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Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s contribution to high-risk disease are not completely understood. Herein, we implemented an integrative approach combining publicly available RNA-S

Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. Tissue microarrays from 629 resected primary lung cancers and 422 resected pul

Background: Skill and experience of surgeons are likely to influence the incidence of surgical wound complications (SWC) after open lower limb revascularization. Differences in SWC between surgeons with predominantly endovascular or open vascular surgical profiles could be expected. The aim of this study was to compare SWC rates after elective open vascular surgery between primarily endovascular a

This dissertation is a contribution to the ‘cultural turn’ in the multidisciplinary field of surveillance studies. Its objective is to advance knowledge about how surveillance is perceived as bodily, emotional, and multisensory experiences - explored and conceptualized here as ‘atmospheres of surveillance’. The overarching argument is that surveillance contains and co-produces atmospheres. The stu

Inherited resistance to activated protein C (APC-resistance) and protein S deficiency are associated with functional impairment of the protein C anticoagulant system, resulting in lifelong hypercoagulability andincreased risk of thrombosis. APC-resistance is the most common genetic cause of thrombosis being present in 20% to 60% of thrombosis patients.A linkage study was performed in a large throm

Accurate evapotranspiration (ET) data are required for many hydro-meteorological applications. Compared with the traditional evaluation that requires in-situ measurements, the triple collocation (TC) technique estimates geophysical product errors without the need for ground truth, which is especially suitable over large areas lacking a dense in-situ network. However, violations of the zero-error c

Background: Several biochemical markers in blood correlate with the magnitude of brain injury and may be used to predict neurological outcome after cardiac arrest. We present a protocol for the evaluation of prognostic accuracy of brain injury markers after cardiac arrest. The aim is to define the best predictive marker and to establish clinically useful cut-off levels for routine implementation.

Popular Abstract in Swedish Så gott som alla metaller reagerar vid normala omständigheter med syret i luften och oxideras, vilket förändrar materialets egenskaper. T.ex. rostar järn efter hand, något som alla bilägare är bittert medvetna om. Oxider behöver dock inte vara negativa, utan kan även fungera som barriärer mot fortsatt korrosion, isolerande skikt i mikroelektronikkomponenter m.m. FöljaktThe oxidation of Rh, Pd and Pt is studied under conditions ranging from ultra high vacuum to ambient pressures, with emphasis on a complete understanding of the geometry of the various oxide structures found. The investigations use a combination of various experimental methods, including high resolution core level spectroscopy, low energy electron diffraction, surface x-ray diffraction and scannin

Popular Abstract in Swedish Denna avhandling behandlar ämnet känselåterkoppling i handproteser. Att mista sin hand är en traumatisk upplevelse och den som har mist sin hand förlorar både känsel och motorik. En rudimentär greppfunktion kan återskapas genom att använda en handprotes. Nya och avancerade proteser som kontrolleras med hjälp av muskelsignaler finns numera på marknaden och dessa myoelektAmputation of the hand implies the loss of the ability to grasp and the ability to "feel". The grasping function can be primitively restored using an active prosthesis. Multi­articulating electrically powered hands have recently made their way to the market and these hands provide enhanced grasping and gripping capabilities. However, these hands provide no direct and conscious sensory feedback to

Change is sweeping through the world of museums, technologically, financially, and ideologically, impacting on the sociocultural evolution of their roles and status. We seek to contribute to ongoing reflections by offering a conceptual framework that links museums with democratic theory, to citizenship and its practices – a domain that is also in notable transition. We connect concretely with the

Introduction: Giant-cell tumor of bone (GCTB) is a locally aggressive histologically benign neoplasm with a less common malignant counterpart. Longitudinal data sources on GCTB are sparse, limited to single institution case series or surgical outcomes studies. The Swedish Cancer Registry is one of the few national population-based databases recording GCTB, representing a unique source to study GCT

Environmentally safe disposal of urban waste is a global concern that recently gained a new dimension through the lens of Environmental Justice, with a growing literature showing correlation between the placement of waste facilities and disadvantaged groups in society. This thesis seeks to verify whether landfills in the city of São Paulo are located in regions where socially and economically vuln

Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin

Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis

Adolescent girls are particularly susceptible to iron deficiency due to increased iron requirements during the pubertal growth spurt, combined with iron loss following menarche. This study aimed to investigate the prevalence of heavy menstrual bleeding in an adolescent population using the SAMANTA questionnaire and to explore its relationship with dietary habits and iron deficiency. This cross-sec

The Cerrado sensu stricto, so-called wooded Cerrado, is one of the many phytophysiognomies of the undisturbed Brazilian Cerrado ecoregion holding a biodiversity hotspot towards an extensive area. Thus, such land is under constant land use and cover changes mainly due to the demand for agriculture land, sector with the highest consumption of available freshwater in this ecoregion. This underscores

Study Region 103 FLUXNET2015 flux towers distributed across diverse climatic and ecological regions. Study Focus Accurate estimation of evapotranspiration (ET) is critical for understanding regional ecohydrological processes. Physically based models such as the Penman-Monteith-Leuning (PML) model are robust but often constrained by fixed parameterization schemes, while data-driven approaches such

Old-growth forests uniquely support biodiversity while serving as some of the planet's most important carbon stocks. The influence of tree and stand age on carbon flux dynamics remains debated—an urgent question as climate-driven disturbances may reshape forest age structures and in situ carbon storage. To clarify these relationships in Fagus sylvatica , systems, we examined a unique dataset of 3,