum levels of human glandular kallikrein 2 (hK2) in patients with prostate cancer treated with radical retropubic prostatectomy for clinically localized prostate cancer to determine whether preoperative hK2 levels discriminate stage pT2a/b from pathological stage T3a or greater cancer. This finding would help to predict preoperatively the organ confined versus non-organ conf

Popular Abstract in Swedish Den fysiska planeringen innebär interaktion mellan aktörer inom skilda samhällssfärer där parter med skilda sociala positioner, resurser, perspektiv och värderingar möts. Aktörernas bilder av vilka effekter ett givet planförslag medför och vilka effekter som ska betraktas som de mest centrala varierar regelmässigt. Mellan de berörda parterna är det därför inte ovanligt Since planning in connection with new building projects frequently generates controversy, it can be seen as a typical form of contentious politics. The aim of this dissertation is to analyze siting controversies, their origin, development and termination, in efforts to explore the problem of legitimacy in planning processes of this sort. The research approach employed is that of a multiple case s

Popular AbstractDen nya världsordningen som Castells kallar för nätverksamhälle skapar en konflikt mellan globalisering och identitet. I detta avseende blir frågan om identitet och etniska gränser, i Barths mening, ett centralt tema för att förstå samhällsförändringar. Globaliseringsprocessen håller på att skapa en försvagning av det civila samhället och med detta försvagas också förhållandena melThe new world order, that Castells denominates network society, generates a conflict between the globalisation and identity. In this sense the questions of identity and ethnic boundaries,in Barth’s meaning, emerge as a central subject to understanding societal changes. Globalisation is causing a weakening of the civil society, the relationship between the nation state and the people is also debili

Objective: Needle acupuncture in small children has gained some acceptance in Western medicine. It is controversial, as infants and toddlers are unable to consent to treatment. We aimed to assess its efficacy for treating infantile colic. Design: A systematic review and a blinding-test validation based on individual patient data from randomised controlled trials. Primary end-points were crying tim

Background: Current guidelines for initial management of traumatic brain injury (TBI) support decision making, but they are rarely validated. The Scandinavian guideline for management of children with TBI (SNC16) was developed to minimise the use of cranial computed tomography (cCT) without compromising safety, but the performance of the guideline in a real-world population is unknown. We aimed to

Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that ha

Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte

The recent decades have been characterised by a trend where the public sector's been inspired by several methods and strategies from the private sector. The public library is in this case no exception. In this context there are different perspectives on whether or not this will lead to a dramatic change of the role and values of the traditional public library. The aim of this master's thes