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Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline during aging is poorly understood. Here, we identify CXCR5/5/CXCL13 signaling as a novel regulator of neuroge
The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell
Erythropoiesis is intimately coupled to cell division, and deletion of the cell cycle regulator retinoblastoma protein (pRb) causes anemia in mice. Erythroid-specific deletion of pRb has been found to result in inefficient erythropoiesis because of deregulated coordination of cell cycle exit and mitochondrial biogenesis. However, the pathophysiology remains to be fully described, and further chara
Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatme
A reduced-order through-flow program has been developed at the Lund Institute of Technology. The goal of the work was to develop and verify a program suitable for scientific studies of coaxial turbines. The program has built-in capability for multiple choked stages, and turbine cooling, as well as flexible modules for state, losses, deviation, and blockage. The code uses Matlab [trademark] as a pl
Skogar har en positiv inverkan på halten av växthusgaser i atmosfären eftersom de binder koldioxid via fotsyntesen och lagrar kol i marken. Dessutom utgör många skogar en betydande sänka för växthusgasen metan. Upptaget av metan sker i väl syresatta marker genom oxidation utförd av metanotrofa bakterier. Däremot sker en nettoproduktion av metan i syrefattiga skogsmarker när mikroorganismer, s.k. aPopular Abstract in English Forests have a positive impact on the level of greenhouse gases in the atmosphere because they absorb carbon dioxide through photosynthesis and store carbon in the soil. Moreover, many forests function as a sink for the greenhouse gas methane (CH4). The uptake of CH4 takes place in well-aerated soils through oxidation by methanotrophic bacteria. However, there is a net
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study"
To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), we employed a genome-wide RNAi screen in human cord-blood derived cells and identified candidate genes whose knockdown maintained the HSC phenotype during culture. A striking finding was the identification of members of the cohesin complex (STAG2, RAD21, STAG1, and SMC3) among the top 20 genes from the screen. Upon
Innehåll: Ledare (Michael Tapper), Geometry of Force: Abel Ferrara och Simone Weil (Tag Gallagher), Lang & Brecht (Robin Wood), Tankar kring filmens estetik (Georg Lukács), Kommentar till Lukács (Jakob J Norberg), Exotisk esteti: Kenji Mizoguchi och Josef von Sternberg (Tim Palmer), Recensionsessä böcker: Mediedidaktikens villkor (Lars Gustaf Andersson), Recensionsessä film: Philip K Dick, the
Popular Abstract in Swedish Movimiento al Socialismo (MAS) bildade regering i Bolivia 2006 med Evo Morales på presidentposten, framburna av folkliga protester mot tidigare, nyliberala regimer. Morales beskrivs ofta som landets första president med bakgrund i ursprungsbefolkningen. Hans regering utlovade en radikal omställning av den nationella politiken och tillkännagav att Bolivia nu är en "pluriEvo Morales and the Movimiento al Socialismo (MAS) took office in Bolivia in 2006, riding on the wave of fierce popular protests against previous, neoliberal regimes. Morales was depicted as the country’s first indigenous president. His government promised a radical transformation of national politics and rebranded Bolivia as a “plurinational state”. Under MAS, indigenous subjectivity has moved fr
Cellulosa är den vanligaste biopolymeren på jorden och en viktig reservoar av organiskt kol i terrestra ekosystem. I skogar kommer mycket av denna cellulosa från trä och bryts ner av saprotrofa basidiomyceter. Dessa svampar klassificeras traditionellt som vitröta eller brunröta baserat på deras sönderfallsmekanismer i lignocellulosasubstrat. Huruvida dessa funktionella kategorier förblir distinktaCellulose is the most abundant biopolymer on Earth and a major reservoir of organic carbon in terrestrial ecosystems. In forests, much of this cellulose originates from wood and is decomposed by saprotrophic basidiomycetes. These fungi are traditionally classified as white rot or brown rot species based on their decay mechanisms in lignocellulosic substrates. Whether these functional categories re
BACKGROUND: Type 2 diabetes mellitus (T2DM) is common among people with HIV (PWH), although studies comparing T2DM-related complications in people with and without HIV (PWoH) remain limited. This was assessed using data from the Cohort Study on Morbidity and HIV in Sweden (COSMOHS).METHOD: Nationwide study including Swedish residents born 1930-2006, diagnosed with T2DM between 2010 and 2019, follo
Bokning av provtillällen Bokning av provtillfällen Instruktioner 1. Fyll i de blå fälten med information som efterfrågas i vänsterkolumen. Se Exempel. 2. Ladda upp filen i formuläret på https://www.student.med.lu.se/formular/anmalan-provtillfalle Exempel Anmäl tillfälle 1 nedan Anmäl tillfälle 2 nedan Anmäl tillfälle 3 nedan Anmäl tillfälle 4 nedan Anmäl tillfälle 5 nedan Anmäl tillfälle 6 nedan A
https://www.student.med.lu.se/sites/student.med.lu.se/files/2021-04/Mall%20-%20provanmalan.xlsx - 2026-05-17
Popular Abstract in Swedish Under den senaste tiden har problematiken med klimatförändringarna debatterats livligt. För att kunna förutspå den framtida omfattningen av klimatförändringarna och vilka konsekvenser dessa kommer att ha är det ytterst relevant att känna till utbytet av växthusgaser mellan atmosfär och jordens alla ekosystem. Arktiska ekosystem är ytterst känsliga för den globala uppvärArctic ecosystems play a key role in the terrestrial carbon (C) cycle, but spa-tially explicit data on the C exchange is scarce in these remote areas. The global warming is especially dominant in the Arctic, and these areas are vul-nerable to climate change. It is therefore important to quantify and understand the processes affecting the C dynamics in these regions. In this thesis, the land-atmosp
Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr
Background: The Southern Swedish Malignant Melanoma (SSMM) research team is a truly cross functional group with members from oncology, clinical, surgery, bioinformatics, proteomics, and genomics initiatives. The SSMM’s objectives and goals are to develop, build and utilize cutting edge biobanks and OMICS platforms to better understand disease pathology and drug mechanisms. Within the research team
Based upon earlier experimental work by our group, we have started a human immuno-gene therapy study. The goal is to study the effects of immunisation with autologous tumour cells expressing gene sequences for human interferon-gamma For more than two decades we have sought for efficient treatment against malignant gliomas. Our most successful treatment in the animal models is immuno-gene therapy w
Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour
BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin
