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Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells
The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML). Mechanisms behind expression of WT1, as well as consequences thereof, are still unclear. Here, we report that the fusion protein BCR/ABL1 increases expression of WT1 mRNA and protein via the phosphatidylinositol-3
Prehospital fast track care for patients with hip fracture: Impact on time to surgery, hospital stay, post-operative complications and mortality a randomised, controlled trial.
Ambulance organisations in Sweden have introduced prehospital fast track care (PFTC) for patients with suspected hip fracture. This means that the ambulance nurse starts the pre-operative procedure otherwise implemented at the accident & emergency ward (A&E) and transports the patient directly to the radiology department instead of A&E. If the diagnosis is confirmed, the patient is tra
A Cost Effectiveness Analysis Of A General Vaccination Programme With The New 10-Valent Pneumococcal Non-Typeable Haemophilus Influenzae Protein-D Conjugate Vaccine (Phid-Cv) In Sweden
Viktigt hålla fast vid principen om värdebaserad prissättning av läkemedel.
The views of physicians and politicians concerning age-related prioritisation in healthcare.
PURPOSE: The aim of this study is to describe the view of age-related prioritisation in health care among physicians and healthcare politicians and to compare their views regarding gender and age. DESIGN/METHODOLOGY/APPROACH: Swedish physicians (n=390) and politicians (n=310), mean age 52 years, answered an electronic questionnaire concerning age-related priority setting in healthcare. The questio
Arab nations lagging behind other Middle Eastern countries in biomedical research: a comparative study.
BACKGROUND: Analysis of biomedical research and publications in a country or group of countries is used to monitor research progress and trends. This study aims to assess the performance of biomedical research in the Arab world during 2001-2005 and to compare it with other Middle Eastern non-Arab countries. METHODS: PubMed and Science Citation Index Expanded (SCI-expanded) were searched systematic
Psychometric properties of the consumer emergency care satisfaction scale: tested on persons accompanying patients in emergency department.
The aim of this study was to investigate construct validity and internal consistency of a modified version of the Consumer Emergency Care Satisfaction Scale used on persons accompanying emergency department patients. The sample comprised 128 persons. The results showed satisfactory reliability, and an exploratory factor analysis revealed 3 factors: caring, teaching, and clinical competence. The mo
The stage-value model: Implications for the changing standards of care.
The standard of care is a legal and professional notion against which doctors and other medical personnel are held liable. The standard of care changes as new scientific findings and technological innovations within medicine, pharmacology, nursing and public health are developed and adopted. This study consists of four parts. Part 1 describes the problem and gives concrete examples of its occurren
A Comparative Approach to the Order of Priority of the Allocation of Taxing Rights over Business Profits in the OECD MC, the UN MC and the Andean Pact MC – The PE broadening. An Argentinean example.
The current OECD´s PE threshold requires either a direct physical presence (fixed place of business) or an indirect presence through a legal representative (dependent agent). On the other hand, Model Conventions such as the UN MC, provide a wider PE threshold, including income generating activities which are not included under the OECD PE threshold. Nevertheless, it should be noted that the UN MC
Ansvar och frihet : en undersökning av att förvalta upphovsrätt och varumärke
Responsibility and freedom : a study in managing copyright and trademark Avsikten med uppsatsen har varit att undersöka sambandet mellan författare och varumärke. Utifrån Moomin Characters Oy och Saltkråkan AB, vilka förvaltar Tove Janssons respektive Astrid Lindgrens rättigheter, har arbetet identifierat verksamheternas varumärken och mål. Varumärken som skiljer sig mellan verksamhet och förfat
Threonine 153 in P47(PHOX) Regulates ROS Production by the NADPH Oxidase NOX2
Unmet medical care and sexual health counseling needs-a cross-sectional study among university students in Uganda
In 2010, unmet medical care and sexual health counseling needs were assessed among students at a Ugandan University. Unmet medical care need was associated with poor mental health, experience of sexual coercion, and poor self-rated health. Unmet sexual health counseling need was significantly associated with being female, coming from an urban area, low social participation, poor mental health stat
Hälsoval skåne : Fler besöker allmänläkare, färre går till specialist
Efter införande av Hälsoval Skåne har andelen av befolkningen som besökt allmänläkare ökat, liksom antalet besök per invånare. Ökningarna är överlag måttliga, med undantag för äldre män med lägre inkomst, där ökningen är större.Det finns också en minskning av besöken till övriga specialistläkare så att det totala antalet läkarbesök per invånare minskat i vissa grupper. Färre besök hos övriga speci
The Proposed Regulation on a Common European Sales Law (CESL) as an Alternative to the Convention on the International Sale of Goods (CISG) in Transnational Business-to-Business Transactions?
The Commission has put forth a proposal for a Regulation on a Common European Law of Sales (CESL). It is envisaged – as of now – as an optional second regime within each member state‘s law, electable for transnational consumer contracts and contracts among traders, as long as one of them is a small or medium-sized enterprise. The intention is to provide contractors with a level playground of one l
Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.
We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR
European Identity from Below : The Presence of Eurosymbols in Two European Capitals
Abstract in UndeterminedIdentity construction processes have been studied at the national level both from top-down (elite driven process) and from bottom-up (popular movements). In the context of European identity research, Billig's argument for "banal nationalism" has been transposed to the scale of the region by Cram under the name "banal europeanism". The present paper wants to test the process
Administration of rosehip and Lactobacillus plantarum DSM 9843 reduces lipid peroxidation after colonic ischemia in mice
Very fast photon counting photometers for astronomical applications: from QuantEYE to AquEYE
Occurence of hypothermia in a prehospital setting, southern Sweden
Abstract Severe accidental hypothermia mainly affects victims of outdoor accidents. However, hypothermia can also occur in non-traumatized indoor patients. The aim of this study was to examine the occurrence of hypothermia obtained at the scene of the rescue in patients classified as priority 1 cases during two three-month periods in southern Sweden. This prospective, clinical cohort study was per
