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Changes in amyloid precursor protein and Tau pathology after diffuse traumatic brain injury in the mouse

Traumatic brain injury (TBI) is a common cause of morbidity and mortality in young individuals. Following TBI, the initial injury caused by the head impact is exacerbated by a complex cascade of secondary injury factors leading to increased tissue loss. TBI is an established risk factor for neurodegenerative disorders including Alzheimer disease (AD). In long-term survivors of TBI, increased aggre

System design of a DC based micro grid - A comparison study on the Andaman Islands

The world today stands at a cross roads when it comes to energy and electrical grids. A large part of the worlds population still lacks access to reliable working electricity 24 hours a day. Much of this is in remote and poor parts of the world. For much of the 20th century large centralized AC grids have been the norm to provide people with electricity. But for remote parts of the world including

Spatial and temporal analysis of fecal indicator bacteria concentrations in beach water in San Diego, California

With millions of yearly beach visitors in southern California, beach water quality represents an important factor in public health and ocean dependent economy. Fecal indicator bacteria (FIB) in water is much easier to measure than disease causing organisms but correlation exists between the two. For this reason, FIB concentrations are used to measure recreational water quality and related health r

Quinoline carbohydrate derivatives as galectin-8 inhibitors - From galactose to galactal

Galectins are an old fifteen-member protein family. Every galectin has one or two highly conserved carbohydrate recognition domains (CRDs) through which it binds their mutual ligand galactose. They are involved in various pathways such as signaling, autophagy and immune response. However, they also contribute to pathological functions including fibrosis, metastasis, cardiovascular diseases and dia

Klimatpåverkan av energi- effektiviseringsåtgärder i samverkan med installation av solceller

Från år 2021 ska alla nybyggnationer i Europa vara nära-nollenergibyggnader. Detta innebär att byggnaders energianvändning bör vara låg och i mycket hög grad tillförs i form från förnybara energikällor som produceras på plats eller i närheten. Syftet med de höga energikraven är att påskynda takten för att skapa ett mer energieffektivt byggande. Den minskade energianvändningen tillsam-mans med en ö

Potassium in the Galactic thin and thick discs

Nyfikenhet om stjärnorna och galaxerna runt om oss har fascinerat civilisationer i tusentals år. Rörelsen, ljuset, och mönster av himlakroppar har studerats av astronomer som försker förstå universum och dess utveckling. En fascinerande aspekt av studien av ljuset som emitteras från avlägsna stjärnor är att man observerar det förflutna. Dessutom är det detta ljus och strålning som flyr stjärnorna To understand the evolution of our galaxy, the chemical abundance patterns and trends within the stars of the different regions are explored. The process of synthesizing these elements reveals key details about the way the stars and, therefore, the galaxy formed. This project focused on the element potassium, K, and specifically its absorption line 7699 Å. The local thermodynamic equilibrium (LTE)

Dissolved organic carbon composition and reactivity in arctic Canadian lakes

Freshwater systems are active components of the global carbon cycle and contribute to global CO2 emissions. Freshwater studies in the Arctic are underrepresented, especially regarding lakes and their Dissolved Organic Carbon (DOC) reactivity and composition dynamics. DOC is a main part of DOM (dissolved organic matter), which drives processes central to carbon cycling, influences chemical and biol

Coming for the Money, staying for the Community : an analysis of the NFT community

Non-fungible tokens (NFTs) are a type of cryptocurrency that consist of unique, non-exchangeable tokens, which are traded on a blockchain. These unique tokens are associated with digital assets such as images, art, videos, or music. With the rapid rise of NFTs’ popularity in 2021, a community established around trading, selling, and collecting of NFTs. This study explored the NFT community at larg

Propionibacterium acnes and its phages

Popular Abstract in Swedish Mikroorganismer finns överallt! De klarar av att överleva i extrema miljöer, extrema pH, extrema temperaturer och kan motstå strålning och gift i doser som vi inte skulle överleva. Framförallt klarar mikroorganismer av att överleva i en specifik extrem miljö - människan. Hundratals olika mikroorganismer bor på och i oss, i ett antal som långt överskrider vårt eget cellaMicroorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. Those commensals often fight off more dangerous bacteria and might also directly benefit their host. The human skin harbors several differen

Fracture of the distal radius - outcome, primary surgery and treatment of malunion

A consensus protocol for treatment of distal radius fractures (DRF) has been developed to aid clinicians in treatment decision making. The protocol was evaluated in Paper I using a validated subjective outcome instrument, DASH in 518 consecutive patients. A good final subjective result was achieved with the proposed protocol, regardless of initial severity with a low median DASH score in all group

Assessment of fine-scale plant species beta diversity using WorldView-2 satellite spectral dissimilarity

Plant species beta diversity is influenced by spatial heterogeneity in the environment. This heterogeneity can potentially be characterised with the help of remote sensing. We used WorldView-2 satellite data acquired over semi-natural grasslands on The Baltic island of Öland (Sweden) to examine whether dissimilarities in remote sensing response were related to fine-scale, between-plot dissimilarit

Revisiting the hypothesis that fungal-to-bacterial dominance characterizes turnover of soil organic matter and nutrients

Resolving fungal and bacterial groups within the microbial decomposer community is thought to capture disparate life strategies for soil microbial decomposers, associating bacteria with an r-selected strategy for carbon (C) and nutrient use, and fungi with a K-selected strategy. Additionally, food-web model-based work has established a widely held belief that the bacterial decomposer pathway in so

Cancer risk in amyloidosis patients in Sweden with novel findings on non-Hodgkin lymphoma and skin cancer

Background: Systemic amyloidosis (SSA) is a common form of amyloidosis but it remains often unnoticed because of the slow progression in old patients. The cause for SSA is the accumulation of wild-type transthyretin amyloids in critical tissues. We provide here data showing that SSA may be associated with old-age non-Hodgkin lymphoma.Systemic amyloidoses include immunoglobulin light chain (AL) amy

Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota

Popular Abstract in Swedish Att bär är nyttigt är ett påstående som de flesta känner igen. På butikshyllorna trängs våra nordiska bär med exotiska ”superbär” som utlovar att göra oss friska. Men vilka hälsoeffekter kan egentligen uppnås genom att äta bär? Är vissa bär mer nyttiga än andra? Forskningsresultaten som presenteras i denna avhandling visar att lingon, svarta vinbär och blåbär kan motverThe increasing prevalence of obesity is a worldwide health problem closely linked to diet and lifestyle factors. Obesity is associated with increased risk of several metabolic disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. Hence, there is a great need to identify dietary strategies for the prevention of obesity and related diseases. This thesis invest

Stem and progenitor cells in brain ad breast malignancies

Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. Certain types of neural progenitor cells (NPCs) have been shown to possess a potential of tracking glioma cells in the brain. This makes them pot

Runoff water quality from a green roof and in an open storm water system

Augustenborg storm water system has become well known for its incorporation of urban green spaces. Open storm water system was developed in late 1990s by disconnecting impervious surfaces from combined sewers as a result of flooding problem in the basements after heavy rain events. The open storm water management system consists of open channels and ponds, a small wetland, green infiltration areas

1000 Extra

“1000 Extra” is a project that takes off in the sub optimal conditions that city planning in the 20-th century has left behind for the future. First and foremost looking at the conditions of residential areas planned based on doctrines stemming in modernism, the project proposes desnsifying the not-so-dense areas in Lund, consisting of row houses and other residential buildings in the same categor