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“It is very convenient when it works – successes and challenges with welfare technology” - a qualitative study

Welfare technology (WT) use is increasingly advocated to facilitate aging in place. However, it remains unclear how older adults and homecare staff perceive these digital technologies in practice. This qualitative study investigated the ways in which current WT either facilitated or fell short in supporting older adults in their daily lives and homecare staff at work. Four key themes were develope

"That fluidity out there" - Epiphanies and the Sea in Virginia Woolf's "To the Lighthouse"

Epiphanies constitute an essential aspect of Woolf's fiction, as well as her ideas about fiction. In "To the Lighthouse" they are part of the structure, but also part of the experience of life, how the flux of existence is perceived. This essay focuses not only on the ?little daily miracles? which replace a great revelation, but also on the nature of the chaos, the passing and flowin

Moving from theory to practice : Experience of implementing a learning supporting model designed to increase patient involvement and autonomy in care

Background: In implementing new programs of care, such as person-centered care, there is a risk that the focus will be at an organizational level, instead of a level that describes what happens in the personal development among staff. The aim of this study was to describe experiences of the implementation process of a learning supporting model designed to increase patient involvement and autonomy

Bioenergy and Land Use Change-State of the Art

The dedicated production of biomass crops and the collection of residues in agriculture and forestry can lead to undesirable negative impacts and it is crucial that practices are found that ensure that these impacts are avoided or mitigated as far as possible. This chapter concerns the use of biomass for energy and the connection between increased bioenergy use and land use change (LUC). Land use

Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairment

Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

Background: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. Methods: The study included 1

Protein Recovery Using Simulated Moving Bed Technology and Macroporous Chromatographic Support Material

Due to its gentle and high resolving power, chromatography is the work horse within protein separation. Still it is an expensive method due to low productivity, diluted product streams, large waste streams and expensive support material. This limits its potential use to areas of high price products. Therefore there is a clear interest to make the technology cheaper to use both for the existing pha

Complex human-nature system interactions in a resource constrained world - system analysis of problems associated to resource use and scarcity, and potential solutions aiming at resource efficiency

This paper provides a systemic analysis of complex dynamic issues associated with resource use, scarcity and efficiency by applying systems thinking with respect to sustainability criteria. Casual loop diagramming methodology is adopted to create a conceptual model to better understand the interconnected patterns, cause effect relations and feedbacks between the three dynamic complex systems that

Laccases from New Fungal Sources and Some Promising Applications

Fungi are a group of organisms with the ability to produce different types of enzymes in order to get access to nutrients. Among the enzymes, oxidoreductases have the ability to degrade lignocellulosic material via an oxidative mechanism, facilitating the uptake of cellulosic material, which will be metabolized using other enzymes to provide the required nutrients to the fungi. Ecologically, oxido

Characteristics and Outcomes of Patients Receiving a Second Rescue Valve During Transcatheter Aortic Valve Implantation

Background: Transcatheter aortic valve implantation (TAVI) has become a safe procedure. However, complications occur, including uncommon complications such as valve malposition, which requires the implantation of an additional rescue valve (rescue-AV). The aim was to study the occurrence and outcomes of rescue-AV in a nationwide registry. Methods: The Swedish national TAVI registry was used as the

Exploring the impact of age on the predictive power of the National Early Warning score (NEWS) 2, and long-term prognosis among patients reviewed by a Rapid Response Team : A prospective, multi-centre study

Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term

Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders

Background Robust clinical indices of etiologic heterogeneity for psychiatric disorders are rare. We investigate whether age at onset (AAO) reflects genetic heterogeneity, utilizing Genetic Risk Ratios (GRR) derived from Family Genetic Risk Scores (FGRS). Methods We examined, in individuals born in Sweden 1940-2003, whether AAO for five primary disorders - drug use disorder (DUD), alcohol use diso

All-cause and cause-specific mortality in respiratory symptom clusters : a population-based multicohort study

Background: Respiratory symptoms are common in the general adult population. Increased burden of respiratory symptoms may increase the risk of mortality. We assessed the association between respiratory symptom clusters and mortality. Methods: Participants were derived from two population-based Swedish adult cohorts (N = 63,060). Cluster analysis was performed with Locality Sensitive Hashing (LSH)-

Acute Kidney Injury After Abdominal Surgery : Incidence, Risk Factors, and Outcome

BACKGROUND: Acute kidney injury (AKI) is a serious complication after major surgical procedures. We examined the incidence, risk factors, and mortality of patients who sustained AKI after abdominal surgery in a large population-based cohort.METHODS: All patients who underwent open and laparoscopic abdominal surgery (excluding genitourinary and abdominal vascular procedures), between 2007 and 2014

A four-stage model of the co-evolution of hominin cooperation and communication

Language is a complex semiotic system based on the context-sensitive use of signs, in contrast to the comparatively rigid systems of signals used by other animals, making it a uniquely human bio-cultural adaptation. But equally unique for human beings are other semiotic systems, and their corresponding sociocultural practices, such as (representational) gesture, the use of pictures and music. Cruc

Comprehensive Ecological Functional Zoning : A Data-Driven Approach for Sustainable Land Use and Environmental Management—A Case Study in Shenzhen, China

A comprehensive approach to ecological functional zoning in the Shenzhen region of China is presented in this study. Through the integration of advanced geospatial analysis tools, multiple data sources, and sophisticated statistical techniques, different ecological functions have been identified and categorized based on a comprehensive set of indicators and spatial analysis techniques. The three-l