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Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. Dendritic cells (DCs) ar

Popular Abstract in Swedish Vad har den slaviskt inspirerade östersjökeramiken som arkeologer finner i Skandinavien med slaver att göra? Levde de som gäster i huset? Vikingen och hanseaten har sedan länge sina platser inbokade på den historiska scenen. Under äldre medeltid rörde sig även andra aktörer över Östersjöns vatten. Främmande gäster besökte och bosatte sig i Skandinavien. Bland dem fanns Scholarly texts on Slavic-Scandinavian relations have concentrated on two main areas of interest. During the Viking Age the economic and social contacts between the lake Mälaren district and Rus’ were extensive. However, at the beginning of the Middle Ages, political antagonism between the two expanding realms of the Svear and the Novgorodians is noticeable. In southern Scandinavia, the hostility

Popular Abstract in Swedish Denna avhandling handlar om stam- och progenitorceller från den embryonala mushjärnan. Jag har studerat dessa cellers förmåga att växa in vitro (utanför kroppen) samt efter transplantation till hjärnan hos vuxna och nyfödda råttor. Forskning om stamceller har länge varit ett populärt och uppmärksammat forskningsområde, men under de senaste åren har intresset i det närmaIn this thesis we have used cells dissected from the lateral ganglionic eminence (LGE), the medial ganglionic eminence (MGE), and the cortical primordium of the embryonic mouse forebrain. The tissue was dissected from either i) wild-type mice, ii) green fluorescent protein (GFP)-, or iii) Gtv-a-expressing transgenic mice, and subsequently grown and expanded in vitro using two different protocols.

Popular Abstract in Swedish Akut leversvikt medför hög risk för komplikationer orsakade av bakteriesepsis. Hög nivåer av lipopolysackarider (LPS; endotoxin) i det portala blodet kan leda till förhöjd sekretion av pro-inflammatoriska signalsubstanser från leverns Kupffer-celler, vilket har visats vara ett tidigt och viktigt tecken på leverskada. Patogenesen för inflammatorisk tarmsjukdom (?inflammaAcute liver failure is accompanied by a high rate of bacterial septic complications. High portal level of lipopolysaccharide (LPS) can lead to a pronounced secretion by Kupffer cells of pro-inflammatory mediators which have been shown to be early and important mediators of liver injury. Pathogenesis of inflammatory bowel disease (IBD) is complex; involving environmental, genetic, microbial, and im

The role of Apolipoprotein A-I (ApoA-I), the main protein component of HDL, in cholesterol transport and metabolism is well known and has been studied for more than four decades. More recently, ApoA-I protein has been shown to also have a positive role in glucose control by both stimulation of glucose uptake by muscles and by increasing glucose-stimulated pancreatic insulin secretion. Two of the f

Popular Abstract in Swedish I mitt doktorandprojekt har jag studerat den fästingspridda bakterien Borrelia och dess värddjur skogssork. Det övergripande syftet har varit att kartlägga den genetiska variationen i den delen av immunförsvaret som tar hand om bakterieinfektioner, som till exempel borrelia. I alla ryggradsdjur finns ett specifikt immunförsvar som kan identifiera små proteinbitar från eThe major histocompatibility complex (MHC) class IIB genes exhibit extensive allelic polymorphism, most likely maintained by pathogen-mediated balancing selection (PMBS). PMBS may operate in the form of heterozygote advantage (HA), and/or through the interaction of pathogens and specific MHC alleles via fluctuating selection (FS) or negative frequency-dependent selection (NFDS). In particular, NFD

Introduction: Vertebral fracture is a strong risk factor for future spine and hip fractures; yet recent data suggest that only 5-20% of subjects with a spine fracture are identified in primary care. We aimed to develop easily applicable algorithms predicting a high risk of future spine fracture in men and women over 50 years of age. Methods: Data was analysed from 5,561 men and women aged 50+ year

There is increasing evidence that fermentation in the large intestine is important for health, and that health-promoting effects are mediated by fermentation products such as butyric and propionic acid. As the formation of carboxylic acids (CAs) from various carbohydrates reaching the colon has been shown to vary, it is of great interest to identify food factors that could be of importance to this

The thesis concerns modeling, simulation and numerical analysis of heat and mass transport, and fluid flow in ducts of both solid oxide fuel cells (SOFCs) and proton exchange membrane fuel cells (PEMFCs). The unique fuel cell boundary conditions (thermal, mass) for the flow ducts in fuel cells are identified and applied. Various duct configurations have been studied, such as rectangular and trapez

Tidigare forskning om motivation vid lärande har tenderat att fokusera på attributioner (de tolkningar elever och andra gör av orsaker till framgångar och misslyckanden) självuppfattning, målorientering och elevers autonomi. Denna avhandling syftar dels till att beskriva bakgrunden och skolgången för de elever som går på gymnasiets estetiska programs musikgren, dels till att mäta den motivation deIn previous studies research on motivation in education has tended to be focused on attribution (perceived causes of success and failure), self perception, goal orientation and autonomy. This thesis aims to describe the background and schooling of music students and to measure their motivation for music education. Motivation is viewed as a cognitive process, which influences learning through achie

Popular Abstract in Swedish Parkinsons sjukdom beror på att de dopamin-producerande cellerna i hjärnan dör. Detta leder till minskad rörlighet, svårigheter i att påbörja och avsluta en rörelse, balanssvårigheter och darrningar (tremor) hos de drabbade patienterna. Varför dopamincellerna dör är oklart och i nulägat kan man inte bota Parkinsons sjukdom, men man kan lindra symptomen med mediciner. PaParkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. This works very well during the initial treatment period, but unfortunately a majority of the patients develop abnormal involu

In the production of pulp and paper, water-soluble components, such as hemicellulose, monosaccharides, and lignin, are released and accumulate in the process water. The process water is usually concentrated and incinerated for heat generation and the recovery of pulping chemicals, such as in the Kraft and sulfite processes. The growing trend toward a more sustainable forest industry has increased

Plant nutrients can be recycled through microbial decomposition of organic matter but replacement of base cations and phosphorus, lost through harvesting of biomass/biofuels or leaching, requires de novo supply of fresh nutrients released through weathering of soil parent material (minerals and rocks). Weathering involves physical and chemical processes that are modified by biological activity of

Geotechnical engineering is the science dealing with mechanics of soils and rocks and its engineering applications. Geotechnical engineering projects vary in a wide range, from evaluation of the stability of natural slopes and man-made soil deposits, to the design of earthworks and foundations. Traditional methods, using manual calculations or simplified computational methods, do not, as a rule, t

Hand amputation results in the loss of motor and sensory functions, impacting activities of daily life and quality of life. Commercially available prosthetic hands restore the motor function but lack sensory feedback, which is crucial to receive information about the prosthesis state in real-time when interacting with the external environment. As a supplement to the missing sensory feedback, the a

Using Small-Angle Neutron Scattering (SANS) we have studied the flux line lattices of the first heavy-fermion superconductor to be discovered, CeCu2Si2, the well-known high-temperature superconductor YBa2Cu3O7, along with Ca-doped variants of this compound, and several topological superconductor candidates that have attracted a lot of attention in the last few years, such as PbTaSe2, Au2Pb and β-B

Hjärtstopp inträffar när hjärtat plötsligt slutar slå och är ett livshotande tillstånd. Av personer som drabbas av hjärtstopp utanför sjukhus överlever endast en av tio fram till utskrivning från sjukhuset. Hjärnan har en hög ämnesomsättning och små energidepåer. Därför är hjärnan extra känslig för effekterna av ett hjärtstopp. När hjärtat slutar slå och blodet inte kan cirkulera i kroppen riskeraBackground: The brain is susceptible to hypoxic-ischemic brain injury in conjuction with out-of-hospital cardiac arrest (OHCA). Cognitive impairments are documented in about half of all OHCA survivors, however with a pronounced heterogeneity in measurements and findings. More detailed studies and instruments that are sensitive to OHCA-related cognitive impairment, including predictive models to id

Land-use change is one of the greatest threats to biodiversity. Through intensification of land-use, the agricultural landscape has become more homogenous and a result, many species associated with traditional farmland or other semi-natural open habitats have declined. To be able to improve biodiversity conservation we need to be able to track components of biodiversity and understand how they res

Primary debulking surgery (PDS) followed by platinum-based postoperative chemotherapy isthe standard of care for advanced ovarian cancer (AOC). Absence of macroscopic residualdisease after debulking surgery is the strongest prognostic factor achieved by surgery. Correctcharacterization of the tumor specimen and tumor spread in combination with patient’scharacteristics such as age, comorbidity, and

When doped into solid state transparent crystals, rare-earth ions can have optically excited states with milliseconds coherence time and up to six hours coherence time for hyperfine levels after being cooled down to liquid helium temperature. This long coherence property makes them unique as solid state material and attractive for quantum information applications.The rare-earth ions have narrow ho