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In the present investigation, we sought to refine the classification of urothelial carcinoma by combining information on gene expression, genomic, and gene mutation levels. For these purposes, we performed gene expression analysis of 144 carcinomas, and whole genome array-CGH analysis and mutation analyses of FGFR3, PIK3CA, KRAS, HRAS, NRAS, TP53, CDKN2A, and TSC1 in 103 of these cases. Hierarchic
This paper outlines some reasons for why gestures are relevant to the study of SLA. First, given cross-cultural and cross-linguistic gestural repertoires, gestures can be treated as part of what learners can acquire in a target language. Gestures can therefore be studied as a developing system in their own right both in L2 production and comprehension. Second, because of the close link between ges
In this paper, the thermal impact of using different steel laminations in the stator and the rotor of a permanentmagnet assisted synchronous reluctance machine designed for an automotive application is studied. In this regard, two main parameters of the steel lamination materials, thickness and amount of alloy content in weight percent, are studied. Frequency characteristics of the iron losses of
An RH method was proposed in the late 1970s to replace the traditional CM-method in Sweden and from 1984 the RH-method is the dominating method to measure moisture in concrete floors before applying a moisture sensitive floor covering. The required total uncertainty must be smaller than 2-3 % RH depending on the method used. The paper describes the historical development of RH measurements in conc
We consider a multiple input multiple output (MIMO) system wherein channel correlation as well as noisy channel estimation are both taken into account. For a given block fading duration, pilot-assisted channel estimation is carried out with the aid of a minimum mean square error estimator. The pilot sequences and data are jointly optimized to maximize the ergodic capacity while fulfilling a total
Using exact dispersion relations for electromagnetic wave propagation in layered, periodic media, consisting of two phases, we derive explicit asymptotic solutions for small wavenumbers. These solutions are compared to the numerical solutions of the exact dispersion relations, and applications to homogenization problems are discussed. The results can be used as test cases for homogenization techni
Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell frag
In order to maximize their fitness, individuals aim at choosing territories offering the most appropriate combination of resources. As population size fluctuates in time, the frequency of breeding territory occupancy reflects territory quality. We investigated the relationships between the frequency of territory occupancy (2002-2009) vs. habitat characteristics, prey abundance, reproductive succes
Scientific performance is often evaluated by bibliometric indicators such as publication counts or citations. But this may neglect other relevant outputs from research units. An optimal evaluation would measure each dimension separately, but this would be costly. Luckily, cluster analyses show that units which specialise in other types of research activities (such as knowledge transfer or educatio
Nontypeable Haemophilus influenzae (NTHI) is a leading cause of opportunistic infections of the respiratory tract in children and adults. Although considered an extracellular pathogen, NTHI has been observed repeatedly within and between cells of the human respiratory tract, and these observations have been correlated to symptomatic infection. These findings are intriguing in light of the knowledg
Deoxyribonucleoside kinases (dNKs) are essential in the mammalian cell but their 'importance' in bacteria, especially aquatic ones, is less clear. We studied two aquatic bacteria, Gram-negative Flavobacterium psychrophilum JIP02/86 and Polaribacter sp. MED152, for their ability to salvage deoxyribonucleosides (dNs). Both had a Gram-positive-type thymidine kinase (TK1), which could phosphorylate th
