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Objectives: Efficacy and safety results from the EMERGE (NCT02484547) and ENGAGE (NCT02477800) phase 3 studies of aducanumab in early Alzheimer’s disease (AD) have been published. In EMERGE, but not in ENGAGE, high-dose aducanumab demonstrated significant treatment effects across primary and secondary endpoints. Low-dose aducanumab results were consistent across studies with non-significant differ
It is often a challenge for a child to communicate their pain, and their possibilities to do so should be strengthened in healthcare settings. Digital self-assessment provides a potential solution for person-centered care in pain management and promotes child participation when a child is ill. A child's perception of pain assessment differs when it is assessed using digital or analog formats. As w
Atmospheric mineral dust not only interacts with the climate system by scattering incoming solar radiation and affecting atmospheric photochemistry, but also contributes critical nutrients to marine and terrestrial ecosystems. In a high-resolution analysis of paleodust deposition, peat development and soil dust sources, we assess the interplay between dust deposition and bog development of the Dav
Studies of tree species effects on soils have revealed a significant impact on soil organic carbon (SOC) stocks and the carbon (C) distribution between forest floor and mineral soil, but the underlying mechanisms including the roles of litter traits, soil properties, and microbiome remain unclear. To address this challenge, we tested the effect of six common European tree species on the quality an
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart and respiratory and gastrointestinal tracts, playing important regulatory roles in the cardiovascular and other biological systems. However, the gene
Studies of the long-lived anthropogenic radionuclides 99Tc, 237Np, 239Pu and 240Pu were performed in marine and terrestrial areas contaminated by different accidental and controlled releases of radioactive materials. The three main sources discussed in this thesis are nuclear weapons tests, nuclear reprocessing plants and the Chernobyl accident. Results are mainly based on measurements of environm
Sex chromosome evolution is a fascinating research topic because sex chromosomes provide a snapshot of evolution in many different lineages. Sex chromosomes often cease to recombine and therefore degenerate, and have also often been reshuffled during their evolution from autosomes. It has been discovered that within Sylvioidea passerine species half of chromosome 4a has translocated and fused with
Issue of study: The plastic injection moulding industry has become highly competitive in terms of lead times and pricing, following an increase in low-cost manufacturing from Asia, as a part of the full supply chain. To remain competitive, mould tool manufacturers are looking to complement new tool manufacturing with local after-sales services in countries where their mould tools are being used. U
Vegetation on land is globally taking up about 30% of the CO2 that is emitted by human activities (oceans take up 30%, while 40% remains in the atmosphere). This ability to store carbon in the vegetation and in the soil is very important to mitigate the climate changes, but all land based ecosystems are not carbon sinks. Ecosystems that are losing carbon needs to be further investigated, so we can
People’s ability to learn holds a promise for sustainability as learning is seen to enable change; yet, the prevalence of norms and values in society that reinforce unsustainability may severely challenge this process. The debate on what role learning can play is centered around the question whether people can learn from others and if so, how to enhance it. More precisely, who has to learn what fr
“There is no tool for development more effective than the empowerment of women,” Kofi Annan (UN News Center, 2005). The empowerment of women takes different forms such as pursuit of education, participation in political activities and representation in leadership, equal employment opportunities and wages, access to health care and ability to make decisions on personal reproductive health, economic
Nitrous oxide (N2O) is one of the three primary anthropogenic greenhouse gases. The agricultural sector accounts for 75.7 % of all anthropogenic N2O emissions in Germany (Umweltbundesamt, 2012). Thus, accurately estimating N2O emissions as well as mitigation strategies for N2O are crucial. This study optimizes the process-based model DNDC to simulate N2O emissions by conventional winter wheat and
It was in the early 1980s when Peter Ryan from the University of Cape Town started investigating ecological and conservational factors surrounding the endemic Nesospiza finches in the Tristan da Cunha archipelago, a curious case of resource-driven bird diversification in the Southern Atlantic. Ryan and others suggests for the radiation of Tristan finches to have happened around 400,000 years ago,
Title: Can new companies be in a position to save the world? A qualitative study in how small, newly started companies, with an expressed focus on sustainability, work operatively in their supply chain. Seminar date: 31st of May 2018 Course: FEKH99, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credits Points (UPC) or ECTS Authors: Alexandra Karas
Oslo has until now been divided into the west and east, separated by categories of economic and social class as well as a physical barrier, the river, Akerselva. The west predominantly represents people of middle to upper class, whereas the east represents the middle to lower class people. This division has been formed throughout history, as the river that separates Oslo has been home to industry,
The focus of this thesis is energy justice and sustainability science, and the argument is based on a case study of the Inga dams. Substantial further development of hydropower is planned at the Inga dams, located on the Congo River in the Democratic Republic of Congo. While the project will add macro-economic benefits through the additional power, benefits are limited for people living nearby, a
A section of the Swedish library act stipulates that libraries are to pay specific attention to people with disability. Exhaustion syndrome is a mental disability that in recent years has started to grow rapidly in numbers. This master thesis is mainly aiming to study whether public libraries are welcoming and functional places for people with exhaustion syndrome but it also has a wider scope stud
Teknologins snabba utveckling och de omfattande förändringar som det inneburit för människans levnadssätt är både fascinerande och skrämmande. Allt eftersom tekniken utvecklats har vi kommit att bli mer beroende av elektroniska hjälpmedel, vilket ställt det moderna samhället inför utmaningen att finna nya energikällor och långsiktigt hållbara strategier att utvinna dem på. De senaste decennierna hAs the consumption of energy increase in today’s world, the need for new fuel sources is of central importance. In order to be considered viable in the long run, the new energy sources must provide high efficiency and low environmental impact. The search for alternative fuels and energy extraction methods have become increasingly focused on finding ways to mimic systems found within nature. Oxidor
Denna uppsats undersöker NJA 2023 s. 393 (”Vapenattrappen”), och dess konsekvenser för såväl gällande rätt som domstolarnas rättstillämpning. Domen kom under våren 2023 att kritiseras hårt. I målet stod två män åtalade för försök till vapenbrott, eftersom de påstods ha försökt inneha vapen. Vapnen byttes emellertid ut mot en ofarlig attrapp av polis ca. fyra månader innan de tilltalade dök upp, vaThis paper examines NJA 2023 s. 393 ("The Dummy Weapon"), and its consequences for both current law and practical legal application. The verdict would come to be heavily criticized during the spring of 2023. Two men were prosecuted in the case. They were charged with attempted exceptionally aggravated weapons offence, since they had allegedly tried to possess firearms. The firearms had,
