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Metal binding to Bacillus subtilis ferrochelatase and interaction between metal sites.
Protein Kinase Cepsilon Actin-binding Site Is Important for Neurite Outgrowth during Neuronal Differentiation.
We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi
Developing an empirical model of stand GPP with the LUE approach: analysis of eddy covariance data at five contrasting conifer sites in Europe
This paper develops a statistical model for daily gross primary production (GPP) in boreal and temperate coniferous forests. The model applies the light use efficiency (LUE) approach, which estimates the conversion efficiency of daily absorbed photosynthetically active radiation (APAR) into daily GPP as a product of potential LUE and modifying factors. The latter were derived from daily total APAR
Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor
Sustained intravascular exposure to propofol does not prolong pain at the site of injection
Theoretical study of structure of catalytic copper site in nitrite reductase
The active-site cysteinyls and hydrophobic cavity residues of resA are important for cytochrome c maturation in Bacillus subtilis
Nest-site selection and predation in Savi’s Warblers, Locustella luscinioides.
Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site.
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
The platelet-derived growth factor (PDGF) ß receptor mediates mitogenic and chemotactic signals. Like other tyrosine kinase receptors, the PDGF ß receptor is negatively regulated by protein tyrosine phosphatases (PTPs). To explore whether T-cell PTP (TC-PTP) negatively regulates the PDGF ß receptor, we compared PDGF ß receptor tyrosine phosphorylation in wild-type and TC-PTP knockout (ko) mouse em
Interaction of serum amyloid A with human cystatin Cuidentification of binding sites
Serum amyloid A (SAA) is a multifunctional acute-phase protein whose natural role seems to be participation in many physiologic and pathological processes. Prolonged increased SAA level in a number of chronic inflammatory and neoplastic diseases gives rise to reactive systemic amyloid A amyloidosis, where the N-terminal 76-amino acid residue-long segment of SAA is deposited as amyloid fibrils. Rec
Comparison of the active-site design of molybdenum oxo-transfer enzymes by quantum mechanical calculations.
Macronutrients in tree stems and foliage: a comparative study of six temperate forest species planted at the same sites
D5.3: Data Collected from Case Study Sites : WP5 Case studies
Mapping the ribosomal protein S7 regulatory binding site on mRNA of the E. coli streptomycin operon
Selection of random RNA fragments as method for searching for a site of regulation of translation of E. coli streptomycin mRNA by ribosomal protein S7
In E. coli cells ribosomal small subunit biogenesis is regulated by RNA-protein interactions involving protein S7. S7 initiates the subunit assembly interacting with 16S rRNA. During shift-down of rRNA synthesis level, free S7 inhibits self-translation by interacting with 96 nucleotides long specific region of streptomycin (str) mRNA between cistrons S12 and S7 (intercistron). Many bacteria do not
Do passerine migrants captured at an inland site perform temporary reverse migration in autumn?
Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography
Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b
