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Febrile Urinary Tract Infection: P fimbriae, Innate Host Response and Bacteremia

Popular Abstract in Swedish Urinvägsinfektioner (UVI) är en av människans vanligaste bakteriella infektioner och drabbar både kvinnor och män. Kvinnor drabbas av UVI under hela sitt vuxna liv, medan UVI incidensen hos män ökar efter 40 – 50 års ålder pga. ökande problematik i urinvägarna med prostataförstoring, m.m. UVI orsakas av ett flertal olika bakteriearter, men tarmbakterien Escherichia coliUrinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). P fimbriae are the virulence factor of E. coli most clearly associated to severe disease. P fimbriated E. coli predominated in bacteremic febrile UT

Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.

Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE). Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detecte

Electron transfer from the singlet and triplet excited states of Ru(dcbpy)(2)(NCS)(2) into nanocrystalline TiO2 thin films

Time-resolved absorption spectroscopy was used to study the femtosecond and picosecond time scale electron injection from the excited singlet and triplet states of Ru(dcbpY)(2)(NCS)(2) (RuN3) into titanium dioxide (TiO2) nanocrystalline particle film in acetonitrile. The fastest resolved time constant of similar to30 fs was shown to reflect a sum of two parallel ultrafast processes, nonergodic ele

The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Germ layer formation and primary axis development rely on Fibroblast growth factors (FGFs). In Xenopus, the secreted serine protease HtrA1 induces mesoderm and posterior trunk/tail structures by facilitating the spread of FGF signals. Here, we show that the serpin Protease nexin-1 (PN1) is transcriptionally activated by FGF signals, suppresses mesoderm and promotes head development in mRNA-injecte

A new type of long gamma-ray burst

We consider gamma-ray bursts (GRBs) produced by the merger of a massive white dwarf with a neutron star. We show that these are likely to produce long-duration GRBs, in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation, and occur close to the host galaxy. However, rare members of the class need not

Measurements of optical properties of pig brain tissue in vitro using a novel compact device

In numerous medical and scientific fields, knowledge of the optical properties of tissues can be applied. Among many different ways of determining the optical properties of turbid media; integrating sphere measurements are widely used. However, this technique is associated with bulky equipment, complicated measuring techniques, interference compensation techniques, and inconvenient sample handling

Rotational CARS for simultaneous measurements of temperature and concentrations of N-2, O-2, CO, and CO2 demonstrated in a CO/air diffusion flame

Rotational coherent anti-Stokes Raman spectroscopy (CARS) has over the years demonstrated its strong potential to measure temperature and relative concentrations of major species in combustion. A recent work is the development and experimental validation of a CO2 model for thermometry, in addition to our previous rotational CARS models for other molecules. In the,present work, additional calibrati

Ultrafast formation of a carotenoid radical in LH2 antenna complexes of purple bacteria

The SI-mediated carotenoid to BChl a energy-transfer pathway and carotenoid radical formation have been studied using femtosecond time-resolved transient absorption spectroscopy. A series of LH2 complexes (LH2 = light-harvesting complex 2) from Rhodobacter sphaeroides incorporating carotenoids neurosporene, spheroidene, and spheroidenone were used to explore the effect of conjugation length. The S

Exploring the Railway System from a Risk Governance Perspective

Popular Abstract in Swedish Olyckor i järnvägssektorn kan ge upphov till katastrofala konsekvenser. I första hand kan människors liv och hälsa drabbas, men allvarliga konsekvenser kan även uppstå för samhället i stort. Detta beror på att järnvägssystemet, liksom en rad andra infrastruktursystem är väsentliga för att vårt moderna samhälle ska fungera. Under de senaste decennierna har dessa system bIn recent decades, the Swedish railway system has faced substantial deregulations. As a result, management of risk is often carried out in settings involving multiple stakeholders having various roles, mandates, and viewpoints on risk, and where no single stakeholder has the superior authority. In order to manage risks in this type of multi-actor setting, the traditional elements of risk assessmen

Cardiovascular Risk, Cardiac Function, Physical Activity, and Quality of Life with and without Long-Term Growth Hormone Therapy in Adult Survivors of Childhood Acute Lymphoblastic Leukemia.

Context: Long-term data are missing in GH-treated acute lymphoblastic leukemia (ALL) patients. GH therapy may result in poorer outcome regarding cardiovascular (CV) and particularly cardiac effects than in patients with hypothalamic-pituitary disease. Objective: Our objective was to evaluate GH therapy on CV risk, cardiac function, physical activity, and quality of life in ALL patients treated wit

IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection.

IgG antibodies against Clostridium difficile toxins A and B were followed in controls and patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that

The mania of the time. Falconry and bird brooches at Uppåkra and beyond

Bird brooches at Uppåkra have a changing biography, as grave gifts, pendants, and scrap metal. The association between bird brooches and birds of prey, and a male face to female jewellery opens questions of identy of the wearer and the male person in question. Following the bird brooches and the connotations of falconry decode both a social identiy and a lifestyle, expressed in the aestetics of th

Evaluation and testing in creativity

In situations that require creative thinking, there is no well-known procedure for how to reach the goal, or the solution. Among other things, it is not clear how choices between outcomes are made, or when the search for a solution should terminate. The article focusses on the evaluation of solutions that are generated during the search. The general question concerns the standards according to whi

Musical marginalization processes: Problematizing the marginalization concept through an example from early 20th century American popular culture.

The author sets out to analyse a number of representations of the biblical Hagar figure in African American and white American culture. Spivak (1988) has problematized the marginalization concept with regard to the study of the third world subject, arguing that knowledge always expresses the interests of the knowledge producers, and that Western academic research is always colonial. The aim of the

Molecularly imprinted polymers

Molecularly imprinted polymers (MIPs) are man-made polymeric materials with molecular recognition abilities. The polymers mimic the molecular recognition of natural molecular recognition elements, such as receptors and antibodies, by binding target molecules in a highly selective manner. The interactions between MIPs and their targets are of non-covalent or covalent nature, or a mixture thereof. F