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Den sjungande trappuppgången : Essä

Den sjungande trappuppgången är en TV-serie i sex avsnitt på SVT med start 6 februari 2012. Med inspiration från engelsk förlaga handlar serien om experimentet, att samla en större grupp människor med olika ålder och bakgrund, boende i samma förortsstadsdel utan större kontakt med sina grannar, och tillsammans bilda en sångkör med målet att uppträda vid offentliga konserter.

How European primary care practitioners think the timeliness of cancer diagnosis can be improved : a thematic analysis

BACKGROUND: National European cancer survival rates vary widely. Prolonged diagnostic intervals are thought to be a key factor in explaining these variations. Primary care practitioners (PCPs) frequently play a crucial role during initial cancer diagnosis; their knowledge could be used to improve the planning of more effective approaches to earlier cancer diagnosis. OBJECTIVES: This study sought t

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable

Vascular function in the cadaver up to six hours after cardiac arrest

BACKGROUND: The aim of the study was to evaluate how well vascular function is retained in a cadaver kept in a room with a temperature of 21 degrees C. METHODS: The aorta and pulmonary artery of rats were investigated in organ baths as fresh controls and after 1, 2, 3, or 6 hours' storage in the cadaver. Six-hour-old cadaver aortas were transplanted and investigated after 24 hours and 60 days. RES

A New Method to Make 2-D Wear Measurements Less Sensitive to Projection Differences of Cemented THAs

Wear curves from individual patients often show unexplained irregular wear curves or impossible values (negative wear). We postulated errors of two-dimensional wear measurements are mainly the result of radiographic projection differences. We tested a new method that makes two-dimensional wear measurements less sensitive for radiograph projection differences of cemented THAs. The measurement error

A subset of dendritic cells express joining chain (J-chain) protein

Joining chain (J-chain) is well known as an integrated component of dimeric immunoglobulin A (IgA) and pentameric IgM. We show here that the J-chain protein is also expressed in a subset of CD11c+ dendritic cells (DC) in C57BL/6 mice. J-chain knockout mice (J−/− mice) had a reduced fraction of CD4−/CD8α+ and mPDCA-1+ DC in the spleen. J−/− mice also had reduced levels of RNA for the immunoregulato

T-cell recognition of lipid peroxidation products breaks tolerance to self proteins

Peroxidation of polyunsaturated fatty acids in lipoproteins and cell membrane phospholipids occurs in many situations in the body, both under normal and pathological conditions. Low-density lipoprotein is particularly prone to oxidation and is believed to be a pathogenetic component in atherogenesis. Both antibody responses and T-cell responses to oxidatively modified lipoproteins have been demons

Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme

Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas, due to a critical role of N-cadherin in dorsal pancreatic mesenchymal cell survival. Here, we show that restoring cardiac and circulatory function in N-cadherin null mice by cardiac-specific ex

Presens och preteritum i skönlitterär prosa

I skönlitterär prosa förekommer det strängt taget enbart tre olika temporala texttyper: narration (berättande text, relation), citat (alltså dialog) och berättarens nutid (dvs. passager där en berättare talar i egen sak), och det finns bara två finita tempus att välja emellan: presens och preteritum. Det kan tyckas som om de skönlitterära författarna har ett snävt spelrum att operera inom. Men det