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Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance
Can a web-site constitute an establishment for the purposes of jurisdiction and applicable law?
Towards a full greenhouse gas budget at a clear-cut and stump harvested boreal forest site in Sweden
Site investigation with combined methods in a faulted area in Managua, Nicaragua - a pre-study
Geophysical methods are increasingly being applied to geotechnical investigations, as they can identify material properties and material boundaries, as well as variations in space and time of relatively large volumes of soil. Another advantage is that many of these methods are non-intrusive. The combination of several methods and the verification of their results by sampling and correlating with g
Learning across Sites through Learning by Design in Use
Site Visit - The implementation of the Bologna Process in Malta and with focus on regional development
Sacred Sites : Burial Customs in South Scandinavian Bronze and Iron Age
Media and Participation: A Site of Ideological-Democratic Struggle
A new terrestrial Cretaceous-Paleogene site in New Zealand-turnover in macroflora confirmed by palynology
A fluvial sequence near Cave Stream (north of Castle Hill Village, central Canterbury), New Zealand, contains organically-preserved plant macrofossils (cuticles). The almost ubiquitous presence of Araucariaceae macrofossils in the lower part of the section and their stratigraphic disappearance roughly coincident with the appearance of the angiosperm leaf Dryandra comptoniaefolia and conifer taxa o
Characterization of New Particle Formation Events at a Background Site in Southern Sweden: Relation to Air Mass History
Particle formation events were analysed from aerosol number size distribution data collected at a background station in southern Sweden between February 2001 and May 2004. Events occurred on about 36% of all days and were favoured by high global radiation values. The clearest events (class I, 20% of all days) were observed when the formation rate of activated hypothetical clusters around 1 nm diam
Return-to-work and it sustainability after a work site oriented intervention among burnout patients on sick-leave
Combining migration counts from several sites - a way to improve population monitoring by ringing stations.
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
Here we studied whether glial cell line-derived neurotrophic factor (GDNF), given as a single bolus injection before an intrastriatal 6-hydroxydopamine (6-OHDA) lesion, can protect the nigrostriatal dopamine neurons against the toxin-induced damage and preserve normal motor functions in the lesioned animals. GDNF or vehicle was injected in the striatum (25 microg), substantia nigra (25 microg) or
Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites.
Precursors of Novel Gla-Containing Conotoxins Contain a Carboxy-Terminal Recognition Site That Directs gamma-Carboxylation(,).
Yeast ribosomal P0 protein has two separate binding sites for P1/P2 proteins
The ribosome has a distinct lateral protuberance called the stalk; in eukaryotes it is formed by the acidic ribosomal P-proteins which are organized as a pentameric entity described as P0-(P1-P2)(2). Bilateral interactions between P0 and P1/P2 proteins have been studied extensively, however, the region on P0 responsible for the binding of P1/P2 proteins has not been precisely defined. Here we repo
Characterization of a Novel Aberrant Splice Site, 79bp Downstream of Exon 5 in the Human Factor 7 Gene Detected in Patients with Severe Congenital Factor VII Deficiency.
Redesigning the Folding Pathway of a Model Three-helix Bundle Protein by Site-directed Mutagenesis.
Because of their limited size and complexity, de novo designed proteins are particularly useful for the detailed investigation of folding thermodynamics and mechanisms. Here, we describe how subtle changes in the hydrophobic core of a model three-helix bundle protein (GM-0) alter its folding energetics. To explore the folding tolerance of GM-0 toward amino acid sequence variability, two mutant pro
Effects of wind and weather on red admiral, Vanessa atalanta, migration at a coastal site in southern Sweden
Each autumn, large numbers of red admirals migrate throughout northern Europe,flying south, to reach areas with conditions suitable for surviving the winter. We observed the visible butterfly migration at Falsterbo peninsula, the southwesternmost point in Sweden, where red admirals are seen most autumns. ying towards the Danish coast on their way to more southern parts of Europe. Weather parameter
