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Vascular function in the cadaver up to six hours after cardiac arrest

BACKGROUND: The aim of the study was to evaluate how well vascular function is retained in a cadaver kept in a room with a temperature of 21 degrees C. METHODS: The aorta and pulmonary artery of rats were investigated in organ baths as fresh controls and after 1, 2, 3, or 6 hours' storage in the cadaver. Six-hour-old cadaver aortas were transplanted and investigated after 24 hours and 60 days. RES

A New Method to Make 2-D Wear Measurements Less Sensitive to Projection Differences of Cemented THAs

Wear curves from individual patients often show unexplained irregular wear curves or impossible values (negative wear). We postulated errors of two-dimensional wear measurements are mainly the result of radiographic projection differences. We tested a new method that makes two-dimensional wear measurements less sensitive for radiograph projection differences of cemented THAs. The measurement error

A subset of dendritic cells express joining chain (J-chain) protein

Joining chain (J-chain) is well known as an integrated component of dimeric immunoglobulin A (IgA) and pentameric IgM. We show here that the J-chain protein is also expressed in a subset of CD11c+ dendritic cells (DC) in C57BL/6 mice. J-chain knockout mice (J−/− mice) had a reduced fraction of CD4−/CD8α+ and mPDCA-1+ DC in the spleen. J−/− mice also had reduced levels of RNA for the immunoregulato

T-cell recognition of lipid peroxidation products breaks tolerance to self proteins

Peroxidation of polyunsaturated fatty acids in lipoproteins and cell membrane phospholipids occurs in many situations in the body, both under normal and pathological conditions. Low-density lipoprotein is particularly prone to oxidation and is believed to be a pathogenetic component in atherogenesis. Both antibody responses and T-cell responses to oxidatively modified lipoproteins have been demons

Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme

Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas, due to a critical role of N-cadherin in dorsal pancreatic mesenchymal cell survival. Here, we show that restoring cardiac and circulatory function in N-cadherin null mice by cardiac-specific ex

Between the Highway and the Red Dirt Track : Subaltern Urbanization and Census Towns in India

In the 2011 census of India, more than 2500 settlements have been newly inducted into the category of ‘census towns’ – the lowest size-class of urban settlements in India. This is a staggering figure in light of the observation that a comparable number constituted the total number of all urban settlements recorded since 1900. Furthermore, it has been revealed through aerial images, that a vast maj

Endoplasmic reticulum stress regulation in hematopoietic stem cells

Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what