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Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.
Distance mapping of protein-binding sites using spin-labeled oligosaccharide ligands
Proton transfer at metal sites in proteins studied by quantum mechanical free-energy perturbations
Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease – a Swedish Gynecologic Cancer Group (SweGCG) study
Background: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. Method: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between
A European aerosol phenomenology-5 : Climatology of black carbon optical properties at 9 regional background sites across Europe
A reliable assessment of the optical properties of atmospheric black carbon is of crucial importance for an accurate estimation of radiative forcing. In this study we investigated the spatio-temporal variability of the mass absorption cross-section (MAC) of atmospheric black carbon, defined as light absorption coefficient (σap) divided by elemental carbon mass concentration (mEC). σap and mEC have
Detection by near-infrared spectroscopy of large lipid cores at culprit sites in patients with non-st-segment elevation myocardial infarction and unstable angina
ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are character
Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site
Site Specificity and Street Art
Structure of the molybdenum site in YedY, a sulfite oxidase homologue from escherichia coli
Using Multi-objective Genetic Algorithm for Site Selection of Industrial Factories
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Healthcare utilization for somatic conditions among Swedish patients in opioid substitution treatment, with and without on-site primary healthcare
Background: Opioid substitution treatment (OST) populations are aging and have increased mortality and somatic morbidity compared to general populations internationally. While OST patients have poor self-rated physical health and unmet healthcare needs, documented healthcare utilization has been sparsely investigated. The aim of this study was to assess registered healthcare utilization for somati
BVOC ecosystem flux measurements at a high latitude wetland site
Comparison of soldier fly (Diptera: Stratiomyidae) and thick-headed fly (Diptera: Conopidae) diversity at two trapping sites
Jämförelse av två flugfamiljers mångfald i två olika naturtyper Djurs mångfald är inte bara intressant utan även viktigt för att vår värld ska fungera i harmoni och kretsloppen ska slutas och gå runt. Vissa djur behövs för att bryta ned vissna växter och andra för att hålla insekters antal i schack. Några djur kan även vara tecken på om naturen mår bra eller dåligt. Olika naturtyper är hem för olBiodiversity is a big part of the understanding of our life and its surroundings. Only a fraction of the earth’s species are known and many are yet to be found. When describing new species often both molecular and morphological data is needed to fully resolve cryptic taxa. In this study, the diversity of two Diptera families, soldier flies (Stratiomyidae) and thick-headed flies (Conopidae), have b
Management of saltpans as potential foraging sites for shorebirds
Abstract Estuaries and salt marshes are important wetlands used by waterbirds during winter and migration. However, many salt-marshes have been transformed into salinas, which currently function as high-tide roosts. Since traditional salt production is no longer profitable, many salinas have been abandoned or converted into aquaculture potentially becoming less attractive to waders. In this study
Catalysis by RNase P RNA. Unique Features and Unprecedented Active Site Plasticity.
Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS 1)
The Arabidopsis MAP kinase 4 (MPK4) substrate MKS1 was expressed in Escherichia coli and purified, full-length, 6x histidine (His)-tagged MKS1 was phosphorylated in vitro by hemagglutinin (HA)-tagged MPK4 immuno-precipitated from plants. MKS1 phosphorylation was initially verified by electrophoresis and gel-staining with ProQ Diamond and the protein was digested by either trypsin or chymotrypsin f
Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution
Apolipoprotein A-I (apoA-I) is the major protein constituent of high density lipoprotein (HDL) and plays a central role in phospholipid and cholesterol metabolism. This 243-residue long protein is remarkably flexible and assumes numerous lipid-dependent conformations. Consequently, definitive structural determination of lipid-free apoA-I in solution has been difficult. Using electron paramagnetic
