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MZB Cell Development and Function

Marginal zone B cells (MZB cells) are innate like B cells that are predominantly located alongside memory B cells in the microanatomical region of the spleen of humans and mice termed the marginal zone. They circulate in humans but not mice, and in humans can be identified in blood and other lymphoid tissues, including the gut-associated lymphoid tissue, where they, as in spleen, form a zone surro

High sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of preeclampsia following assisted reproduction treatment

OBJECTIVE: To study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment.DESIGN: A prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding pre

T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation

Recently, we reported that CD40-/- mice, exhibiting exclusively T cell-independent IgA class switch recombination (CSR), demonstrated near normal levels of IgA plasma cells in the gut lamina propria (LP), despite the complete lack of germinal centers (GCs). In this study, we have extended our analysis focusing on how to reconcile these findings using flow cytometry and molecular markers for IgA CS

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibro-blast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism involving this serpin-protease system in the developing neural crest (NC). Knockdown of SerpinE2 by injected antisense morpholino oligonucleotides did

Short-term aid or long-term gains? : Harnessing Sudan's humanitarian response for the resilience of its health system

The Sudan 2023 Humanitarian Response Plan was revised in May, 2023, due to the escalating violence in the country. This revision increased the scale of assistance and protection activities and suspended the funding allocated for access to livelihood, access to basic services, and for the implementation of resilience solutions. We call to rethink Sudan's current humanitarian response through a pro-

Islamic “interest-free” bonds-how Islamic are they?

The Islamic financial sector has developed its instruments rapidly since the 1960s, and a Muslim customer can get almost all financial services supplied by the conventional Western type of financial sector through so-called participation banks, which are run, it is said, in compliance with Islamic values and norms. For instance, they collect funds by special methods to finance economic activities,

L1-orienterad grammatikundervisning i L2-kontext : En kvalitativ studie

Artikeln beskriver hur en grammatikdidaktisk modell utformad för en L1-kontext kan användas för grammatikundervisning såväl som för ett språk- och skrivutvecklande arbete i en L2-kontext. Eftersom klassrummen i Sverige, Danmark och Norge allt mer blir språkligt heterogena behöver lärare kunna erbjuda en språkutvecklande under-visning för elever med skilda språkliga förutsättningar. Den modell som The article shows how a grammar-didactic model designed for an L1 context can be used for grammar learning as well as language and writing development in an L2 con-text. Because classrooms in Sweden, Denmark and Norway are becoming increasingly heterogenous, teachers must be able to develop the language of pupils with differing linguistic predispositions. The model that is being proposed is design

The Politics of the Beast : Rewiring Revelation 17

Revelation’s Whore of Babylon and the hybrid animal upon which she rides provide a female-beastly assemblage against which is constructed the good sovereignty of the Lamb. Derrida’s thinking of animality and sovereignty indicates how the human political realm carves out its sovereign position in relation to the category “animal” and in reliance on a “reason of the strongest.” It is demonstrated th

A method to find the optimum routes and stations for Bus Rapid Transit in urban areas

Public transportation (PT) is an essential system for cities to achieve sustainability. However, determination of proper locations for PT stations and finding suitable routes are critical decisions. This paper aims to propose a novel method to determine BRT stations and routes in the cities, using Fuzzy Inference System (FIS) and Binary Integer Programming (BIP). In the proposed method, first, a s

Women´s experiences of preeclampsia as a condition of uncertainty : a qualitative study

BACKGROUND: Preeclampsia is a severe condition that annually affects about 3-8% of pregnancies worldwide. Preeclampsia is thereby one of the most common pregnancy complications for both mother and child. Despite that, there is limited research exploring the women´s perspective of experiencing preeclampsia.AIM: The aim of this study was to describe women´s experiences of preeclampsia to improve the