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Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu

In this study, we assess the impact of an image restoration pipeline, designed for digital mammography, on the detectability of microcalcifications of different sizes across varied radiation exposures. The restoration pipeline first removes the noise of the image considering a Poisson-Gaussian noise model that incorporates quantum and electronic noise. Then, it appropriately merges the noisy and d

BACKGROUND: Despite pain control being a top priority in end-of-life care, pain continues to be a troublesome symptom and comprehensive data on pain prevalence and pain relief in patients with different diagnoses are scarce.METHODS: The Swedish Register of Palliative Care (SRPC) was used to retrieve data from 2011 to 2022 about pain during the last week of life. Data were collected regarding occur

Purpose: The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend using highly malignant electroencephalogram (EEG) patterns (HMEP; suppression or burst-suppression) at > 24 h after cardiac arrest (CA) in combination with at least one other concordant predictor to prognosticate poor neurological outcome. We evalu

The discussion of the digital divide and digital inclusion has extended to older adults. Although knowledge on the digital divide and digital inclusion among native older adults has increased substantially, little is known about the situations of older immigrants in relation to the digital divide. This paper employed the scoping review approach to map the situations and research methods of the dig

Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. B

Purpose: To compare the performance of targeted temperature management (TTM) at 33 °C using intravascular (IC) vs. surface-cooling (SFC) devices after out-of-hospital cardiac arrest (OHCA). Methods: A post hoc analysis including OHCA patients randomized to hypothermia in the TTM2-trial (NCT02908308) comparing hypothermia with normothermia. The main outcome was cooling performance, defined as the p

We have developed a method for simultaneous tomosynthesis and mechanical imaging, called DBTMI. Mechanical imaging measures the stress distribution over the compressed breast surface. Malignant tissue is usually stiffer than benign, which results in higher stress on the compressed breast and enables to distinguish malignant from benign findings. By combining tomosynthesis and mechanical imaging, w

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Scree

Ur ett hundraårsperspektiv har arbetsmarknaden genomgått avsevärda förändringar. Majoriteten av löntagarna utgörs numera av tjänstemän. I Sverige svarar de även för majoriteten av fackmedlemmarna. De svenska fackföreningarna tillämpade redan tidigt en bred medlemsrekrytering, men till bilden hör också att Sverige har världens mest klassuppdelade fackliga rörelse. Inte minst för tjänstemännen har d

Popular Abstract in Swedish Hur påverkas djurplanktonsamhällen av klimatförändringar och vilken betydelse har vilostadier? Populärvetenskaplig sammanfattning av “Ecology of zooplankton communities: climate, dormancy and benthic-pelagic coupling”, doktorsavhandling i Limnologi vid Ekologiska institutionen, Lunds Universitet, 2003. Djurplankton är sjöars motsvarighet till betande kossor ochThis thesis describes how influences, such as top down and bottom up forces, shape zooplankton communities in shallow lakes. I have also extended the traditional food-web theory by investigating the effects of climate on total biomass, taxonomic composition, and temporal properties of zooplankton communities. A field experiment showed that the total biomass of both phytoplankton and zooplankton in

This paper aims to support the decision-making tasks regarding the integration of packaging development into product development. Based on the study of the interactions of the product and packaging during the whole product life cycle, a set of packaging-related factors was extracted and mapped to a general product development model, which at a strategic level can be used to define an integrated pr

In this project a technique to optically measure the temperature is evaluated. The measurement is to be performed through optical fibres during photodynamic laser treatments or laser thermo therapy of malignant tumours. For this technique Cr³⁺-doped crystals were used. The lifetime of the ions' fluorescence were measured, since the fluorescence is strongly temperature dependent. A piece

We present a novel method for estimating the depth of a fluorescent lesion in tissue based on measurements of the fluorescence signal in different wavelength bands. The measured fluorescence spectrum following irradiation by excitation light at the surface is a function of several parameters, because the fluorescence light has to pass through tissue with characteristic scattering and absorption pr

Historiskt sett har människor gjort invändningar grundade på tankefrihet, samvetsfrihet och religionsfrihet i förhållande till obligatorisk värnpliktstjänstgöring. Denna samvetsvägran inom militären är en erkänd rätt i nationella, regionala och internationella människorättsinstrument. I den Europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna är denna rätHistorically, objections based on the freedom of thought, conscience and religion have been invoked in relation to compulsory military service. These conscientious objections are protected by national, regional and international human rights instruments. In the European Convention on Human Rights this right is grounded in Article 9 on the freedom of thought, conscience and religion. In Europe, the

Populärvetenskaplig sammanfattning: Klimatväxlingarna under sista istiden har alltid varit en debattfråga. Denna istids kallaste period inträffade för cirka 20.000 år sedan och benämns "istidsmaximum". Då var havsytan hundratjugo meter lägre än idag och det mesta vattnet var bundet i inlandsisarna. Klimatväxlingar försöker dagens kvartärgeologer att fastställa med en så bra tidsutlösningHigh-resolution analyses of sediments from two sites in Blekinge, south-eastern Sweden (the former Lake Togölen and Lake Bredsjön), were evaluated in order to establish the pollenstratigraphical position of the second and final drainage of the Baltic Ice Lake in relation to the Younger Dryas-Preboreal pollen zone transition. Remanent magnetisation and magnetic susceptibility were used to correlate

Background and Objectives: This project explored the needs of art galleries and collectors for Digital Asset Management Systems (DAMS), in order to fill an existing knowledge gap and help companies to analyse these needs. Bespoken difficulties in the field significantly challenge the development of DAMS and have thus also hampered the evolvement of high-quality systems for the art market. There se

The central theme of this thesis is anthropogenic climate change; governments' inability to create an effective, inclusive response mechanism that manages to mitigate anthropogenic emissions; and advocates efforts to coerce States to act by invoking State responsibility in adjudicatory dispute settlement processes. States' failure to act in accordance with scientific risk assessments and