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The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main producer of extracellular matrix molecules such as collagen, versican, perlecan, biglycan, and decor
The two major aims of this study are (1) To test the performance of the Landscape Reconstruction Algorithm (LRA) to quantify past landscape changes using historical maps and related written sources, and (2) to use the LRA and map reconstructions for a better understanding of the origin of landscape diversity and the recent loss of species diversity. Southern Sweden, hemiboreal vegetation zone. The
This dissertation discusses aspects of the syntax of Övdalian, a variety spoken by ca. 2,500 people in the province of Dalecarlia in Sweden. Initially, an overview of the history and current status of the language of Älvdalen is given, and the focus of the dissertation is on certain syntactic phenomena that have been well studied from a comparative and diachronic perspective in other Scandinavian
Given the increasing interest in the association between exposure to air pollution and adverse health outcomes, the development of models that provide accurate spatio-temporal predictions of air pollution concentrations at small spatial scales is of great importance when assessing potential health effects of air pollution. The methodology presented here has been developed as part of the Multi-Ethn
An initial model in the crystallographic structure determination process, usually contains many errors. To produce an accurate model, one must carry out several cycles of crystallographic refinement. Because of the limited resolution typically obtained for biomolecules, the experimental data are usually supplemented by some sort of chemical information, typically in the form of a molecular-mechani
Popular Abstract in Swedish Förmågan att ha tillgång till energi oberoende av ett varierande födointag är livsavgörande. Kroppen har därför på ett högst effektivt sätt löst detta genom att lagra energi i form av fett i fettceller, vilka finns i fettväven. Dessa fettdepåer, vilka utgörs av triglycerider (en triglycerid består av ett glycerol med tre påkopplade fettsyror), byggs upp då födointaget äTriglycerides in the adipocyte are hydrolysed by means of three consecutive reactions through the combined action of two lipases: hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). HSL catalyses the first and rate-limiting step, i.e. the hydrolysis of triglycerides to diglycerides, and the subsequent hydrolysis of diglycerides and monoglycerides. However, MGL is needed to assure comple
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA I blodet finns en mängd olika celltyper som alla har sin specifika funktion. De röda blodkropparna (erytrocyterna), transporterar livsnödvändigt syre till kroppens alla vävnader. De vita blodkropparna (leukocyterna), vilka inkluderar lymfocyter, monocyter och granulocyter, deltar i kroppens immunförsvar och skyddar kroppen Hematopoiesis is a highly complex process by which a range of specialized blood cells are generated from a small pool of multipotent stem cells in the bone marrow. The survival, proliferation, and differentiation of hematopoietic stem cells are tightly regulated by both soluble and membrane-bound cytokines produced within the bone marrow microenvironment. Kit Ligand (KL) and Flt3 Ligand (FL) are t
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Hindlimb ischemia is an unmet medical need, especially for those patients unable to undergo vascular surgery. Cellular therapy, mainly through mesenchymal stromal cell (MSC) administration, may be a potentially attractive approach in this setting. In the current work, we aimed to assess the potential of the combination of MSCs with a proangiogenic elastin-like recombinamer (ELR)-based hydrogel in
This study is about Wikipedia which defines itself as a free online encyclopaedia. Our chief interest lies in the debate and the controversy which has arisen around Wikipedia. After reading critical articles concerning Wikipedia we found that the debate for most parts had one identifiable theme namely the question whether Wikipedia is an encyclo-paedia or not. Encyclopaedia as a term and a phenom
Today, "the digital library" is the common way of describing a managed collection of information, with associated services, stored in digital formats and accessible over a network. Digital libraries have mainly been developed at research libraries, but during the last few years public libraries have started to offer similar services. The aim of this Master's thesis is to study how t
The present study investigated second language (L2) learners’ processing of filler-gap dependencies and tested the implications of Clahsen and Felser’s (2006) shallow structure hypothesis according to which L2 learners underuse syntactic information during the processing of these sentence types. Advanced L2 learners of English (native Swedish speakers) listened to English sentences with object-rel
This study constitutes a preliminary survey within the project "Lake and groundwater paleohydrology of the Vomb plain, southern Sweden, for quantitative paleoclimatic calibration". The aim of the study is to describe the Holocene sediment stratigraphy of the former lakes Fönesjön and Kalvsjön (Kalvs mosse), and furthermore to describe and date stratgraphical indications of climatically c
Albert-László Barabási, from the introduction to his book titled Linked: the new science of networks, “Just as diverse humans share skeletons that are almost indistinguishable, we have learned that these diverse maps follow a common blueprint. A string of recent breathtaking discoveries has forced us to acknowledge that amazingly simple and far-reaching natural laws govern the structure and evolut
X-ray crystallography is the main source of atomistic information on the structure of proteins. Normal crystal structures are obtained as a compromise between the X-ray scattering data and a set of empirical restraints that ensure chemically reasonable bond lengths and angles. However, such restraints are not always available or accurate for nonstandard parts of the structure, for example substrat
Background & Aims: Few patients with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBDs) are exposed to tumor necrosis factor (TNF) antagonists because of the often mild symptoms of IBD. We assessed the effects of anti-TNF agents on liver function in patients with PSC and IBD, and their efficacy in treatment of IBD. Methods: We performed a retrospective analysis of 141
Objectives: Accurate and reliable diagnostics are crucial as histopathological type influ-ences selection of treatment in lung cancer. The aim of this study was to evaluate real-world accuracy and use of immunohistochemical (IHC) staining in lung cancer diagnostics. Materials and Methods: The diagnosis and used IHC stains for small specimens with lung cancer on follow-up resection were retrospecti
Understanding the emergence and development of coastal adaptations is a central theme in the archaeology of Maritime Northeast Asia. The capacity to harvest, store and share aquatic resources offered a novel economic strategy that could support greater sedentism and new forms of social life. In turn, growing reliance on the exploitation of rich coastal resources wouldhave generated powerful incent
The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of caro
