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Den ökade digitaliseringen av ekonomin har medfört betydande utmaningar för traditionella skattesystem, särskilt i fråga om beskattning av multinationella företag med omfattande digital närvaro men utan fysisk etablering. Detta har lett till rättvisa konkurrensförhållanden mellan den digitala och den traditionella marknaden samt mellan olika staters skattebaser. Mot denna bakgrund har digital beskThe increasing digitalisation of the economy has led to significant challenges to traditional tax systems, particularly with regard to the taxation of multinational enterprises with substantial digital presence but no physical establishment. This has led to unequal competitive conditions between the digital and traditional markets, as well as between different states’ tax bases. Against this backg

The Journal of Clinical Investigation R e s e a R c h a R t i c l e 1jci.org Introduction Upon inflammation, an array of brain-mediated responses occurs. They are collectively referred to as the sickness syndrome and include fever, decreased food intake, inactivity, social withdrawal, and corticosteroid secretion (1, 2). These objective symptoms are accompanied by feelings of malaise and discomfor

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_journal_of_clinical_investigation.pdf - 2026-05-30

The very concept of human rights implies governmental accountability. To ensure that governments are indeed held accountable for their treatment of citizens and others the United Nations has established a wide range of mechanisms to monitor compliance, and to seek to prevent as well as respond to violations.These essays critically examine the functions, procedures, and performance of each of the m

OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

This study presents how sequential infiltration synthesis of trimethyl aluminium and water into a carbohydrate-based block copolymer was used to enable pattern transfer of 6 nm half-pitch horizontal cylinders into silicon. Specular neutron reflectometry measurements of poly(styrene)-block-maltoheptaose self-assembled into horizontal cylinders indicate an increasing content of alumina after each se

Preliminary mobile was considered to be a device to make human connections easier. But today the consumption of this device has been evolved to a platform for gaming, web surfing and GPS-enabled application capabilities. Embedding GPS in handheld devices, altered them to significant trajectory data gathering facilities. Raw GPS trajectory data is a series of points which contains hidden informatio

Barbiturates enhance the binding of [3H]diazepam to benzodiazepine receptor sites in rat brain. This effect occurs at pharmacologically relevant concentrations of barbiturates, and the relative activity of a series of compounds correlates highly with anesthetic activity of the barbiturates and with their ability to enhance postsynaptic inhibitory responses to the neurotransmitter γ-aminobutyric ac

Clean gas turbine combustion research has gained popularity in power generation and propulsion industry in recent days. Present days, advanced efficient emission (NOx, CO and UHC) reduction combustion technologies are acknowledged for using the lean premixed combustion system. To support continuous development of eco-friendly combustion system, a 4th generation dry low NOx prototype downscaled bur

The influences of operating conditions and physical properties of the two phases on the hydrodynamics and mass transfer in a circular liquid-liquid microchannel have been investigated. The polytetrafluoroethylene (PTFE) microchannel has an internal diameter of 0.7 mm and a T-shaped mixing junction. Sodium hydroxide solution was used as the aqueous phase. N-hexane and toluene were employed as the o

The aim of the present study was to determine the pollution load originating from storm water on Lake Vaxjosjon. Each year about 1,050,000 m3 of storm water are discharged into the lake. Storm water represents a substantial pollution source for the lake and therefore also a main reason for the hypertrophic conditions in the lake. In order to evaluate the effects of the discharged storm water on th