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Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre
Modulbaserad lakvattenbehandling - en möjlighet att minska soptipparnas påverkan på människa och miljö? Uppemot 8000 gamla övergivna deponier och ett 70-tal aktiva deponier finns i Sverige. Gemensamt för dessa är att de kan ge upphov till ett förorenat lakvatten. Genom tillämpningen av ett modulbaserat reningssystem kan effekterna på människa och miljö begränsas. Modulsystemet har visat sig vara fA change in legislation has resulted in that many of Sweden’s municipal landfills were closed in the beginning of this century. After landfill completion, the oper-ator is responsible for at least 30 years to take action with regard to the protec-tion of human health and the Environment. In contribution Swedish landfill owners are facing increasing demands on local leachate treatment due to a chan
Abstract In today's western society the self-help culture is widespread. It consist of varies of medias: from courses and tv-programs, to articles in papers and magazines and entire books. The aim of many of the self-help books is to help heterosexual couples with problems in their love-life. These books have a large number of readers and are sold in millions of copies around the entire weste
Småvatten är trots sin ringa storlek ekologiskt betydelsefulla och fungerar som habitat för många arter. För groddjur spelar de en avgörande roll för fortplantningen eftersom småvatten används som lekmiljö. Populationer av groddjur minskar idag över hela världen och två av de största hoten mot groddjur är habitatförlust och habitatfragmentering. I Sverige har många småvatten försvunnit som en effeDespite their size, small ponds are ecologically important and act as a habitat for many species. For amphibians they play a significant role for reproduction given that ponds are used as breeding sites. At present amphibian populations are decreasing worldwide and two of the biggest threats they face are habitat destruction and habitat fragmentation. In Sweden many small ponds have disappeared ov
I samband med Covid-19-pandemins inträffande tvingades såväl allmänna domstolar som skiljenämnder världen över att ta ställning till om förhandlingar skulle ställas in i väntan på att smittspridningen skulle gå ner eller om de skulle genomföras med hjälp av tekniska hjälpmedel. Många var snabba med att utnyttja de tekniska möjligheter som stod till buds och det blev på kort tid vanligt med virtuelWith the onset of the Covid-19 pandemic, national courts and arbitration tribunals around the world were forced to decide whether to cancel hearings while waiting for the spread of the disease to subside, or whether to conduct them using technical means. Many were quick to take advantage of the technological means available, and virtual hearings in which all participants are present via some form
Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blunting of diabetes-induced oxidative stress in the islets. Materials and Methods: T2D was created in male rats using a combination of streptozotocin at
Sweden faces an upcoming period where thousands of buildings built during the million program period will be in need of a façade renovation. There is a large energy-saving potential in these buildings, since they are often poorly insulated and often have a ventilation system without heat recovery. Performing energy-efficient renovation measures to a building are expensive, which results in that th
The use of baseline lung function in the prediction of chronic obstructive pulmonary disease (COPD) hospitalisations, all-cause mortality and lung function decline was assessed in the population-based "Men Born in 1914" cohort.Spirometry was assessed at age 55 years in 689 subjects, of whom 392 had spirometry reassessed at age 68 years. The cohort was divided into three groups using fixed ratio (F
Sverige och Danmark anses i komparativa sammanhang tillhöra samma rättsfamilj. I arbetsrättsligt avseende skiljer sig Danmark från övriga nordiska länder på så sätt att man undvikit lagstiftning i mesta möjliga mån och t.o.m. överlåtit implementering av vissa EU-direktiv åt arbetsmarknadens parter genom kollektivavtal. Den lagstiftning som finns är spretig och i stor utsträckning införd p.g.a. EU-In a comparative context Sweden and Denmark are often considered part of the same families of law. In respect of labour law, Denmark differs from the other Nordic countries by avoiding legislation as much as possible and have even left implementation of some EU directives to be performed through collective agreements. The legislation is uneven and to a great extent introduced after demands from th
Den internationella syndikerade lånemarknaden har sina rötter från 1960-talet och har alltsedan dess varit en av de största, mest flexibla och viktigaste finansieringskällorna för stater och företag världen över. Från 1990-talet fram till och med finanskrisens utbrott hösten 2008 växte marknadsvolymerna kraftigt. Sedan dess har volymerna minskat dramatiskt. Kärnan i ett syndikerat lån är att tvåThe international syndicated loan market has its roots from the 1960s and has ever since been one of the largest, most flexible and most important sources of funding for states and corporations worldwide. From the 1990s until the financial crisis started in the autumn of 2008 market volumes grew sharply. Since then, however, volumes have dropped dramatically. The core of a syndicated loan is that
Tidningen Gourmet har varit föremål för en medial blickfokus under våren 2003. Konsumentombudsmannen väckte talan mot tidningsföretaget Gourmet International Products Aktiebolag (GIP) för att ha givit ut otillåten kommersiell alkoholreklam riktad till konsumenter. Konsumentombudsmannen grundade sin talan mot GIP på det svenska alkoholreklamförbudet. Alkoholreklam har under slutet av 1900-talet omf
Qualitative measurements of both OH and polycyclic aromatic hydrocarbons (PAH) as well as quantitative data of soot volume fraction f(v) have been obtained in vaporized liquid fuels, with the main goal of providing experimental data for combustion models and numerical mechanism validation. Measurements were carried out in a laminar coflow burner which was designed, built and integrated with an eva
The aim of this multicenter study was to investigate whether a computer-assisted diagnosis (CAD) system could improve performance and reduce interobserver variation in bone-scan interpretations of the presence or absence of bone metastases. Methods: The whole-body bone scans (anterior and posterior views) of 59 patients with breast or prostate cancer who had undergone scintigraphy for suspected bo
Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase ca
The Universal Thermal Climate Index (UTCI) aimed for a one-dimensional quantity adequately reflecting the human physiological reaction to the multi-dimensionally defined actual outdoor thermal environment. The human reaction was simulated by the UTCI-Fiala multi-node model of human thermoregulation, which was integrated with an adaptive clothing model. Following the concept of an equivalent temper
Background: Food consumption is one of the most important drivers of environmental pressures. Adoption of healthy diets is suggested to be an option for less environmentally intensive food habits and improved public health. In particular, changes in meat consumption are believed to bring potential benefits. Objective: To quantify the impact of changes in meat consumption on the dietary contributio
Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acu
The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and dir
G protein-coupled estrogen receptor (GPER), or GPR30, is a membrane receptor reported to mediate non-genomic estrogen responses. Tamoxifen is a partial agonist at GPER in vitro. Here, we investigated if GPER expression is prognostic in primary breast cancer, if the receptor is treatment-predictive for adjuvant tamoxifen, and if receptor subcellular localization has any impact on the prognostic val
The aim of this study was to assess the reproducibility of isokinetic and isometric ankle dorsiflexor strength measurements in individuals with post-polio syndrome (PPS). Thirty-one men and women (mean age 63 +/- 7.0 years) with verified PPS, participated in an intra-rater test-retest reproducibility study. Strength of the ankle dorsiflexor muscles in both lower limbs were measured twice, seven da
