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Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroi
Eukaryotic cell cycles are controlled by the activities of cyclin-dependent kinases (cdks). The major cdk in budding yeast, Saccharomyces cerevisiae, is Cdc28p. Activation of Cdc28p requires phosphorylation on threonine 169 and binding to a cyclin. Thr-169 is phosphorylated by the cdk-activating kinase (CAK), Cak1p, which was recently identified as the physiological CAK in budding yeast. Here we p
Granulosa and theca cell tumors of the ovary account for 2-3% of ovarian malignancies. This study includes 54 patients with the diagnosis of granulosa cell tumors of the ovary treated between 1953 and 1987. Median age at diagnosis was 57 (27-83) years. The lesions were staged according to FIGO. The number of patients in various stages was IA, 41; IB, 3; IC, 3; IIB, 6; and III, 1. Median tumor size
A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal
The causes and extent of regional inequality in the process of economic growth are at the core of historical economic research. So far, much attention has been devoted to studying the role of industrialization in driving regional divergence. However, empirical studies on relatively unequal countries such as Italy and Spain show that inequality was already high at the outset of modern industrializa
PURPOSE: To develop a mapping model to estimate EQ-5D-3L from the Knee Injury and Osteoarthritis Outcome Score (KOOS).METHODS: The responses to EQ-5D-3L and KOOS questionnaires (n = 40,459 observations) were obtained from the Swedish National anterior cruciate ligament (ACL) Register for patients ≥ 18 years with the knee ACL injury. We used linear regression (LR) and beta-mixture (BM) for direct m
Introduction Sierra Leone has the world's highest maternal mortality, partly due to low access to caesarean section. Limited data are available to guide improvement. In this study, we aimed to analyse the rate and mortality of caesarean sections in the country. Methods We conducted a retrospective study of all caesarean sections and all reported in-facility maternal deaths in Sierra Leone in 2016.
This paper is based on a lecture held in Nagoya, Japan as part of a seminar on issues relating to disabled women, sexuality and sexual and reproductive health and rights (SRHR). I present preliminary results from the research project Sexual Citizenship and Disability: Implications for Theory, Practice and Policy, which focuses on sexual rights for people with mobility impairments. The data compris
This study examines the consequences of grade inflation at the upper secondary education level on enrolment in higher education and earnings for Sweden. Although grade inflation is unfair and may imply inefficient allocation of human resources, current knowledge of grade inflation effects on individual outcomes is scarce. One explanation is probably the challenge of measuring and estimating causal
This chapter discusses the changes in protein phosphorylation following ischemia, with particular reference to the regulation of the initiation of protein synthesis. Transient cerebral ischemia seems to induce a post-ischemic imbalance between protein kinase and protein phosphatase activities, leading to a net dephosphorylation of proteins in the vulnerable neurons. This imbalance may lead to the
Performing The Other. Report on workshops on observing and imitatingThe lecture will present the experience, results and challenges arising within a series of workshops that were investigating the role of observation, copying and imitation in the actor’s work, activities close to Brecht’s aesthetic focus. Claiming that “people will observe you, in order to investigate how well you have observed”,
The purpose of this report is to discuss how a decarbonising the steel, plastic, and paper industries may affect economic growth, wages and employment in the European Union (EU). We approach the issue from two different angles. First, we discuss how a decarbonization of the three industries may affect the rest of the economy. Second, we discuss how a decarbonization of the three industries may af
Purpose To examine the strategic focus of shippers and transport providers (TPs) in reducing the environmental impact of transportation. Research questions: 1) To what extent are the green practices related to transportation described in literature being realised in practice by shippers and TPs? 2) How do shippers and TPs prioritise transportation compared to other initiatives for greening the sup
“Garden phlox ‘Alma Jansson’ comes from a smallholding in Roslagen. It has been on the farm at least since 1939 when Stina Jansson moved in. It was her mother-in-law, Alma Jansson, who took care of the plants in the garden. ‘Everything comes from Grandma. She had such beautiful flowers’, said Stina. We do not know where she received or bought this variety, but it was not newly planted in 1939.” Th
