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Objective To develop evidence-based recommendations on the use of imaging of the joints in the clinical management of rheumatoid arthritis (RA). Methods The task force comprised an expert group of rheumatologists, radiologists, methodologists and experienced rheumatology practitioners from 13 countries. Thirteen key questions on the role of imaging in RA were generated using a process of discussio
Cutaneous Leishmaniasis (CL) is an endemic vector-borne disease in the Middle East and a worldwide public health problem. The spread of CL is highly associated with the socio-ecological interactions of vectors, hosts and the environment. The heterogeneity of these interactions has hindered CL modeling for healthcare preventive measures in endemic areas. In this study, an agent-based model (ABM) is
Over the years we have seen an increased interest in businesses and in research for how to create conditions for entrepreneurship in established businesses (referring to corporate entrepreneurship). From research we know that access to and use of resources is critical for realizing corporate entrepreneurship activities. Even though the role of resources has been examined this conceptual paper iden
Although genotype-by-environment interaction has long been used to unveil the genetic variation that affects Darwinian fitness, the mechanisms underlying the interaction usually remain unknown. Genetic variation at the dimeric glycolytic enzyme phosphoglucoisomerase (Pgi) has been observed to interact with temperature to explain the variation in the individual performance of the butterfly Melitaea
Vehicle design is characterized by a high number of compromises. The special role of human factors in the process is to ensure that the compromises do not occur at the expense of the driver and passengers. Within the automotive industry there is a need for the development of inexpensive and efficient ergonomic tools, facilitating a fast and cost effective car development process as well as discuss
Enhancement of cAMP degradation by increased cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) activity is thought to be an important component of the mechanism whereby insulin counteracts catecholamine-induced lipolysis in adipocytes. In this study the selective cGI-PDE inhibitor OPC3911 was used to evaluate this role of cGI-PDE activation in intact rat adipocytes with special reference to changes
Popular Abstract in Swedish Betændelses reaktionen er kroppens svar på en skade eller en infektion. Betændelses reaktionen gør at immunforsvarets celler kaldes til det skadede område (kan ses som den røde varme hævelse omkring et sår) og at eventuelle sygdomsfremkaldende emner identificeres og bekæmpes. På lidt længere sigt, fjernes ødelagt væv og helingen af såret påbegyndes. Når det skadede områThe pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. Since leukotrienes have been shown in increased concentrations in stools of IBD patients we hypothesise that LTD4 can play a role in the deve
Cellobiose dehydrogenase (CDH) is a fungal extracellular flavocytochrome capable of direct electron transfer (DET). Unlike other CDHs, the pH optimum for CDHs from Corynascus thermophilus (CtCDH) and Humicola insolens (HiCDH) is close to the human physiological pH in blood (7.4). These are, therefore, interesting candidates for glucose measurements in human blood and the application in enzymatic f
Ever since the invention of the internal combustion engine, there has been an interest in optimizing the in-cylinder pressure to achieve reliable and efficient work output. With the use of in-cylinder pressure sensors, piezoelectric injector actuation, the possibility of multiple injection events and the increased availability of computation power, cycle-to-cycle, in-cylinder pressure optimization
Modelica allows systems to be described with reuseable components and with a high precision. To be able to use such complex models efficiently, high demands are set on tools that allow the user to extract the information needed from the models in a straight-forward manner. For this purpose, design-of-experiments techniques can be used to systematically analyze the complex models.In this paper, it
To obtain full sky coverage, astronomical adaptive optics systemsrequire Na Sodium Beacons (SBs) (also referred to as Laser Guide Starsor LGSs) located at heights extending from 85 to 100 km. When viewed atthe edge of large telescopes these SBs appear elongated. For the Euro5050 meter aperture telecopes this elongation amounts to 6 to 9 arcsecondswhen the laser is launched from a point on the tele
Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut
Partially Premixed Combustion (PPC) is a promising advanced combustion mode for future engines. In order to investigate the sensitivity of PPC to exhaust gas recirculation (EGR) rate, intake gas temperature, intake gas pressure, and injection timing, these parameters were swept individually at three different loads in a single cylinder diesel engine with gasoline-like fuel.A factor of sensitivity
BACKGROUND: Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-lar
