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This paper introduces a model of the atrioventricular node function during atrial fibrillation (AF), and describes the related ECG-based estimation method. The proposed model is defined by parameters that characterize the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two atrioventricular nodal pathways, the refractory periods of these pathways, and the p
Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our re
Left atrial (LA) enlargement is a pathophysiological response to volume overload resulting from chronic mitral regurgitation (MR), is known as LA remodeling, and has been shown previously to be associated with cardioembolic events. Following mitral valve surgery (MVS), the left atrium may undergo reverse remodeling characterized by LA volume reduction. The study aim was to evaluate the incidence a
Purpose – The aim is to understand customers' willingness, or unwillingness, to pay a price premium in the market for consumer packaged food and what kind of images brands can use in order to achieve a price premium. Design/methodology/approach – The study is based on a quantitative survey of brand images found in food and branding literature and their impact on loyalty as well as customers' will
We study and solve the previously unstudied problem of finding both transmitter and receiver positions using only time of arrival (TOA) measurements when there is a difference in dimensionality between the affine subspaces spanned by receivers and transmitters. Anchor-free TOA network calibration has uses both in radio, radio strength and sound applications, such as calibrating ad hoc microphone a
Understanding the uncertainty of climate models in space and time is necessary to help water resources managers and hydrologists in the selection of appropriate model for a specific application. In this paper, we use three separate methods to evaluate and compare the utility of 14 climate models for seven basins with area range of 2,656–26,355 km2 on the South Korean Peninsula. On the one hand, th
The aim of this study was to evaluate how the fixed furniture dimensions match with students' anthropometry and to describe head, upper back and upper limbs postures and movements. Evaluation was performed in 48 students from a Brazilian state school. Furniture dimensions were measured with metric tape, movements and postures by inclinometers (Logger Tecknologi, Akarp, Sweden). Seat height was hig
Cervical dystonia is a neurological movement disorder causing abnormal posture of the head. It may be accompanied by involuntary movements which are sometimes tremulous. The condition has marked effects on patients' self-image, and adversely affects quality of life, social relationships and employment. Botulinum neurotoxin (BoNT) is the treatment of choice for CD and its efficacy and safety have b
Heme A is a prosthetic group unique for cytochrome a-type respiratory oxidases in mammals, plants and many microorganisms. The poorly understood integral membrane protein heme A synthase catalyzes the synthesis of heme A from heme O. In bacteria, but not in mitochondria, this enzyme contains one or two pairs of cysteine residues that are present in predicted hydrophilic polypeptide loops on the ex
An activity-based vocabulary for Voice Output Communication Aids (VOCAs) was designed and evaluated through a user-centred, iterative design process, using expressions from the Gothenburg Spoken Language Corpus as well as other recorded, natural conversations. The growth and development of the vocabulary, called Phrases, was closely linked to its evaluation. The iterative design process included p
Service discovery is central in pervasive middleware systems, built on top of the communication substrate using the more fundamental mechanisms for device discovery. In mobile pervasive systems devices come and go, and switch network frequently, demanding support for device discovery across heterogeneous networks. We present the design of a device discovery mechanism for the PalCom middleware that
A pulse of respiration is induced by rewetting dry soil. Here we study the microbial responses underlying this pulse of respiration when rewetting soil dried for 4-days or 1-year. In the 4-days dried soil, respiration increased to a maximum rate immediately upon rewetting after which it decreased exponentially. In the 1-year dried soil, respiration also increased immediately, but then remained hig
The results of a search for an excited bottom-quark b* in pp collisions at root s = 7 TeV, using 4.7 fb(-1) of data collected by the ATLAS detector at the LHC are presented. In the model studied, a single b*-quark is produced through a chromomagnetic interaction and subsequently decays to a W boson and a top quark. The search is performed in the dilepton and lepton + jets final states, which are c
Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) o
We report the development of a high-level bacterial expression system for the Alzheimer's disease-associated amyloid beta-peptide (A beta), together with a scaleable and inexpensive purification procedure. A beta(1-40) and A beta(1-42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-A beta(1-40) and Met-A beta(1-42), referred t
Experimental single-phase, condensation, and evaporation (flow boiling) pressure drop data from the literature and our previous studies were collected to evaluate previous frictional pressure drop correlations for horizontal microfin tubes of different geometries. The modified Ravigururajan and Bergles correlation, by adopting the Churchill model to calculate the smooth-tube friction factor and by
This paper explores a global trend where universities are collaborating with local government, industry and civic organisations to advance the sustainable transformation of a specific town, city or region. With empirical evidence, we argue that this function of ‘cocreation for sustainability’ could be interpreted as the seeds of an emerging, new mission for the university. We demonstrate that this
Industrial fermentation of lignocellulosic hydrolysates to ethanol requires microorganisms able to utilise a broad range of carbon sources and generate ethanol at high yield and productivity. D. bruxellensis has recently been reported to contaminate commercial ethanol processes, where it competes with Saccharomyces cerevisiae [4, 26]. In this work Brettanomyces/Dekkera yeasts were studied to explo
Climate warming is expected to alter hydropower generation in California through affecting the annual stream-flow regimes and reducing snowpack. On the other hand, increased temperatures are expected to increase hydropower demand for cooling in warm periods while decreasing demand for heating in winter, subsequently altering the annual hydropower pricing patterns. The resulting variations in hydro
