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Popular Abstract in Swedish Humana neutrofiler är vita blodkroppar med den kortaste livslängden. Varje dag frisätts det miljoner neutrofiler från benmärgen till blodet. Från blodbanan är neutrofiler de första celler som anländer och samlas i en infekterad vävnad. Neutrofiler är mest kända för deras anti-mikrobiella funktion. Dessa celler är rustade med olika proteiner för att kunna hitta och döda The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders." Therefore, an extensive neutrophil reaction leads to continuous release of toxic metabo

The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. We have focused on the cleavage specificities of HIV-1 protease, HCV NS3 protease and caspases on short oligopeptides or in native prote

In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. The overall aim of this thesis was to develop te

In practice, the catchment hydrologist is often confronted with the task of predicting discharge without having the needed records for calibration. Here, we report the discharge predictions of 10 modellers - using the model of their choice - for the man-made Chicken Creek catchment (6 ha, northeast Germany, Gerwin et al., 2009b) and we analyse how well they improved their prediction in three steps

Popular Abstract in Swedish Beständiga organiska miljögifter, till exempel PCB (Polyklorerade bifenyler), har vållat stora miljöproblem i flera decennier. Dessa föroreningar är kemiskt och biologiskt sett väldigt stabila, vilket gör att de bryts ner mycket långsamt i miljön och alltså kan transporteras långväga med vindar och strömmar. Därför kan man hitta PCB över hela jorden, även i områden där Persistent organic pollutants (POPs) pose serious threats to our global environment. These compounds have high chemical and biological stability and they are also very lipophilic. These characteristics not only render POPs the ability to spread widely and pollute remote areas, they also make them prone to accumulate in adipose tissues of living organisms. Consequently, it is important to monitor P

Adsorption of cationic polyelectrolytes onto polystyrene latices was studied as function of polymer chemical composition and molecular weight, polymer and surface charge density and ionic strength. The ratio between polymer charges and surface charges was close to one when distances between polymer and surface charges were equal. Overcompensation of the surface charge was obtained at higher polyme

Steady state and time-resolved absorption and fluorescence spectroscopy have been used to investigated the energy transfer in photosynthetic purple bacteria. Picosecond light pulses were used in measurements of Rb. sphaeroides WT and a LH1-deleted mutant, demonstrating that the energy trapping into the reaction center in both species occur on the same time-scale, and that the excitation energy is

Popular Abstract in Swedish Alla friska människor har 46 kromosomer, 23 av dessa härstammar från modern och 23 från fadern. Kromosomer är långa kedjor av nukleinsyror som innehåller den genetiska informationen (arvsanlagen) som behövs för att ett befruktat ägg skall kunna utvecklas till en individ bestående av miljontals celler med mycket specialiserade och avancerade uppgifter. Den här utvecklingThe cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. This characterization is based on the expression of intracellular markers such as the recombination activating genes 1 and 2(Rag 1 and Rag 2), the terminal deoxynucleotidyl t

Popular Abstract in Swedish Vårt immunsystem är uppbyggt runt två typer av celler som har som uppgift att försvaraoss mot infektioner. T lymfocyterna står för det cellmedierade immunförsvaret som är speciellt viktigt för att bekämpa virusinfektioner med B lymfocyterna har som uppgift att producera antikroppar. Antikroppar finns i alla kroppsvätskor och kan interagera med toxiner, virus och bakteriEach immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. Therefore, the activity of other co-stimulatory elements is required. This investigation has focused on the study

Popular Abstract in Swedish Syftet med denna avhandling är att undersöka vilken roll synlighet spelar i skapandet och utmanandet av tillhörighet till politiska gemenskaper. Baserat på en empirisk studie av ryska medier under 2010-talet föreslås ett sätt att teoretiskt begreppsliggöra förhållandet mellan synlighet och tillhörighet, som utgår från idén att vad som blir synligt för en publik och hur,The purpose of this dissertation is to explore the role of visibility in the production and contestation of belonging to political communities. On the basis of an empirical enquiry of Russian media during the 2010s, a theoretical conceptualization of the relation between visibility and belonging is suggested, starting in the idea that what becomes visible to publics and how, and what is rendered i

Popular Abstract in Swedish Symtomgivande nervrots påverkan i halsryggen diagnostiseras via sjukhistoria, klinisk undersökning och magnetkamera undersökning av halsryggen (MRI). Hos flera av patienterna som genomgår denna utredning infinner sig svårigheter att identifiera den/de nervrötter som är ansvariga för patientens smärta. Detta beror på att den kliniska undersökningen och undersökningen medCervical radiculopathy is diagnosed by history, clinical examination of the patient and magnetic resonance imaging (MRI) of the cervical spine. In many of the patients undergoing this diagnostic strategy, the nerve root/roots responsible for the radicular pain is difficult to define as clinical examination and MRI investigation does not provide information enough. The information from transforamin

In the evolution of bird migration, partial migration is assumed to be an important intermediate step between migration and residency. Partial migration is characterised by the existence of both migratory and resident individuals in a given population. Compared to regular migration, relatively little is known about partial migrants and their migratory performances. In my thesis, I have studied th

Sub-micrometer atmospheric aerosol particles were studied in the Amazon region, 125 km northeast of Manaus, Brazil (-1degrees55.2'S, 59degrees28.1'W). The measurements were performed during the wet-to-dry transition period, 4-28 July 2001 as part of the LBA (Large-Scale Biosphere Atmosphere Experiment in Amazonia) CLAIRE-2001 (Cooperative LBA Airborne Regional Experiment) experiment. The number si

The Southern Ocean is split into several biogeographical provinces between convergence zones that separate watermasses of different temperatures. Recent molecular phylogenies have uncovered a strong phylogeographic structure among rockhopper penguin populations, Eudyptes chrysocome sensu lato, from different biogeographical provinces. These studies suggested a reclassification as three species in

PURPOSE: To evaluate, preclinically, the potential for dose escalation of continuous, hyperfractionated, accelerated radiation therapy (CHART) for non small-cell lung cancer (NSCLC), we examined the strategy of omission of elective nodal irradiation with and without the application of three-dimensional conformal radiation technology (3DCRT). METHODS AND MATERIALS: 2D, conventional therapy plans we

1 Species-rich semi-natural grasslands in Europe developed during prehistoric times and have endured due to human activity. At the same time, intensive grassland management or changes in land use may result in species extinction. As a consequence, plant diversity in semi-natural calcareous grasslands may be related to both historical and current human population density. 2 We hypothesize that cur