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Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all
The standard of care is a legal and professional notion against which doctors and other medical personnel are held liable. The standard of care changes as new scientific findings and technological innovations within medicine, pharmacology, nursing and public health are developed and adopted. This study consists of four parts. Part 1 describes the problem and gives concrete examples of its occurren
Aberrant expression of miR-96 in prostate cancer has previously been reported. However, the role and mechanism of action of miR-96 in prostate cancer has not been determined. In this study, the diagnostic and prognostic properties of miR-96 expression levels were investigated by qRT-PCR in two well documented prostate cancer cohorts. The miR-96 expression was found to be significantly higher in pr
It is argued that the Achilles heel of contemporary sociology – and great parts of social science – is a) weak theory development, and b) absence of a meta-theory providing a common platform and a shared goal for its practitioners, fostering cumulativity. A meta-theory called causal realism (a variant of critical realism) is suggested for these purposes. The main tenets and key concepts of realism
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, wh
Popular Abstract in Swedish Under den senaste tiden har problematiken med klimatförändringarna debatterats livligt. För att kunna förutspå den framtida omfattningen av klimatförändringarna och vilka konsekvenser dessa kommer att ha är det ytterst relevant att känna till utbytet av växthusgaser mellan atmosfär och jordens alla ekosystem. Arktiska ekosystem är ytterst känsliga för den globala uppvärArctic ecosystems play a key role in the terrestrial carbon (C) cycle, but spa-tially explicit data on the C exchange is scarce in these remote areas. The global warming is especially dominant in the Arctic, and these areas are vul-nerable to climate change. It is therefore important to quantify and understand the processes affecting the C dynamics in these regions. In this thesis, the land-atmosp
In 2010, unmet medical care and sexual health counseling needs were assessed among students at a Ugandan University. Unmet medical care need was associated with poor mental health, experience of sexual coercion, and poor self-rated health. Unmet sexual health counseling need was significantly associated with being female, coming from an urban area, low social participation, poor mental health stat
Efter införande av Hälsoval Skåne har andelen av befolkningen som besökt allmänläkare ökat, liksom antalet besök per invånare. Ökningarna är överlag måttliga, med undantag för äldre män med lägre inkomst, där ökningen är större.Det finns också en minskning av besöken till övriga specialistläkare så att det totala antalet läkarbesök per invånare minskat i vissa grupper. Färre besök hos övriga speci
Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to low vitamin D levels. Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-
Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which results in overtreatment for many patients, and for others, leads to death from recurrent disease. Therefore, additional criteria are needed to better personalize care and maximize treatment effectiveness and survival.
Inom den europeiska politiken har det på senare år växt fram fler främlingsfientliga element. Många av dessa lägger tyngd på islam och muslimska kulturer som ett hot mot den europeiska välfärden och nationell identitet. British National Party är ett exempel på ett parti som sätter nationalism i första led och som är uppenbart främlingsfientliga. De lägger stor tyngd på att framställa islam och mus
Titel: Keeping up with narcissism: en studie om narcissism i ”Keeping up with the Kardashians” Författare: Linnett Andersen MKVA22:4: Medie- och kommunikationsvetenskap vid institutionen för kommunikation och medier, Lunds Universitet Enligt Twenge & Campbell (2009) är media och kändisar ”superspreaders” av narcissism genom bland annat reality-tv, och i en studie utförd av Young & Pins
Preeclampsia (PE) is a serious pregnancy complication that manifests as hypertension and proteinuria after the 20(th) gestation week. Previously, fetal hemoglobin (HbF) has been identified as a plausible causative factor. Cell-free Hb and its degradation products are known to cause oxidative stress and tissue damage, typical of the PE placenta. A1M (α1-microglobulin) is an endogenous scavenger of
A flattening filter free x-ray beam mode was added to an Elekta linear accelerator by placing a flat copper plate in the filter carousel and recalibrating the electron steering servo, gun servo and dosimetry system. Machine configurations were saved onto a separate hard disk in order to remain separate from the clinical configuration. Profile measurements with a Schuster BMS diode array show that
Background: Prostate-specific antigen (PSA) has modest specificity for prostate cancer. A panel of four kallikrein markers (total PSA, free PSA, intact PSA, and kallikrein-related peptidase 2) is a highly accurate predictor of biopsy outcome. The clinical significance of biopsy-detectable cancers in men classified as low-risk by this panel remains unclear. Methods: The Malmo Diet and Cancer study
Key points Chemokine (C-C motif) ligand 28 (CCL28) is a novel growth factor for human hematopoietic stem- and progenitor cells.CCL28 supports the in vitro and in vivo functional integrity of cultured primitive hematopoietic cells.
Introduction: Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. While the specific role of PMN in systemic lupus erythematosus (SLE) and autoimmunity is still unclear, their importance in chronic inflammation is gaining more attention. Here we investigate aspects of function, bone marrow release and activation of PMN in patients with SLE. Methods: The followi
