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Thioureido N-acetyllactosamine derivatives as potent galectin-7 and 9N inhibitors

Derivatives of N-acetyllactosamine carrying structurally diverse thioureido groups at galactose C3 were prepared from a C3'-azido N-acetyllactosamine derivative in a three-step reaction sequence involving azide reduction and isothiocyanate formation by thiophosgene treatment of the C3-amine, followed by reaction of the isothiocyanate with a panel of amines. Evaluation of the N-acetyllactosamine th

Foraging and the history of languages in the Malay Peninsula

The hunter-gatherer groups of Southeast Asia represent a diverse range of adaptations. The so-called Negritos of the Andaman Islands, the Malay Peninsula and the Philippines have attracted particular attention because of long-standing claims that they represent traces of pre-agricultural Southeast Asia. Research on Andaman and Philippine prehistory has tended to maintain at least some components o

Competence as a prerequisite for the attainment of life quality

This paper describes differences between the capacity of Swedish and Danish students to attain life quality. This was carried out by examining the level of competence in four different groups of Swedish and Danish students, and is based on the hypothesis that the possession of competence is a premise for the development of life quality. Competence means the ability to make sense in complex situati

The mimesis hierarchy of semiotic development: five stages of intersubjectivity in children

The paper proposes that intersubjectivity develops in children along a progression of five (more or less) distinct stages of semiotic development. The theoretical model within which this is couched is the Mimesis Hierarchy (MH) model (Zlatev & Andrén 2009). As in previous treatments, the MH-model focuses on bodily mimesis, its “precursors” (empathetic perception) and “post-developments” (conve

Cerium as a quantum state probe for rare-earth qubits in a crystal

Popular Abstract in Swedish En indikator-jon för en kvantdator Ända sedan transistorn uppfanns 1948 har datorer blivit allt mer kraftfulla. Trots den enorma utveckling som skett finns det fortfarande problem som är för svåra för en dator att lösa. Ett exempel är simulering av stora molekyler, t.ex. proteiner, vilket skulle vara användbart inom medicin och biologi, bland annat för att förutsäga hRare-earth ions doped into a transparent crystal can have optically excited states with coherence times of milliseconds and hyperfine levels with coherence times of hours when cooled down to liquid helium temperatures. This makes them attractive for developing quantum computing hardware. A quantum transistor can be implemented in a rare-earth-ion-doped crystal by utilizing a dipole blockade effe

Genetic control of the variable innate immune response to asymptomatic bacteriuria.

The severity of urinary tract infection (UTI) reflects the quality and magnitude of the host response. While strong local and systemic innate immune activation occurs in patients with acute pyelonephritis, the response to asymptomatic bacteriuria (ABU) is low. The immune response repertoire in ABU has not been characterized, due to the inherent problem to distinguish bacterial differences from hos

Microfluidic separation of parasites and parasite-infected cells from blood for the diagnosis of leishmaniasis

Microfluidic techniques were applied to the separation of parasite and parasite-infected cells from blood to facilitate the detection of leishmaniasis, a disease representing a high burden in the developing world and for which new diagnostic tools are urgently needed. Leishmania mexicana promastigotes were successfully separated from red blood cells in a deterministic lateral displacement device.

Mapping critical loads for nitrogen based on biodiversity using ForSAFE-VEG: introducing the basic principles

This chapter describes the basic principles inside the VEG extension to the ForSAFE model system. It allows changes in ground vegetation to be calculated, an important part of biodiversity. In the VEG model, the basis for modelling ground vegetation dynamics is a competition strength model based on soil chemistry promoting and retarding factors, nutrients, water and light. The strength is used in

A Kind of Friend (text)

The text "A Kind of Friend" is a written abstract about the video essay with the sam name