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Background: Drug repurposing provides a cost-effective approach to address the need for breast cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR) and then validate the candidate drugs using population-based analyses. Methods: We identified genetic instruments for 1406 actionable targets of approved non-oncological drugs based on

Introduction: Risk evaluation for preeclampsia in early pregnancy allows identification of women at high risk. Prediction models for preeclampsia often include circulating concentrations of placental growth factor (PlGF); however, the models are usually limited to a specific PlGF method of analysis. The aim of this study was to compare three different PlGF methods of analysis in a Swedish cohort t

Background: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort. Methods: Single nucleotide polymorphism array data from 13071 EOC cases and 17306 controls of White European ancestry were used to identify CNVs associated with EOC risk

Obesity levels in developing countries are increasing at an alarming rate, while “old” problems such as hunger and undernutrition still persist, creating a paradoxical situation of a double burden of malnutrition. Intertwined with new sustainability challenges such as climate change and land degradation, food, health and sustainability are interconnected in a complex web of relationships, spanning

Reseavdraget – Motverkar det politiska spelet incitament som kan förbättra miljön? Reseavdraget, att vara berättigad till att dra av en del av kostnaderna som uppkommer till följd av resor till och från arbetsplatsen på skatten, har förundrat mig under flera år. Är reseavdraget rättvist utformat, belönar det ett samhällsekonomiskt olönsamt val eller kan det skapa incitament för arbetspendlare attIncome Tax-deduction for commuting expenses has been criticised and discussed for a long time without having reached any conclusions or reformations. Critical opinions in the debate are that a reformation would disfavour taxpayers living in the countryside with no options except car commuting and decreasing size of labour market regions. At the same time tax evasion is a huge problem because taxpa

This bachelor thesis’ ambition is to unravel the rights discourse in the first female emancipatory journal in Sweden during the journal’s first decade 1859-1869. The Swe-dish female rights movement is during this time period unorganized and hence Tidskrift för hemmet became the first forum where a female emancipatory debate took place. By using a conceptual history analysis with philological eleme

I denna uppsats undersöker jag Scanlons värdeteori, med fokus på hans syn på intrinsikalt värde, och då framför allt frågan huruvida människolivet kan sägas ha intrinsikalt värde. Genom att först grundligt presentera Scanlons värdeteori – hans hänskjutande redogörelse för värde (eng. Buck-Passing) - och sedan släppa fram kritiska röster, resonerar jag mig fram till en grund att stå på i denna värd

Enterprise Resource Planning (ERP) systems have been used by organizations and companies the world throughout since 1990. Many universities have recently replaced their legacy systems with ERP systems to improve work efficiency. One solution available for universities by way of management information system is the Campus ERP system. The Campus ERP system helps universities incorporate all departme

Studiens avsikt är att undersöka den information man kan få fram med hjälp av undersökningsinstrumenten, Adult Attachment Interview och Inventory of Interpersonal Problems och syftar till att belysa dessas användbarhet i en klinisk kontext. Studien bygger på både kvalitativ och kvantitativ metod, vilket innebär, semistrukturerade intervjuformulär, fallbeskrivning samt självskattningsformulär. Stud

Sustainable development requires a change of values, norms, and capabilities within individuals and societies, and education is a crucial means to achieve these goals. However, transformation is not a simple task as dominant structures due to path-dependency and lock-in processes resist change, put pressure on innovative approaches, and hinder their potential for change. Thus the question is how s

So, what does a new life for the old fire station mean? It means that it is possible for a new generation to utilize the Gåsebäck landmark and historical building. The building should be attractive for the investors, for the city, and its inhabitants. The provided opportunities for the development of the building could be considered as a temporary solution for maintaining the history of the Gåsebä

Three-part parenting is an approach that social services in Sweden should use in collaboration around a child placed in foster care. It describes how foster home, parents and social services share responsibilities for the welfare of the child. The purpose of this study was to illuminate the state of knowledge about the approach among social workers working with children and adolescents in Sweden.

The aim of this study is to investigate how staff who work with persons with mental impairment living in supportive housing describe and reflect on the clients´ self-determination and which options and challenges they experience with respect to putting the intent of the Swedish act concerning support and service for people with certain functional impairments (LSS) regarding self-determination into

Titel: Hur verkligt är verkligt värde? En studie om underprissättning vid börsintroduktioner Seminariedatum: 2 juni 2023 Kurs: FEKH69 – Examensarbete i redovisning på kandidatnivå Författare: Oskar Brunnéd, Simon Sandström, Jamal Shamma Handledare: Liesel Klemcke Syfte: Studien syftar till att undersöka ifall underprissättningen vid börsintroduktioner på Stockholmsbörsen och Nordic Growth Ma

The purpose of this thesis is to evaluate the compatibility of the current dominant approach in international taxation for intragroup transactions, based on arm’s length principle, with international agreements on development. In this sense, the thesis aims to explore the viability of formulary apportionment as an alternative that could reduce contradictions between international tax law and devel

Video Sharing Websites constitute a rather peculiar situation. On one hand, they are considered as part of what the Commission perceives as online sharing economy: users are eligible to derive income from monetizing their audiovisual content. On the other hand, their business model is reminiscent of what is described as “free -economy”: access to the audiovisual content is prima facie provided wit

Gaming as a Service is not defined in existing research. The lack of a formal definition leads to an ambiguity between its function as a business model and the long-term strategy of the firm. The purpose and aim of this study is to investigate the definition of GaaS business model, distinguishing its function from the strategy. Furthermore, the key components of the model are established based on

Recent years has seen a growth of so-called ”Al-Qaeda franchises”, terrorist groups who formally ally with Al-Qaeda. This study investigates the phenomenon through how one such actor, the “Salafist Group for Preaching and Combat” (GSPC), has developed after its alliance with Al-Qaeda in 2006 and rebranding as ”Al-Qaeda in the Islamic Maghreb” (AQIM). By analyzing GSPC before and after the alliance