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Metabolic Engineering of the Central Carbon Metabolism in Streptococcus thermophilus for Enhanced Exopolysaccharide Production
The lactic acid bacterium, Streptococcus thermophilus, is used in the dairy industry in mixed cultures with Lactobacillus delbrueckii subsp. bulgaricus for the production of yoghurt. Many strains of S. thermophilus produce exopolysaccharides (EPSs) which affect the texture and viscosity of fermented food products. However, the production of EPSs by S. thermophilus is low and variable, and better k
Glucagon-like peptide 1 (GLP-1) analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction
Aims: To evaluate the effects of adding glucagon-like peptide-1 (GLP-1) analogue therapy to insulin on glycated hemoglobin (HbA1c), weight, insulin dosage, treatment satisfaction, and risk of hypoglycaemia. Methods: Type 2 diabetes patients with insulin therapy receiving a GLP-1 analogue at 4 Swedish centers were studied. Hypoglycemia was evaluated using glucometers and patient self-report. The Di
Long-term prognosis of early-onset breast cancer in a population-based cohort with a known BRCA1/2 mutation status.
All women in the South Sweden Health Care Region with breast cancer diagnosed aged less than 41 during the period between 1990 and 1995 were contacted in 1996 and offered germline mutation analysis of the BRCA1 and BRCA2 genes. Mutation carriers (n = 20) were compared with noncarriers (n = 201) for overall survival (OS) and risk of contralateral breast cancer (CBC). Mutation carriers were younger
“Use” discourses in system development: Can communication be improved?
This paper aims to provide a basis for renewed talk about "use" in computing. Four current "discourse arenas" are described. Different intentions manifest in each arena are linked to failures in "translation", different terminologies crossing disciplinary and national boundaries non-reflexively. Analysis of transnational use discourse dynamics shows much miscommunication. Conflicts like that betwe
Novel Nano-Sized MR Contrast Agent Mediates Strong Tumor Contrast Enhancement in an Oncogene-Driven Breast Cancer Model.
The current study was carried out to test the potential of a new nanomaterial (Spago Pix) as a macromolecular magnetic MR contrast agent for tumor detection and to verify the presence of nanomaterial in tumor tissue. Spago Pix, synthesized by Spago Nanomedical AB, is a nanomaterial with a globular shape, an average hydrodynamic diameter of 5 nm, and a relaxivity (r1) of approximately 30 (mM Mn)-1
Occurrence of the hermit beetle (Osmoderma eremita), in Sweden.
We have compiled data on the occurrence of a threatened beetle, Osmoderma eremita, in Sweden. The species inhabits tree hollows with wood mould. The data were compiled from field surveys conducted in 1993-2003, using pitfall traps at 401 localities and using wood mould sampling at 104 localities. We have also gone through published data and all larger Swedish museums and registered old records. O.
Extracellular Glutathione Peroxidase - Purification, Immunoassay, Nutritional Regulation and Clinical Aspects
Extracellular glutathione peroxidase (eGSHPx) is a selenoprotein catalysing the reduction of hydrogen peroxide, organic peroxides and lipid peroxides in the presence of glutathione. A scaled-up purification procedure for obtaining eGSHPx from human plasma was established based on ammonium sulphate fractionation, hydrophobic interaction chromatography, ion-exchange chromatography and gel chromatogr
On Categorizing the IS Research Literature: User Oriented Perspective
The purpose of this paper is to propose a new approach for categorizing the body of knowledge captured in the existing literature, past and present in such a way that contributions to the use side of systems development are made explicit. The new twist of this approach is that it seeks to bridge the most prevalent divides currently fragmenting the IS literature by offering an integrative classific
Monitoring insect defoliation in forests with time-series of satellite based remote sensing data - near real-time methods and impact on the carbon balance
Popular Abstract in Swedish Skogar är av stor betydelse ur klimatsynpunkt på grund av deras stora förmåga att binda kol. Skogar på de nordligare breddgraderna spelar en viktig roll med sitt stora kolupptag, men eftersom dessa nordliga skogar troligen kommer att påverkas av klimatförändringarna i hög grad är det osäkert hur framtida kolupptag kommer att utvecklas. Ett varmare klimat kommer sannolikForests are of major importance to climate change mitigation due to their strong capacity to sequester carbon. Nearly half of the terrestrial carbon is stored in forests, and forests contribute to half of the terrestrial primary productivity, with forests in the mid- and high latitude ecosystems as major contributors. These high latitude forests are, however, projected to be strongly influenced by
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Diagnostic reference levels are the main and the most effective tools of optimization of the radiation protection of patients from medical exposure. Diagnostic reference levels should be established based on theresults of dedicated dose surveys, allowing evaluating typical patient dose distributions in a selected dose quantity for the selected X-ray examinations. The aim of the current study was t
Full-field Electroretinography in Age-related Macular Degeneration : can retinal electrophysiology predict the subjective visual outcome of cataract surgery?
Purpose: Predicting the visual gain from cataract surgery when the main cause of vision loss is age-related macular degeneration may be difficult and warrants the need for an objective predictor of subjective outcome. Full-field electroretinography is an objective measure of overall retinal function. We therefore wanted to study if full-field electroretinography can predict subjective visual outco
Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data
Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-fa
Alcohol Use Disorder and Risk of Suicide in a Swedish Population-Based Cohort
OBJECTIVE: The authors examined the association between alcohol use disorder (AUD) and risk of suicide, before and after accounting for psychiatric comorbidity, and assessed the extent to which the observed association is due to a potentially causal mechanism or genetic and familial environmental confounding factors that increase risk for both. METHODS: Longitudinal population-wide Swedish medical
Radial Velocities Without Spectroscopy -Astrometric determination of stellar radial motion
Popular Abstract in Swedish Stjärnors radialhastigheter har i mer än ett sekel haft betydelse för studiet av Vintergatans och stjärnhoparnas kinematik. Radialhastigheten är den hastighet en stjärna, eller ett annat objekt, har längs synlinjen från en given observatör. Hittills har radialhastigheter bestämts med hjälp av spektroskopi, genom att observera spektrallinjer vars vilovåglängder är kända.This work demonstrates the determination of absolute stellar radial velocities from geometrical principles, i.e. using astrometry. Such `astrometric radial velocities' are obtained independently of spectroscopic information. While spectroscopic radial velocities are affected by line shifts from astrophysical processes on the stellar surfaces, by gravitational redshift and various other effects, as
Impact of type 2 diabetes on complications after primary breast cancer surgery : Danish population-based cohort study
Background: Knowledge is sparse on the impact of type 2 diabetes (T2D) on surgical outcomes after breast cancer surgery. This study investigated the association between T2D and risk of complications after primary breast cancer surgery, and evaluated the biological interaction between T2D and co-morbidities. Methods: Using the Danish Breast Cancer Group clinical database, a cohort of all Danish wom
Strategy games; on survival and reproduction
Classical evolutionary life history concerns questions such as optimal timing of maturation, life span and number of offspring. These questions have mostly been studied theoretically under the assumption that the environment is stable and without taking into account frequency and density dependence. Life history theory is the basis for my thesis, in which I have studied the evolution of different
Introduction
Emergency readmission following acute upper gastrointestinal bleeding
OBJECTIVE: To assess the occurrence, clinical predictors, and associated mortality of all-cause emergency readmissions after acute upper gastrointestinal bleeding (AUGIB). PATIENTS AND METHODS: All patients with AUGIB from an area of 600 000 inhabitants in Sweden admitted in a single institution in 2009–2011 were retrospectively identified. All medical records were scrutinized and relevant data (s
Resilience and Risk for Alcohol Use Disorders : A Swedish Twin Study
Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale du
