Filtyp
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development. However, comprehensive understanding of how matrisome factors control cells in vivo is lacking. Here we show that specific matrisome factors act individually and collectively to control
It is a common strategy to predict oncogenes by differential analysis between somatic mutations and background mutations. Most previous methods only utilize mutations in the cancer population to model its background mutation, which have an obvious bias. A recent method, DiffMut, improves this issue by conducting differential mutational analysis with both mutations in the cancer population and the
The European Council Directive 2013/59/Euratom (BSS Directive) includes optimisation of treatment with radiotherapeutic procedures based on patient dosimetry and verification of the absorbed doses delivered. The present policy statement summarises aspects of three directives relating to the therapeutic use of radiopharmaceuticals and medical devices, and outlines the steps needed for implementatio
Researchers often aim to make correct inferences both about that which is actually studied (internal validity) and about what the results generalize to (external validity). The language of internal and external validity is not used by everyone, but many of us would agree that intuitively the distinction makes a lot of sense. Two claims are commonly made with respect to internal and external validi
The state-of-the-art in development tools today provides users with a large number of both syntactic and semantic services, such as syntax highlighting, name completions and refactorings. Preferably, every language should have sophisticated tool support, but unfortunately, the manual task of tool development is both time-consuming and error-prone, making it too costly for small language communitie
Gamma-ray bursts (GRBs) are intense, short-lived bursts of gamma-ray radiation observed up to a high redshift (z ∼ 10) due to their luminosities. Thus, they can serve as cosmological tools to probe the early Universe. However, we need a large sample of high-z GRBs, currently limited due to the difficulty in securing time at the large aperture telescopes. Thus, it is painstaking to determine quickl
Matchfixning är ett är problem som hotar att rubba fotbollens integritet fundamentalt. Fotbollens värdegrund är och ska alltid vara kännetecknat av tävling på lika villkor vilket ska locka fram det bästa av utövarna. Matchfixning riskerar att omkullkasta den här värdegrunden. Vadhållningsrelaterad matchfixning innebär att en idrottslig aktör medvetet underpresterar i en tävling, i enlighet med en Match fixing is an issue that threatens to fundamentally distort the integrity of football. The basic principles and common values of football are, and should always be, characterized by competition on equal terms, designed to bring the players to perform at their absolute top. Match fixing puts this core value at risk of being toppled over. Match fixing related to betting implies that an athlete
The development and manufacturing process for Integrated Circuits (ICs) has become complex and globally distributed. System integrators use a mix of custom made logic with third-party Intellectual Property (IP) blocks, untrusted software tools, and external actors for manufacturing, post-production test, and validation. The many untrusted actors involved throughout the IC’s lifetime become a secur
Popular Abstract in Swedish Alla har vi väl någon gång varit med om att datorer, dataprogram och datasystem inte fungerar som vi har tänkt oss. Inte sällan inträffar det fel och konstigheter som kan vara frustrerande och, i värsta fall, direkt farliga. Många gånger undrar man hur ett visst program eller system skall användas och hur de som har designat och byggt det har tänkt och resonerat. I sto
Background. To study group B streptococcus (GBS) colonisation in parturients and infants in relation to obstetric outcome and to define serotypes and antibiotic resistance in GBS isolates acquired. Methods. A population-based, national cohort of parturients and their infants was investigated. During 1 calendar week in 2005 all women giving birth (n=1,754) were requested to participate in the study
Background: Smoking and the use of smokeless tobacco have a detrimental impact on general and oral health. The relationship to dental caries is however still unclear. As caries is a multi-factorial disease with clear life-style, socio-economic and socio-demographic gradients, the tobacco use may be a co-variable in this complex rather than a direct etiological factor. Our aim was to analyze the im
Objectives: The aim of this study was to explore the prevalence of eating difficulties and malnutrition among persons in hospital care and in special accommodations. Design: The cross-sectional observational study was performed in Nov. 2005. Setting: Hospitals and special accommodations. Participants: Out of 2945 persons, 2600 (88%) agreed to participate (1726 from special accommodations and 874 f
BackgroundPrediction of a woman's risk of a spontaneous preterm delivery (PTD) is a core challenge and an unresolved problem in today's obstetric practice. The objective of this study was to develop prediction models for spontaneous PTD (<37 weeks). MethodsA population-based register study of women born in Sweden with spontaneous onset of delivery was designed using Swedish Medical Birth Register
The properties of micro-porous ceramics are studied in the present work using a tunable diode-laser-based setup. The relative optical porosity is retrieved by using gas in scattering media absorption spectroscopy (GASMAS) - which yields the path length travelled by photons through the gas-filled pores - and frequency domain photon migration (FDPM) - which evaluates the mean optical path length (MO
The feasibility of exploiting genomic information for individualized treatment of polygenic diseases remains uncertain. A genetic variant in ADRA2A, which encodes the α2A-adrenergic receptor (α2AAR), was recently associated with type 2 diabetes. This variant causes receptor overexpression and impaired insulin secretion; thus, we hypothesized that blocking α2AAR pharmacologically could improve insu
Popular Abstract in Swedish Värmebehandling (termoterapi) av tumör baseras på kunskap om den celldödande effekten av värme. Den har begränsats av svårigheten att kontrollera temperaturutbredningen så att en selektiv och tillräcklig effekt erhålls, och detta gäller särskilt djupt belägna tumörer. Interstitiell laser termoterapi (ILT) med Nd:YAG laser är en ny behandlingsform, som ger de tekniska föInterstitial laser thermotherapy (ILT) is a method well suited for selective local destruction of malignant tumours. In the present work, a laser thermotherapy system based on feedback temperature control of energy delivery (through computerised feedback system) was developed. Temperature control was excellent in experiments without carbonization and with preserved light penetration, whereas tempe
The legume goat's rue (Galega orientalis) and its microsymbiont Rhizobium galegae have an unusually strict host-bacteria specificity. The reason for this is not known. We have identified and analysed six genes in G. orientalis assumed to be involved in the recognition processes between legumes and rhizobia. The genes were isolated from a library made from nodulating roots. The genes were identifie
