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Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell frag

In order to maximize their fitness, individuals aim at choosing territories offering the most appropriate combination of resources. As population size fluctuates in time, the frequency of breeding territory occupancy reflects territory quality. We investigated the relationships between the frequency of territory occupancy (2002-2009) vs. habitat characteristics, prey abundance, reproductive succes

Scientific performance is often evaluated by bibliometric indicators such as publication counts or citations. But this may neglect other relevant outputs from research units. An optimal evaluation would measure each dimension separately, but this would be costly. Luckily, cluster analyses show that units which specialise in other types of research activities (such as knowledge transfer or educatio

To increase the market share of hybrid vehicles within the automotive industry, it is necessary to minimize the cost increase related to the hybridization. In this context a methodology to estimate the cost of the electrical machine and transmission is developed. Insights on the selection of a cost effective electrical machine topology are provided and the benefits and disadvantages of different d

Aim: Understanding the spatial ecology of animal movements is a critical element in conserving long-lived, highly mobile marine species. Analyzing networks developed from movements of six sea turtle species reveals marine connectivity and can help prioritize conservation efforts. Location: Global. Methods: We collated telemetry data from 1235 individuals and reviewed the literature to determine ou

The energy sector is in urgent need for carbon-free strategies considering environmental pollutions and climate change impact. Two kinds of solid fuels, biomass and metal particles have been studied in this thesis aiming at CO2 emission reduction or zero carbon emission. Biomass is a renewable and carbon-neutral energy source that provides heat and power through gasification and combustion. Biomas

Biomaterials represent a potential means for the construction industry to reduce its negative ecological impact. These materials require substantially different approaches from conventional construction materials to maximise their potential. In this paper we have outlined four principles of biological design that we argue are central for the successful implementation of a new construction paradigm

This article explores the burgeoning Nepalese hip-hop scene – commonly known as nep-hop – as a discursive intervention in the post-war politics of Nepal. Its core argument is that nep-hop oftentimes demonstrates an ethos of peacebuilding through popular culture. Indeed, many songs explicitly criticize violence, war, and the political leaders who recently brought the nation to a civil war. Yet, thi

In Streamflow prediction the most important triggering/controlling variables are related to climate, physiography, and landscape patterns. This study investigated the effect of different landscape metrics to relate spatial patterns to surface runoff processes and predict monthly streamflow using climatic and physiographic variables for the 42 sub-basins of the Urmia Lake Basin in Iran. We develope

Here, we describe a detailed step-by-step protocol for the expression, purification, quantification, and activity determination of key enzymes for molecular detection of pathogens. Based on previous reports, we optimized the protocol for LbCas12a, Taq DNA polymerase, M-MLV reverse transcriptase, and TEV protease to make it compatible with minimal laboratory equipment, broadly available in low- and

The effect of freestream turbulence on the flow past a circular cylinder (tube) was studied experimentally for Reynolds numbers between 2 x 104 and 6 x 104. Investigations were carried out for uniform (non-turbulent) flow and for turbulent flows having turbulence intensities between 1.3 and 4.1%. The variations in the pressure forces and shedding frequencies were found to be related to the variati

Animal migration is one of the most spectacular and visible behavioural phenomena in nature with profound implications for a range of ecological and evolutionary processes. Successful migration hinges on the ability to exploit temporary resources (e.g. food) and evade threats (e.g. predators) as they arise, and thus the timing of migration is often regarded as a dominant predictor of individual mi

Sharing is considered as one of the key elements in circular economy, as well as away to deliver social impact. According to the New Bauhaus initiative by the EuropeanCommission, new neighbourhoods should be environmentally sustainable, provide anaesthetic experience, and deliver social inclusion. This study explores the emergence of sharing business models in the real estate industry. The aim is