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Some evidences suggest that obesity impairs the effectiveness of TNF inhibitors. We examined the impact of body mass index (BMI) on the clinical effectiveness of abatacept in rheumatoid arthritis (RA) patients. This is a pooled analysis of 10 prospective cohorts of RA patients. All patients with available BMI were included in this study. The primary endpoint was drug retention of abatacept in the
The present review reports on the influence of alcohol drinking and alcohol use disorders on psychiatric disorders and suicidal behaviour. The base of the study was previous reviews of the National Institute on Alcohol Abuse and Alcoholism publication Alcohol and Health in 1993 and by Helgason in 1996. Using a defined search strategy in Medline, another 42 articles from 1994 to 1996 were included
INTRODUCTION: Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) and bone microarchitecture in AS was conducted to compare peripheral vBMD in AS patients with that in healthy controls, to study vBMD in axial compared with peripheral bone, and
This article analyses the selection of person reference expressions in narratives in Umpila/Kuuku Ya'u, a Pama-Nyungan language of Cape York Peninsula (Australia). The analysis takes the principle of topic-fittedness, one of a set of design principles proposed to account for the interactional conditioning of person reference formulation, and applies it to Umpila/Kuuku Ya'u narration. The ensuing a
Although reports of pharmaceutical bioconcentration in aquatic organisms are increasing, less is known about trophic transfer in aquatic food webs. The bioaccumulation and trophodynamics of sertraline and fluoxetine, 2 selective serotonin reuptake inhibitors (SSRIs) frequently detected in aquatic environments, were tested by exposing constructed aquatic food chains to SSRIs under controlled labora
The expression of a variety of nuclear genes encoding mitochondrial proteins is known to adapt to changes in environmental conditions and retrograde signaling. The presence of putative WRKY transcription factor binding sites (W-boxes) in the promoters of many of these genes prompted a screen of 72 annotated WRKY factors in the Arabidopsis (Arabidopsis thaliana) genome for regulators of transcripts
Popular Abstract in Swedish Ta ett djupt andetag och tänk på vad du nu har i lungorna! Jo, det är luft, förstås, syre kväve och sådant. Men det är också något annat. I varje kubikcentimeter du andas in finns tusentals partiklar, alla för små för att kunna ses med blotta ögat. Om dessa partiklar handlar denna avhandling. Vi kallar luftburna partiklar för aerosoler, ett begrepp som innefattar allt Airborne particles are everywhere around us, and have always been. Particles generated by human activities has increased drastically since industrialization, and several epidemiological studies have shown that inhaled particles can cause adverse health effects. The concern about health effects have during the last decade shifted towards fine and ultrafine particles, not least due to the emerging f
Objectives: To examine the associations between food patterns constructed using cluster analysis and markers of systemic and vascular inflammation, and incident cardiovascular disease (CVD) after 13 years of follow-up. Design: Population-based, prospective cohort study. Setting and subjects: Cluster analysis identified six food patterns from 43 food group variables among 4999 subjects, aged 45-68
Popular Abstract in Swedish Delfiner och andra tandvalar har förmågan att ekolokalisera. Trots att dessa djur länge fascinerat människor genom historien var det först på 1950-talet som man lyckades bevisa att de faktiskt har denna förmåga. Det finns fortfarande många fundamentala frågor angående deras ekolokalisering som ännu inte besvarats, till stor del för att det har krävt alltför avancerad teToothed whales (Odontocetes) use echolocation to navigate and find food in dark or murky waters. A wide range of innovative studies has since the 1960:s been used to characterize their echolocation beam and map out their echolocation skills. In order to render high quality recordings of the sounds emitted by these animals, advanced measurement systems are required. There are still interesting en
TMJ autopsy specimens were studied macroscopically and arthrographically with respect to the disc position in the sagittal and the coronal planes. After single-contrast arthrography of the lower joint space, the specimens were cryosectioned. The arthrographic findings were correlated with the morphological findings. Anterior disc position was found in about two thirds and sideways disc displacemen
In a laboratory investigation using tunable picosecond lasers in a pump-probe configuration, lifetimes of the E (II)-I-1, v = O and v = 1 states of CO are experimentally determined. For E (II)-I-1, v = 1, the lifetime is found to vary significantly for the isotopomers. Combining the data with existing oscillator strengths, predissociation probabilities within the range of 93.6%-98.64% result for (
In this paper we establish a geometry-based stochastic ultra-wideband channel model for outdoor infostations scenarios. We statistically describe the location and strength of clusters of scatterers, as well as the shape and width of visibility and shadowing regions. We also separately model diffuse radiation (which cannot be explained by the scatterer components), and show that its fading statisti
Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard mo
This study investigates the influence on the realism of confidence judgments of four different factors, the individual, the knowledge domain (crystallized and fluid intelligence), gender and cognitive style (Need-for-Cognition, NfC). Seventy-nine high-school students answered questions on word knowledge (WORD) and logical/spatial ability (DTK), both tests were administered on three occasions with
