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Experimental autoimmune encephalomyelitis (EAE) shares similar immunological and clinical features with multiple sclerosis (MS), and is therefore widely used as a model to identify new drug targets for better patient treatment. MS is characterized by several different disease courses: relapsing-remitting MS (RRMS), primary progressive MS (PPMS), secondary progressive MS (SPMS), and a rare progress
Starting from Barry Buzan and Richard Little’s recent assertion in Millennium that ‘international relations has failed as an intellectual project’, I argue that if the study of international political theory is to learn anything from this failure, it is the need for a conversation that encourages heterologue. If such a conversation is to be of any value at all then it needs to escape the binary du
Extensive anti-government protests were held in Poland in October 2020 related to accumulated social tensions due to COVID-19 pandemic among others. We attempt a question of how understanding communication patterns among protesters could possibly support epidemiological harm reduction campaigns. To do so, we analysed tweets in Polish language with hashtags: #Strajkkobiet representing pro-choice mo
In recent years, school strikes and street protests for climate justice have drawn international attention to young people's mobilisation and activism on global issues. This article addresses the need to map the history of global awareness among young people by exploring the origins of the Operation Dagsverke (Operation Day's Work) campaign in Sweden during the early 1960s. Drawing primarily on ma
This study examines the extent of the gap between the proportions of survey respondents reporting (1) having the possibility to use and (2) using special transport services (STS) compared to the corresponding gaps for other transport modes. For persons eligible for STS, differences between those who use them and those who do not use them are explored. The frequencies with which these two groups le
There is a long history presuming smell is not expressible in language, but numerous studies in recent years challenge this presupposition. Large smell lexica have been reported around the world thereby showing high lexical codability in this domain. Psycholinguistic studies likewise find smell can be described with relatively high agreement, demonstrating high efficient codability. Often the two
Mental health problems affect the patients and their families, who may also need therapeutic interventions. Mindfulness interventions have shown beneficial health effects for clinical and healthy populations. A web-based mindfulness intervention was tailored to address families' needs of support and tested in a pilot intervention study. The aim of this study was to explore the participants' experi
Importance: Excess alcohol consumption and alcohol use disorders (AUDs) are associated with substantially increased mortality. Efforts to reduce this toll require an understanding of their causes. Objective: To clarify the degree to which the excess mortality associated with AUDs arises (1) from the predispositions of the person who develops AUD (and which would likely be shared by close relatives
We study a simple heteropolymer model containing sequence-independent local interactions on both square and triangular lattices. Sticking to a two-letter code, we investigate the model for varying strength κ of the local interactions; κ=0 corresponds to the well-known HP model [K. F. Lau and K. A. Dill, Macromolecules 22, 3986 (1989)]. By exhaustive enumerations for short chains, we obtain all str
I investigate the relation between institutions, markets, and preindustrial economic growth. In particular, I analyze the impact of coercive agricultural class structures on urban population growth in Poland. My main point is that the impact of the demesne economy based on serfdom on urban growth was neither inherently negative nor positive. Instead, I suggest that the effect of serfdom depended o
The Late Ordovician mass extinction (LOME) coincided with dramatic climate changes, but there are numerous ways in which these changes could have driven marine extinctions. We use a palaeobiogeographic database of rhynchonelliform brachiopods to examine the selectivity of Late Ordovician-Early Silurian genus extinctions and evaluate which extinction drivers are best supported by the data. The firs
'Heat' diarrhea in foals is an onerous but not life-threatening ailment, which indicates that it may be of osmotic origin. This was confirmed by a successful attempt, presented in this paper, to alleviate the severity and duration of foal heat diarrhea with the use of a typical absorbent, kaolin clay, as a feed additive, usually applied in feed production as an anticaking agent. Based on the prese
The mechanisms responsible for the transfer of energy and water within the climate system are under worldwide investigation within the framework of the Global Energy and Water Cycle Experiment (GEWEX) to improve the predictability of natural and man-made climate changes at short and long ranges and their impact on water resources. Five continental-scale experiments have been established within GEW
Human cystatin C, a member of the cysteine proteinaseinhibitory family, is produced by all nucleated cells and has important roles in regulating natural immunity. Nematode homologs to human cystatin C have been shown to have anti-inflammatory effects on monocytes and to reduce colitis in mice. In Crohn’s disease, pathogenic activated monocytes help drive inflammatory processes via the release of p
Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal
