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Altering the Focus from the Ostensible Object and Purpose of the Treaty on the Prohibition of Nuclear Weapons to Collateral Treaty Effects of Strategic Nature : International Law Comments on the Impact of the Treaty’s Prohibitions of Assistance and Development on Technology, Research and Defence-Industry Policies of States in Exposed Geostrategic Locations: The Case of Sweden

This chapter aims to discuss the phenomenon of altering the telos of a treaty by changing the focus of its object and purpose through treaty implementation. To examine the consequences in international law of altering the telos of a treaty, this contribution uses the example of the 2017 Treaty on the Prohibition of Nuclear Weapons (TPNW) against the backdrop of the considerations regarding a possi

Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease

BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,

EPR in a non-OECD Context: An introduction to research projects on the management of WEEE

There has been an upsurge of interest in the principle of extended producer responsibility (EPR) among policy makers and scholars in non-OECD countries. The principle has been applied and its impacts studied rather extensively in various OECD countries. However, similar experiences are largely lacking in non-OECD countries. This paper presents some ongoing research and preliminary findings on the

Methods for understanding the mobile user experience

Evaluating the user experience is often done in a laboratory. Methods for observing what happens in the wild are nonetheless being employed because they bring results that the traditional methods of evaluation do not yield. In this paper we describe and discuss methods used at our lab for understanding the mobile user experience. These methods range from quantitative to qualitative evaluation, and

T-cell commitment inheritance—an agent-based multi-scale model

T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected and the necessary steps like programmed shut off of progenitor genes and T-cell genes upregulation have been revealed. However, the exact timing between decisio

SELF-PERCEIVED VOCAL HEALTH AND SOCIAL PARTICIPATION AMONG OLDER ADULTS

The aim of this study is to investigate the association between self-perceived voice problems and social participation among older adults (65-80 years). A complementary aim was to investigate the association between self-perceived voice problems and physical activity. Method Participants were recruited through social media and asked to complete an online questionnaire. In total, 152 individuals we

Social movement, collective behavior and constituent power

This paper mainly consists of two parts. The first one, originally written as an outline for the theoretical grounds of my thesis (that considers “the global justice movement”), consists in a discussion about the roots of the concept of social movements, and ends up in proposing three ways of conceiving social movements. The second part consists in an outline of one of these dimensions of social m

Att granska och diskutera. Epikanalyser

Vi lärare på Litteraturvetenskapliga institutionen vid Lunds universitet har länge saknat ett arbetsmaterial när vi undervisat i hur man utför epikanalyser. Det har visat sig att Claes-Göran Holmbergs och Anders Ohlssons Epikanalys. En introduktion har fungerat utmärkt som lärobok och på ett enkelt sätt utrett de många teorier och metoder som kan utnyttjas i en analys. Men våra erfarenheter av epi

Human papillomaviruses of skin and genital lesions

Popular Abstract in Swedish Omkring 16% av alla cancerfall i världen beräknas vara orsakade av infektioner och omkring 5% av dessa orsakas av humant papillomvirus (HPV). HPV har etablerats som orsak till livmoderhalscancer och kondylom (könsvårtor). HPV-typer som förekommer på hud har förknippats med icke-melanom hudcancer såsom skivepitelcancer (SCC) men också ofarliga hudhudförändringar som aktiAround 5% of all cancer cases worldwide are caused by human papillomavirus (HPV) which has been established as the cause of cervical cancer and genital warts (condylomas). Cutaneous HPV types have been weakly associated with non-melanoma skin lesions such as squamous cell carcinoma (SCC) and actinic keratosis (AK). We have analyzed skin and genital lesions for presence of HPV-DNA in order to searc

Bound to be Modern : Publishers' Cloth Bindings and the Material Culture of the Book, 1840–1914

Bound to Be Modern is the most comprehensive study to date on the emergence and function of publishers' cloth bindings. It brings together issues of aesthetics, technique, economy, and social change in order to explain why publishers in the 19th century began to have their books bound, and why decorated clothbindings were so successful as the Western world transitioned into modernity. This study

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy

Geography and geometry of pre-Caledonian western Baltica: U-Pb geochronology and Palaeomagnetism

Popular Abstract in Swedish Den kontinent Skandinavien idag tillhör kallas Eurasia, men den kontinent vi ser idag har inte alltid funnits. Kontinenterna var inte bara sammanfogade på andra sätt, de har också rört sig över jordens yta (de långsamma med samma hastighet som naglar växer!), i platt-tektoniska processer. Innan uppkomsten av Eurasia har Skandinavien i omgångar tillhört andra konstellatiIn an attempt to reconstruct the pre-Caledonian cratonic margin of Fennoscandia, U-Pb geochronological and geochemical investigations have been performed on allochthonous orthogneisses in the northern Swedish Caledonides. The crystalline basement of the nappes have also been examined to further constrain the continuation of various chronologically defined orogenic belts. To constrain the global pa

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Abstract in Uncoded languages El presente trabajo describe el proceso participativo vinculado al desarrollo y la implementación del prototipo de un modelo que tiene como principal objetivo servir de soporte durante el procesos de Evaluación Integrada de la Sostenibilidad (EIS) de diferentes opciones políticas de gestión de los recursos hídricos a diferentes niveles de acción. El modelo – llamado e

On-demand mapping and integration of thematic data

Cartographic mashup is a powerful tool for users to visualize thematic data together with base maps, and it is increasingly popular due to the better availability of geodata. In current typical mashups, thematic data and base mapscome from different providers without any connection between the data sets, and their scales are not synchronized. In this paper, we firstly explore the problems in such

Three perspectives on learning in a simulated patient scenario : a qualitative interview study with student, simulated patient, and teacher

INTRODUCTION: Patient simulation can be useful for medical students in developing communication skills for vulnerable situations. Three participants are primarily involved in the patient simulation activities: the student, the simulated patient (SP), and the teacher. We here aimed to explore these participants' perceptions of learning in a patient simulation scenario.METHODS: We conducted individu