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Novel methods of malignant brain tumor treatment utilizing the tumor microenvironment

Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. Ever since the early 2000’s, no major improvement of patient outcomes occurred. Immu

Care in the air? Atmospheres of care in Swedish pharmacies

This article builds upon literature on materialities of care and departs from a relational view of care and place. Using the concept of atmosphere, it investigates how care practices are situated spatially and temporally in pharmacies. In many countries, pharmacies are viewed as an important sector in formal healthcare systems. Rarely discussed in pharmacy literature is the affective and embodied

Fast and well-reported implementation: Fast-IM and RE-AIM.

Background Implementation in healthcare is often slow and poorly reported. Results include suboptimal outcomes and ad-verse consequences for patients. However, promising tools to remedy implementation speed and reporting already exist – such as the evidence-based, fast-track implementation model (Fast-IM) and the comprehensive RE-AIM (reach, effectiveness, adoption, implementation, and maintenance

Camouflaging as identity work : A study of how professionals position themselves in the intersection of professional work and sales work

This paper examines how professionals position themselves and negotiate their identity in the intersection of professional work and sales work in the context of two professional service firms. We propose the concept of camouflaging as identity work to illustrate how professionals (re)construct their identity and position themselves as professionals by integrating and blurring the lines between the

Structural Profiling of Lipid Nanoparticles at Sub-10 nm Resolution via AF4 Coupled Online to SAXS and SANS

Precise mapping of structural heterogeneity at the sub-10 nm scale is pivotal for rational nanoparticle design, yet conventional analytical workflows remain inadequate. Here we integrate dilution-controlled asymmetric flow field-flow fractionation (AF4) with small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) to interrogate ellipsoidal solid–liquid lipid nanoparticles (LN

The Locomotor Capabilities Index; validity and reliability of the Swedish version in adults with lower limb amputation

Background: The Locomotor Capabilities Index (LCI) is a validated measure of lower-limb amputees' ability to perform activities with prosthesis. We have developed the LCI Swedish version and evaluated its validity and reliability. Methods: Cross-cultural adaptation to Swedish included forward/backward translations and field testing. The Swedish LCI was then administered to 144 amputees (55 women),

On the welfare theoretic foundation of cost-effectiveness analysis-the case when survival is not affected

This paper develops a welfare theoretic foundation for cost-effectiveness analysis (CEA) when survival is not affected. With this foundation, all costs and their corresponding utility-terms should be included. A key question, though, is whether these utility-terms are consistent with quality-adjusted life year (QALY) (utility) theory or not. The results show that health care costs and changes in t

The first national pressure ulcer prevalence survey in county council and municipality settings in Sweden.

Aim: To report data from the first national pressure ulcer prevalence survey in Sweden on prevalence, pressure ulcer categories, locations and preventive interventions for persons at risk for developing pressure ulcers. Methods: A cross-sectional research design was used in a total sample of 35 058 persons in hospitals and nursing homes. The methodology used was that recommended by the Europea

Development of decay performance models for outdoor timber structures

Performance based building (PBB) and design is closely connected to various needs and requirements: Performance levels need to be defined, test methods for verification of performance need to be developed, and reliable performance data are needed for materials, products, constructions, and different design solutions. In contrast to other building materials, PBB and thus service life prediction of

Performance of health-status scales when used selectively or within multi-scale questionnaire

BACKGROUND: Little work has been done to investigate the suggestion that the use of selected scales from a multi-scale health-status questionnaire would compromise reliability and validity. The aim of this study was to compare the performance of three scales selected from the SF-36 generic health questionnaire when administered in isolation or within the entire SF-36 to patients with musculoskelet

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Abstract in Danish Ph.d. Dissertation, published as a book

A Review of the Eurodiale Studies: What Lessons for Diabetic Foot Care?

The prevalence of diabetes has been increasing at an alarming rate worldwide. Treatment of diabetes-related complications adds a huge financial burden on our health services, made worse in the current financial climate. The Eurodiale (European Study Group on Diabetes and the Lower Extremity) study was a prospective observational study conducted in 14 European centers in 2003 to 2004 and included d

Forgetting to remember or remembering to forget: A study of the recall period length in health care survey questions.

Self-reported data on health care use is a key input in a range of studies. However, the length of recall period in self-reported health care questions varies between surveys, and this variation may affect the results of the studies. This study uses a large survey experiment to examine the role of the length of recall periods for the quality of self-reported hospitalization data by comparing regis

Quality indicators for palliative and end of life care: a review of Swedish policy documents.

All patients with palliative and end of life care needs should be guaranteed equal and safe treatment and care, regardless of their disease or site of care. The inclusion of quality indicators in national guidelines and other guiding documents supports quality assurance and improvement in provision of care. The aim of this paper was to review existing quality indicators in national Swedish policy

Body Size, Skills, and Income: Evidence From 150,000 Teenage Siblings

We provide new evidence on the long-run labor market penalty of teenage overweight and obesity using unique and large-scale data on 150,000 male siblings from the Swedish military enlistment. Our empirical analysis provides four important results. First, we provide the first evidence of a large adult male labor market penalty for being overweight or obese as a teenager. Second, we replicate this r

The impact of price reductions on individuals' choice of healthy meals away from home

Food high in energy but low in nutritional value is an important contributor to several serious illnesses, and one type of food that is particularly high in energy but low in nutrition is food consumed away from home. In this paper, we examine the demand and willingness to pay for healthy, Keyhole-labelled meals. A Keyhole-labelled meal is particularly low in energy, fat, sugar and salt, but parti