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New methods and applications in the separation of biomolecules are reviewed, with an emphasis on the large-scale recovery of proteins. Highlights include the advent of flow-through particles in perfusion chromatography, which allows for very high flow rates, while retaining a high chromatographic efficiency.
Purpose: This study aimed to investigate the rate of re-ascent requiring re-operation after primary orchidopexy and to investigate eventual differences between the inguinal and scrotal approach as well as other potential predictors for re-ascent. Methods: A retrospective cohort study of children treated for undescended testis (UDT) with orchidopexy between 2018 and 2022 was conducted. The primary
Global in its outlook, this Research Agenda systematically reviews and critiques existing research on sustainable cities, calling for greater engagement with a diversity of perspectives. It interrogates foundational assumptions in the field and offers reframed perspectives on sustainability. Chapters also explore diverse approaches, actors and domains, locating emerging dynamics and new directions
This paper investigates employment outcomes for a large sample of Ph.D. students who were enrolled in a doctoral training program in Italy in the period 2008–14. The empirical analysis is based on survey data obtained from a questionnaire distributed to 23,500 individuals in 2016. In Italy, student enrolment in a Ph.D. involves a university-based selection process; most students then receive eithe
Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with respiratory failure where the gas exchange capacity of the lung is compromised. Venous blood is pumped through an oxygenation unit outside of the body where oxygen diffusion into the blood takes place in parallel to carbon dioxide removal. ECMO is an expensive therapy which requires special expertise to perform.
Traditionally, alkaline water electrolysis (AWE) uses diaphragms to separate anode and cathode and is operated with 5–7 M KOH feed solutions. The ban of asbestos diaphragms led to the development of polymeric diaphragms, which are now the state of the art material. A promising alternative is the ion solvating membrane. Recent developments show that high conductivities can also be obtained in
Aging exerts profound effects on the hematopoietic system, leading to a loss of homeostatic control and reduced regenerative capacity. Clinical consequences of these changes include anemia, compromised immune function and an increased prevalence of myeloid disorders among the elderlies. A growing body of evidence suggests that defects at the stem and progenitor cell levels contribute to many of th
The use of focused X-ray beams in the micron and sub-micron range has fostered the progress of a wide range of scanning microscopy approaches that exploit the numerous interactions of X-rays with matter. These methods are becoming crucial for an increasing number of research fields, such as energy materials, electronic devices, biology, to cite a few. Nanobeams produced at 4th generation synchrotr
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by diverse presentations and a strong genetic component. Environmental factors, such as prematurity, have also been linked to increased liability for ASD, though the interaction between genetic predisposition and prematurity remains unclear. This study aims to investigate the impact of genetic liability and
Quadruped robots are currently a widespread platform for robotics research, thanks to powerful Reinforcement Learning controllers and the availability of cheap and robust commercial platforms. However, to broaden the adoption of the technology in the real world, we require robust navigation stacks relying only on low-cost sensors such as depth cameras. This paper presents a first step towards a ro
Black-box policy optimization is a class of reinforcement learning algorithms that explores and updates the policies at the parameter level. This class of algorithms is widely applied in robotics with movement primitives or non-differentiable policies. Furthermore, these approaches are particularly relevant where exploration at the action level could cause actuator damage or other safety issues. H
High-risk neuroblastoma (NB) is a rare, solid childhood cancer with poor prognosis due to treatment resistance and metastasis. Improved patient outcome is dependent on the understanding of the resistance mechanisms and subsequent development of novel treatment options.In Paper I, we established a clinically relevant in vivo treatment protocol using current standard-of-care chemotherapy (COJEC). We
Enzymes serve as biological catalysts in a wide range of applications, from household products to industrial processes, research, diagnostics and forensic science. They accelerate reactions with high specificity under mild reaction conditions and are essential for life. Advances in recombinant DNA technology have enabled the use of microorganisms as efficient cell factories for production of heter
LIDAR techniques have been extensively used for studies of aerosol particles. Fluorescence LIDAR was employed for studying natural bio aerosols, such as pollen, but also possible warfare agents. Insects, being "large aerosol" particles clearly give rise to LIDAR returns. Recently, honey bees were studied by polarization reflectance LIDAR and their superior olfactory abilities were used in attempts
Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researc
Popular Abstract in Swedish Idag kan vi mäta mycket låga halter av gifter i t. ex. dricksvatten och livsmedel, bland annat genom utvecklingen av nanosensorer. Sensorerna kan också använda's medicinskt, t. ex för att väsentligt underlätta livet för diabetiker. Idag drabba's diabetespatienter ofta av nedsatt känsel i fingrarna på grund av dagliga nålstick. Med hjälp av de nya sensorerna kan vi nu mäA new type of Bioelectronic Nanosensor Device with potential applications in medicine,biotechnology and environmental analysis was designed. The nanosensor is based on RISFET (Regional Ion Sensitive Field Effect Transistor) technology. The design of the nanosensor involves use of a set of nano-sized electrodes on the surface of a silicon chip, giving the chip the ability to sense extremely low con
