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microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. It has also been shown that alterations in levels of specific miRNAs have implications in var
B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prosp
Popular Abstract in Swedish Vår kropp består av olika celler som kommunicerar med varandra genom signalering. Cellerna tar emot signaler från omgivningen med hjälp av proteiner som sätter sig fast på deras yta genom mottagare, så kallade receptorer. När receptorerna får signaler skickas de vidare in i cellkärnan där det bestäms hur cellen ska agera. Tyrosinkinasreceptorer är proteiner som sitter pFLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. FLT3 mutations cause constitutive activation of intrinsic tyrosin
UHT direct steam injection and steam infusion are widely used; however there is no comparison of their impact on milk components. This study evaluates the structural changes at different steps during the UHT processing of whole milk in a full-scale UHT plant by transmission electron microscopy (TEM) and particle size measurements, and follows the enzymatic activity. The results of structural anal
Popular Abstract in Swedish Diabetes är en folksjukdom där c:a 350000 människor i Sverige är drabbade. Fotsår är en vanlig komplikation vid diabetes, och sådana svårläkta sår leder till c:a 700 diabetesrelaterade amputationer årligen. Såväl såren som amputationssituationen orsakar funktionshinder, smärta, sociala bekymmer samt psykisk stress för dem som drabbas. Att utveckla nya och förbättrade beDiabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. We stipulated that by inducing diabetes in yorkshire pigs, wound healing would be delayed and exhibit abnormalities similar
Background: There is a great variability in licit prescription drug use in the population and among patients. Factors other than purely medical ones have proven to be of importance for the prescribing of licit drugs. For example, individuals with a high age, female gender and low socioeconomic status are more likely to use licit prescription drugs. However, these results have not been adjusted for
Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r
Popular Abstract in Swedish Medievärlden är idag föremål för drastiska förändringar. Förutom de traditionella medierna såsom böcker, TV och radio, introduceras interaktiva digitala medier. Dessa förändringar berör inte mins barnens och ungdomarnas liv. Allteftersom de får tillgång till sofistikerade elektroniska och digitala medier blir deras fritid alltmer teknifierad. Vi är all medvetna om hur mWe are all aware of how many different media have become a familiar equipment in the home, perceived as any other furnityre. The media have become more or less unconsciously intertwined in everyday routines. As the media environment is continously in a phase of transformation, it is crucial to gain knowledge about children´s and adolescents´own understanding and interpretation of their mediarelate
OBJECTIVES: To describe the drug use in epilepsy and Parkinson's patients living in nursing homes and to evaluate the impact of multi-speciality team intervention on health-related quality of life, activities of daily living (ADL) and confusion state. METHODS: Nursing home residents with epilepsy or Parkinson's disease in the county of Skåne in Sweden were identified. From 119 nursing homes, 262 p
The present study examined the influences of the muscle contraction (MCP) and relaxation (MRP) phases, as well as systole and diastole, on the blood velocity profile and flow in the conduit artery at different dynamic muscle contraction forces. Eight healthy volunteers performed one-legged dynamic knee-extensor exercise at work rates of 5, 10, 20, 30, and 40 W at 60 contractions per minute. The ti
Popular Abstract in Swedish I avhandlingen beskrivs och analyseras 12 kvinnors skolkarriärer och deras möte med svensk skola. Syftet är att identifiera och belysa mönster, processer och vändpunkter på olika nivåer som utifrån kvinnornas perspektiv mobiliserat respektive begränsat deras skolkarriärer. Kvinnorna kom som flyktingar till Sverige i tonåren och återupptog sin avbrutna skolgång i svenskThe purpose of this thesis is to describe and analyse some foreign women s perspectives on their first meeting with the Swedish school and to identify and illuminate patterns and processes on different levels that facilitate respectively obstruct the development of their school careers. The women arrived in Sweden in their teens and attended Swedish upper secondary school, completed their educatio
Abstract in UndeterminedObjective To investigate acute posttraumatic reactions and forms of coping to the September 11 attack. Method A Web TV nationwide, representative sample of individuals 13 years or older (N=3134) was evaluated within three weeks of the attack. Measures included the SASRQ, the brief version of the COPE, and questions about demographics and attitudes toward the attackers. Resu
In the last decades there has been an increased influence of ethnomusicology in music education research. This is reflected in the activities of international associations such as International Society for Music Education (ISME), International Music Council (IMC) and Cultural Diversity in Music Education (CDIME), as well as in a growing body of research (e.g. Drummond, 2005; Schippers, 2010; Szego
Objective. While the prevalence of radiographic thumb carpometacarpal (CMC1) osteoarthritis (OA) is well-described, little is known about clinically symptomatic disease presenting to physicians for care. We sought to determine the prevalence of doctor-diagnosed CMC1 OA. Methods. Using health care data from Skane in southern Sweden (population 1.24 million), we identified all adults ages >= 20 year
In most cases, direct X-ray fluorescence (XRF) analysis of solutions entails technical difficulties due to a high X-ray scattering background resulting in a spectrum with a poor signal-to-noise ratio (SNR). Key factors that determine the sensitivity of the method are the energy resolution of the detector and the amount of scattered radiation in the energy range of interest. Limiting the width of t
PurposeIncumbent retail organisations need to develop new capabilities to adapt with the increasingly competitive retail landscape. Despite the growing relevance of innovation in retail practice, the strategic management of innovation in retailing is still vastly under-researched. This explorative study thus aims to investigate how incumbent retail firms can organise for innovation from an organis
Background: This study aimed to determine the robustness of the impact of immigration on risk for alcohol use disorder (AUD) using different measures, designs, and immigrant regional cohorts. Methods: The analytic sample included all individuals born between 1950 and 1990 and registered in Sweden from 1973 to 2017. Using Cox regression models, we examined the risk for AUD from Swedish nationwide r
