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Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families

Introduction: A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible be

Analysis of the highly diverse gene borders in Ebola virus reveals a distinct mechanism of transcriptional regulation.

Ebola virus (EBOV) belongs to the group of nonsegmented negative-sense RNA viruses. The seven EBOV genes are separated by variable gene borders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide) IR, and gene overlaps, where the neighboring gene end and start signals share five conserved nucleotides. The unique structure of the gene overlaps and the prese

Structural characterization of human galectin-4 C-terminal domain : Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Human galectin-4 is a lectin that is expressed mainly in the gastrointestinal tract and exhibits metastasis-promoting roles in some cancers. Its tandem-repeat nature exhibits two distinct carbohydrate recognition domains allowing crosslinking by simultaneous binding to sulfated and non-sulfated (but not sialylated) glycosphingolipids and glycoproteins, facilitating stabilization of lipid rafts. Cr

TransCom N2O model inter-comparison : part 1 : assessing the influence of transport and surface fluxes on tropospheric N2O variability

We present a comparison of chemistry-transport models (TransCom-N2O) to examine the importance of atmospheric transport and surface fluxes on the variability of N2O mixing ratios in the troposphere. Six different models and two model variants participated in the inter-comparison and simulations were made for the period 2006 to 2009. In addition to N2O, simulations of CFC-12 and SF6 were made by a

Contrasting changes in taxonomic, phylogenetic and functional diversity during a long-term succession: insights into assembly processes

1. Theory predicts that the processes generating biodiversity after disturbance will change during succession. Comparisons of phylogenetic and functional (alpha and beta) diversity with taxonomic diversity can provide insights into the extent to which community assembly is driven by deterministic or stochastic processes, but comparative approaches have yet to be applied to successional systems. 2.

The ecological impact of oceanic island colonization - a palaeoecological perspective from the Azores

Aim In many cases, human colonization drastically modified the ecosystems of remote oceanic islands before scientists arrived to document the changes. Palaeoecological records before and after human colonization provide insights into the original ecosystems and an assessment of subsequent human impact. We used pollen analysis to compare the impact of 15th century colonization of the Azores with th

Effects of surface characteristics on infiltration patterns in an arid shrub desert

Precipitation is often the sole source of water replenishment in arid and semi-arid areas and, thus, plays a pertinent role in sustaining desert ecosystems. Revegetation over 40 years using mainly Artemisia ordosica and Caragana korshinskii at Shapotou Desert Experimental Research Station near Lanzhou, China, has established a dwarf-shrub and microbiotic soil crust cover on the stabilized sand dun

Primary production of Inner Mongolia, China, between 1982 and 1999 estimated by a satellite data-driven light use efficiency model

Declining biological production as a part of an ongoing land degradation process is considered a severe environmental problem in the dry northern and northwestern regions of China. The aim of this study is to develop and adapt a satellite data-driven gross primary production model called Lund University light use efficiency model (LULUE) to temperate conditions in order to map gross primary produc

EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.

Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.

Arsenic mobilisation in a new well field for drinking water production along the Red River, Nam Du, Hanoi

Arsenic enrichment of groundwater in the Red River (Song Hong) delta in Vietnam was discovered in 1998. Several studies performed in this area found concentrations of As exceeding the WHO-guideline of 10 lg/L. This study focuses on an area south of Hanoi city, Nam Du, where a new well field came into operation in 2004. The new well field is situated on the bank along the Red River in order to faci

Selected research studies from Scandinavia : dedicated to professor Göran Fagerlund on his 60th anniversary November 11, 1997

The book contains selected articles from research in different areas produced by scientists in Scandinavia. However, many of the articles are based upon professor Göran Fagerlund's original ideas. Titles:

1.Cementitious injection grouts - penetration ability (Alemo, J. & Hansson, P.).
2.A disadvantage of high performance concrete and a simple way to avoid it (Alexanderson, J).

No title

1 Överenskommelse om Krislägesavtal Parter Sveriges Kommuner och Landsting och Sobona - Kommunala företagens arbetsgivarorganisation å ena sidan, samt Svenska Kommunalarbetareförbundet, OFRs förbundsområde Allmän kommunal verksamhet jämte i förbundsområdet ingående organisationer, AkademikerAlliansen och till AkademikerAlliansen anslutna riksorganisationer samt Brandmännens Riksförbund, å den andr

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/akademikeralliansen/dokument/avtal-stadgar-pension/krislagesavtal-forhandlingsprotokoll-2019-06-28.pdf - 2026-05-15

Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden

Association studies were carried out on a sample of 87 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms (PvuII, HindIII and Serine447-Stop) at the lipoprotein lipase (LPL) gene locus on among-individual differences in plasma lipid traits and progression of atherosclerosis. Significant li

Indirect effects of lemming cycles on sandpiper dynamics: 50 years of counts from southern Sweden

The bird-lemming hypothesis postulates that breeding success of tundra-nesting geese and waders in Siberia follows the cyclic pattern of lemming populations, as a result of predators switching from lemmings to birds when the lemming, population crashes. We present 50 years of data on constant-effort catches of red knot Calidris canutus and curlew sandpiper C. ferruginea at an autumn migratory stop

Early Paleogene biosiliceous sedimentation in the Atlantic Ocean : Testing the inorganic origin hypothesis for Paleocene and Eocene chert and porcellanite

The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~

Differences in incubation behaviour and niche separation of two competing flycatcher species

Abstract: Food availability sets the stage for incubation behaviour of a female bird and thereby indirectly determines the nest temperature, which in turn affects development and metabolism of avian embryos. Changes in development and metabolism in turn are known to influence offspring’s ability to adjust to environmental changes later in life. However, few studies have investigated the role of in

Bipolar volcanic synchronization of abrupt climate change in Greenland and Antarctic ice cores during the last glacial period

The last glacial period is characterized by a number of millennial climate events that have been identified in both Greenland and Antarctic ice cores and that are abrupt in Greenland climate records. The mechanisms governing this climate variability remain a puzzle that requires a precise synchronization of ice cores from the two hemispheres to be resolved. Previously, Greenland and Antarctic ice

The influence of small-scale variations in isoprene concentrations on atmospheric chemistry over a tropical rainforest

Biogenic volatile organic compounds (BVOCs) such as isoprene constitute a large proportion of the global atmospheric oxidant sink. Their reactions in the atmosphere contribute to processes such as ozone production and secondary organic aerosol formation. However, over the tropical rainforest, where 50 % of the global emissions of BVOCs are believed to occur, atmospheric chemistry models have been

A new retrieval algorithm for soil moisture index from thermal infrared sensor on-board geostationary satellites over Europe and Africa and its validation

Monitoring soil moisture at the Earth'surface is of great importance for drought early warnings. Spaceborne remote sensing is a keystone in monitoring at continental scale, as satellites can make observations of locations which are scarcely monitored by ground-based techniques. In recent years, several soil moisture products for continental scale monitoring became available from the main space age

Rekonstruktion av paleomiljön för området kring den Mesolitiska stenåldersboplatsen vid Sammakko, Norrbotten

En större mängd kvartsavslag och brända ben, upptäckta vid rekognosering (Norrbottens Museum) av hyggesberedda ytor norr om byn Sammakko, c. 40 km SO Gällivare, har tolkats att indikera ett kortvarigt använt boplatsområde. Platsen, liggande c. 100 meter norr Linaälven och i kanten av en nästan igenväxt göl, genomgick arkeologisk förundersökning sommaren 2019. Insamlat material av brända ben och tr