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Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Geological characterisation of geophysical lineaments as part of the expanded site descriptive model around the planned repository site for high-level nuclear waste, Forsmark, Sweden

Svenska Kärnbränslehanteringen (SKB) startade ett projekt under 2020 i närheten av Forsmark i Sverige med målet att utöka deformationszonsmodellen till att inkludera hela dräneringsområdet runt om det planerade slutförvaret för använt kärnbränsle. Detta arbete bygger på en lineamentmodell som var skapad för SKB. Denna modell använder sig av magnetiska data tillsammans med höjddata samt data insamlThe Swedish Nuclear Fuel and Waste Management Co. (SKB) started a project in 2020 near Forsmark, Sweden with the aim to expand the deformation zone model to encompass the entire catchment area around the planned repository for spent nuclear fuel. This thesis builds upon a lineament model that was constructed for SKB which utilizes airborne magnetic data supported by airborne Very Low Frequency (VL

Studies of protein A and herpes simplex virus-1 induced Fc gamma-binding specificities. Different binding patterns for IgG3 from Caucasian and Oriental subjects

Herpes simplex virus type 1 (HSV-1) expresses a receptor that binds the Fc portion of IgG. This HSV-1 Fc gamma-binding protein is, like protein A of Staphylococcus aureus, known to bind human IgG1, IgG2 and IgG4 but not IgG3 subclasses. However, IgG3 with the allotype Gm(s+)(t+), prominent in the Oriental population, reacts with protein A. This prompted us to investigate the reactivity of Oriental

Molecular characterization and expression of FSHbeta, LHbeta, and common alpha-subunit in male Atlantic halibut (Hippoglossus hippoglossus)

To elucidate the role of the gonadotropins in the multiple spawner Atlantic halibut (Hippoglossus hippoglossus) full length cDNAs encoding FSHbeta, LHbeta, and the common alpha-subunit were cloned from pituitary glands by RACE-PCR. The three cDNAs consisted of 614, 595, and 666 nucleotides encoding peptides of 131, 146, and 124 amino acids, respectively. Halibut FSHbeta and LHbeta showed unique st

French summer droughts since 1326 CE : A reconstruction based on tree ring cellulose δ18O

The reconstruction of droughts is essential for the understanding of past drought dynamics and can help evaluate future drought scenarios in a changing climate. This article presents a reconstruction of summer droughts in France based on annually resolved, absolutely dated chronologies of oxygen isotope ratios (δ18O) in tree ring cellulose from Quercus spp. Samples were taken from living trees and

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Á Linköping, en suede, une petit fille qui`s appelle Maja, demande sa mère que allent on une voyage. Majas mère voire en sa fille and dit heureux: " Maja, quelle bone idea, nous allons deamin!" Ils prendons ses valise and allons de la voiture, mais ils avont trop beaucoupe valises. Un jour après, ils sont en italie à un cinq etolis hotel. " Ahh... Quelle bon hotel. Je esperè le temp voir bien." Ma

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_longitudinal/billy/Texte_3.txt - 2026-05-21

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Á Linköping, en suede, une petit fille qui`s appelle Maja, demande sa mère que allent on une voyage. Majas mère voire en sa fille and dit heureux: " Maja, quelle bone idea, nous allons deamin!" Ils prendons ses valise and allons de la voiture, mais ils avont trop beaucoupe valises. Un jour après, ils sont en italie à un cinq etolis hotel. " Ahh... Quelle bon hotel. Je esperè le temp voir bien." Ma

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_b/Billy.txt - 2026-05-23

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Une famille d'Italie vont aller en Italie. La famille est est une mère et sa fille. La mère est tres grosse et la fille est mince et plus grande de la mère. Mais quand elles vont aller, l'automobile a trop beaucoup du bagage. Maintenant, tout est bien, et le jour de voyage et le jour de l'été. Qaund la mère et ca fille arrivent dans l'hôtel, l'homme comme travaille là est ne sympatique pas. Mais,

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_b/Beata.txt - 2026-05-23

TIDPLAN-20251113

Blad1 Senast datum Kl Datum t o m System Period Check Checklista inst/fak Information central hantering Länk 11/11/25 Raindance 10 ⃝ Registrera/komplettera intrastatuppgifter. Åtgärda alla poster som har status Ej komplett. Guide 11/25/25 Raindance 11 Bokföringsdag för Statsbudgetanslag – kommer med i saldolistor tidigare 11/25/25 Raindance 11 Bokföringsdag för Primulatransaktioner, kommer med i s

https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2025-11/TIDPLAN-20251113.xlsx - 2026-05-25

On-Conditionalism : On the verge of a new metaethical theory

This paper explores a novel metaethical theory according to which value judgments express conditional beliefs held by those who make them. Each value judgment expresses the belief that something is the case on condition that something else is the case. The paper aims to reach a better understanding of this view and to highlight some of the challenges that lie ahead. The most pressing of these revo

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Cette histoire, il s'agit de deux filles Suèdoises qui veulent partir en Italie. Maria, une fille grosse avec beaucoup de cheveux blanches, rêve des plages jaunes, des vagues bleues et beaucoup de soleil. Åsa, au contraire, elle pense à les garcons italiens et de la grande amour! Åsa a une robe bleu et elle est brunette. Elles parlent de ses idées et boivent le café, et tous les deux sont très heu

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_d/Darleen.txt - 2026-05-23

Expedition 391 summary

Hotspot tracks (chains of seamounts, ridges, and other volcanic structures) provide important records of plate motions, as well as mantle geodynamics, magma flux, and mantle source compositions. The Tristan-Gough-Walvis Ridge (TGW) hotspot track, extending from the active volcanic islands of Tristan da Cunha and Gough through a province of guyots and then along Walvis Ridge to the Etendeka flood b

Self-reported versus professionally assessed functional limitations in community-dwelling very old individuals.

The objective of this study was to examine the relationship between self-reported and professionally assessed functional limitations in community-dwelling very old individuals. In total, 306 single-living adults aged 81-90 years were included in this cross-sectional study. The main outcome measure was the presence and absence of self-reported and professionally assessed functional limitations. A s

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Marie et Carla vont faire un voyage en Italie. Marie est grosse et blonde avec une robe verte, Carla est mince et brune. Les filles ont trop de sac. Mais maintenant elles vont en Italie. Le garcon dans l'hotel est strict et il a un grand (?). Les filles a une bonne chambre a bord de la mer. Le soleile brille. Les filles vont sur la plage. Marie a une bikini verte et Carla une blanche. Elles ont de

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_transversal/stade_c/Carin.txt - 2026-05-23