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Luminiscensdatering är en väletablerad dateringsmetod inom geologisk och arkeologisk forskning. Dock är användandet av luminiscensdatering, mer specifikt optiskt stimulerad luminiscens (OSL), fortfarande underrepresenterat inom norsk arkeologi. Denna studie ämnar utreda lämpligheten av denna dateringsmetod som ett användbart alternativ för utgrävningar av Stenålderslokaler på den norska kusten. De

Cultural tourism and cultural heritage management, while distinct disciplines with differing foci, are also inherently intertwined. However, conflicts between the two often arise due to the diverse number of stakeholders and interests involved in either the travel industry or the conservation and protection of cultural heritage. Despite this, cultural tourism can greatly benefit the conservation o

Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than

ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances catalysis by the catalytic protein HisGS while mediating allosteric inhibition by histidine. Activation by HisZ was proposed to position HisGS Arg56 to stabilise departure of the pyrophosphate leaving group. Here we report

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we fo

Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Despite extensive research effort, neither the catalytic nor the inhibition mechanisms of MAO have been completely understood. There has also been dispute with regard to the protonation s

We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi