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Tracing marine hypoxic conditions during warm periods using a microanalytical approach

Deoxygenation, i.e. loss of oxygen from the oceans, often considerably influences the aquatic organisms and the wholeecosystem and changes biogeochemical cycles. It results in increasing bottom areas of hypoxia (<2 mg/l dissolved oxygen),which has been primarily attributed to global warming and increased eutrophication. It is vital to study the present-dayanthropogenically-induced environmental ch

Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2‐positive patients with insulin‐dependent diabetes mellitus

Abstract: HLA‐DR2 is negatively associated with insulin‐dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2‐positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA‐DRB, ‐DQA and ‐DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction

The heat is on : Evaluation of workplace heat stress under a changing climate

Background: There are several scientific indications that increasing heat due to climate change is going to become the next big societal and scientific challenge. Climate change is recognized as a significant public health threat. However, there is a lack of research on its impacts on occupational safety and health. Aims and Objectives: The general aim of the research presented in this thesis was

Rural Gentrification in Desakota : Farmland Politics, Alternative Food Networks, and the Emergence of New Farmers in Taiwan

Efter en landreform, som genomfördes i slutet av 40- och i början av 50-talet, blev de flesta taiwanesiska bönderna hemmansägare och odlade marken på små lantegendomar. Denna efterkrigsreform banade väg för en ekonomisk utveckling som väsentligt påverkade och förändrade bondesamhället. När det taiwanesiska jordbruket visade tecken på stagnation på 1970-talet, förändrades böndernas syn på markinnehAfter post-war land reform that took place between 1949 and 1953, most Taiwanese farmers became owner-cultivators working on small landholdings. Post-war land reform paved the foundation for economic development and industrialization, processes that squeezed the agricultural sector and created changes in farming villages. When Taiwanese agriculture showed signs of stagnation in the 1970s, farmers’

Epidemiology of osteoarthritis in Sweden. Register and cohort studies on prevalence and mortality.

Osteoarthritis (OA) is the most common form of arthritis and often causes pain and functional impairment. Despite its high burden on society, knowledge about the occurrence of OA and its associated mortality is sparse. The epidemiology of OA is difficult to determine due to the patients’ fluctuating symptoms and challenges in detecting and defining the radiographic disease. The specific aims of th

Modelling the role of agriculture for the 20th century global terrestrial carbon balance

In order to better assess the role of agriculture within the global climate-vegetation system, we present a model of the managed planetary land surface, Lund-Potsdam-Jena managed Land (LPJmL), which simulates biophysical and biogeochemical processes as well as productivity and yield of the most important crops worldwide, using a concept of crop functional types (CFTs). Based on the LPJ-Dynamic Glo

Adjuvant chemotherapy for endometrial cancer after hysterectomy

Background Endometrial adenocarcinoma (womb cancer) is a malignant growth of the lining (endometrium) of the womb (uterus). It is distinct from sarcomas (tumours of the uterine muscle). Survival depends the risk of microscopic metastases after surgery. Adjuvant (postoperative) chemotherapy improves survival from some other adenocarcinomas, and there is evidence that endometrial cancer is sensitive

Mechanisms of microbial-host interaction during asymptomatic bacteriuria

Popular Abstract in Swedish Mer än hälften av alla kvinnor har haft en urinvägsinfektion. Infektionen uppkommer när bakterier når urinblåsan och börjar växa. Immunförsvaret känner igen bakterierna, reagerar med en inflammation och symptom som sveda, trängningar och smärtor i nedre magtrakten uppstår. Om bakterierna klättrar upp till njurarna sprider sig inflammationen dit och orsakar ryggsmärtor o

Cognitive function after cardiac arest and targeted temperature management

This thesis focuses on cognitive impairment in Out-of-Hospital Cardiac Arrest (OHCA) survivors with the main aim to evaluate possible effects by targeted temperature management. Secondary aims are to describe the prevalence of cognitive impairment in a large group of OHCA-survivors, the related symptoms of psychological distress and the actual effect of cognitive impairment for the patient’s abili

Electroencephalography for neurological prognostication after cardiac arrest

Popular Abstract in Swedish Hjärt-kärlsjukdom är en av västvärldens stora folksjukdomar. I Sverige drabbas årligen cirka 10 000 personer av plötsligt hjärtstopp. Den vanligaste orsaken är att en akut hjärtinfarkt orsakar ett ”elektriskt kaos” i hjärtat. Vid ett hjärtstopp upphör blodförsörjningen till hjärnan, vilket leder till medvetslöshet inom några sekunder och inom några få minuter börjar hjäThis thesis focuses on the prognostic value of electroencephalography(EEG) in comatose patients resuscitated after cardiac arrest (CA), using both simplified continuous EEG monitoring (cEEG) and routine EEG. Background: Comatose survivors are admitted to an intensive care unit (ICU) to support vital functions. Postresuscitation care includes target temperature management (TTM) for 24 hours. The d

Aspects of skin cancer diagnosis in clinical practice

Popular Abstract in Swedish Förekomsten av hudcancer ökar i ljushyade befolkningsgrupper och hudcancer tillhör de cancergrupper som ökar mest i Sverige. De tre vanligaste formerna av hudcancer är basalcellscancer, skivepitelcancer och malignt melanom. Under 2013 utgjorde skivepitelcancer och malignt melanom ca 16 % av alla cancerfall som rapporterades in till Svenska Cancerregistret; över 6 000 faSkin cancer incidence is increasing in fair-skinned populations. The three most common skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). A correct diagnosis is crucial for an efficient and tailored treatment for the skin cancer patient. The purpose of this thesis was to evaluate different aspects of the preoperative diagnosis of skin cancer. Th

Spectroscopic characterization of the coordination chemistry and hydrolysis of gallium(III) in the presence of aquatic organic matter

Interactions between metals and natural organic matter (NOM) are of great environmental importance and one of the key factors influencing hydrolysis, solubility, and speciation of the metals. However, studying geochemically relevant metals like Al, Fe, and Cu is sometimes associated with analytical problems; for example Fe and Cu are both redox active. Gallium (Ga) is a non-redox active metal that

On problems, joint problem solving and change - A human behavioural approach in a construction sector context.

Critics maintain that there are a number of troublesome issues resulting from the construction sector’s way of operating and that these remain, despite widespread criticism and measures designed to change all of this. The construction sector’s and the critics’ manner of describing these problems fails to a large extent to take into consideration the way people function in connection with practical

Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease

Popular Abstract in Swedish Hemofili A är en form av blödarsjuka som beror på en medfödd defekt av äggviteämnet faktor VIII (FVIII). FVIII spelar en viktig roll för att kroppens blodlevringsförmåga (s.k. koagulation) ska fungera optimalt och med nedsatt funktion hos FVIII riskerar man att drabbas av allvarliga blödningar i framför allt leder, men även i muskler, slemhinnor (t.ex. näsblödning) och

Land-atmosphere interaction of a subarctic palsa mire

The main objective of this thesis was to quantitatively estimate the gaseous exchange of carbon dioxide (CO2) and methane (CH4) between a subarctic wetland ecosystem and the atmosphere. Additionally some initial estimates of the carbon input to the atmosphere of nonmethane hydrocarbons (NMHCs) were also obtained by combining different techniques in a joint setting. The data presented were collecte

Organized self-help housing as an enabling shelter & development strategy. Lessons from current practice, institutional approaches and projects in developing countries

The aim of this study is to develop better understanding on organized self-help housing as an enabling shelter and development strategy to overcome poverty and build more resilient communities. The study addresses organized self-help housing from three different perspectives: a) current practice in developing countries; b) institutional approaches; and, c) the organized self-help housing process.

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the

Safety, tolerability, and antibody response of active A beta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,