Filtyp
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new lo
Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding important functionality. We introduce an internal time-limited charge-based memory into a III-V nanowire (NW) based optoelectronic neural node circuit designed for handling optical signals in a neural network. The new circuit can receive inhibiting and exciting light signals, store them, perform
Background: Patients with bacteraemia caused by gram-positive bacteria are at risk for infective endocarditis (IE). Because IE needs long antibiotic treatment and sometimes heart valve surgery, it is very important to identify patients with IE. Objectives: In this narrative review we present and discuss how to determine which investigations to detect IE that are needed in individual patients with
Constructed wetland (CW), a green wastewater treatment technology, is extensively used in the world owing to its advantages of less investment, low energy consumption, simple operation and maintenance, and satisfactory purification effect. Currently, with the promotion of CW application, a variety of problems have been gradually exposed. This paper summarizes the common problems of CWs, including
During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to
Background: Insomnia is common in adolescents. This study evaluated feasibility and preliminary efficacy of a six-week internet-delivered cognitive-behavioral therapy for insomnia (ICBT-I) in adolescents. Methods: In this uncontrolled pilot study, participants (n = 27, 78% female) completed assessments pre- and post intervention. Data on recruitment, adherence to treatment, treatment activity, sat
This paper explores how three cognitive and perceptual cues, vocal iconicity, resemblance-based mappings between form and meaning, and segment position and lexical stress, interact to affect word formation and language processing. The study combines an analysis of the word-internal positions that iconic segments occur in based on data from 245 language families with an experimental study in which
It is important for utilities to plan for Distributed Energy Resources (DER) uptake by representing and modelling their characteristics using appropriate assumptions, methods and tools. Large-scale DER deployment impacts power flows and power system performance in various complex ways as well as potentially contributing to ancillary services. In this paper, we explore state of the art planning me
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthines (caffeine; theophylline or aminophylline) and 'no methylxanthine administration' on morbidity and mortality in preterm infants, using network meta-analysis.
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave th
To understand, predict and mitigate climate change, it is crucial to have long-term and standardised measurements of greenhouse gas concentrations in the atmosphere and their fluxes between atmosphere, land and oceans. The Integrated Carbon Observation System, is a distributed European Research Infrastructure which provides high-precision and highly standardised observations from more than 170 sta
Pentachlorophenol (PCP) is a commonly found recalcitrant and toxic groundwater contaminant that resists degradation, bioaccumulates, and has a potential for long-range environmental transport. Taking proper actions to deal with the pollutant accounting for the life cycle consequences requires a better understanding of its behavior in the subsurface. We recognize the huge potential for enhancing de
Epstein Barr Virus (EBV) has been recognized for its ability to transform B lymphocytes and for its association with different types of cancers including Hodgkin lymphoma. In addition, EBV may also modulate the microenvironment of HL. In this study, we aimed to investigate the prevalence of EBV among HL cases in Ethiopia and to assess the tissue cellular composition of EBV-related and EBV-unrelate
Background: Most family studies on venous thromboembolism (VTE) have focused on first-degree relatives. Objectives: We took a pedigree-based approach and examined the risk of VTE and cardiometabolic disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: From the Swedish population, we identified a total of 482 185 pedigrees containing a mean of 14.2
Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con
Introduction: Dementia is a condition (a collection of related signs and symptoms) that causes a continuing deterioration in cognitive function, and millions of people are impacted by dementia every year as the world population continues to rise. Conventional approaches for determining dementia rely primarily on clinical examinations, analyzing medical records, and administering cognitive and neur
Policies for shifting household electricity load are in focus in several countries, aimed at optimizing grid operation and tackling current and expected challenges from consumption patterns, like increased peak loads on the grid. Central here are recent developments in capacity charges, where the use of significant amounts of grid capacity is priced high, compared to the traditional pricing of ele
Context: The capacity of a landscape to maintain multifunctionality through ongoing pressures relates to its sustainability and is affected by land use policy and environmental changes. In coastal zones, limited empirical evidence exists regarding the impact of macro-level policy changes on local landscapes and their resulting temporal and spatial responses. Objectives: This paper investigates the
