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Chains of risk for alcohol use disorder : Mediators of exposure to neighborhood deprivation in early and middle childhood

Our goal was to test a cascade model to identify developmental pathways, or chains of risk, from neighborhood deprivation in childhood to alcohol use disorder (AUD) in young adulthood. Using Swedish general population data, we examined whether exposure to neighborhood deprivation during early and middle childhood was associated with indicators of social functioning in adolescence and emerging adul

Is familial risk for depression confounded by individual and familial socioeconomic factors and neighborhood environmental factors? A 7-year follow-up study in Sweden

Family history of depression is an important risk factor for depression. The aim of this study was to examine whether the effect of family history of depression is confounded by individual and familial socioeconomic factors (i.e., country of origin, educational attainment, family income and mobility) and neighborhood environmental factors (i.e., neighborhood deprivation and neighborhood social cap

Innovation Policies and New Regional Growth Paths : A Place-Based System Failure Framework

Fundamental and enduring changes brought about by recurrent economic and financial crises, the digital revolution and ongoing globalisation processes of production and innovation activities are posing major challenges for regional and national economies to renew their industrial structures and develop innovations that break existing development trajectories. This calls for new innovation policy ap

Molecular interactions between quinoa, the biocontrol agent Trichoderma and the pathogen Peronospora variabilis

Plants have developed complex molecular mechanisms to recognize and respond to the different microorganisms present in their surroundings. The most studied response mechanisms are plant defense responses. These defense response mechanisms share many similar components with the plant response mechanisms to beneficial microbes. Therefore, studying the defense response mechanisms against pathogens caPlants have developed complex molecular mechanisms to recognize and respond to the different microorganisms present in their surroundings. The most studied response mechanisms are plant defense responses. These defense response mechanisms share many similar components with the plant response mechanisms to beneficial microbes. Therefore, studying the defense response mechanisms against pathogens ca

In-situ SEM study of fracture of an ultrathin Al-foil-modelling of the fracture processes

Fracture behavior of an ultra thin Aluminium foil was studied. For very short crack lengths, fracture has been followed in the scanner electronic microscope (SEM) with a tensile stage. A single edge notched tension specimen was used. Crack length and applied load during the crack growth were measured. These results have been used to calculate fracture strength using linear elastic fracture mechani

Phenotypic characterization of acoustically enriched extracellular vesicles from pathogen-activated platelets

Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive cargo from the parent cells. Platelet activation and release of EVs increases in several pathological inflammatory diseases, such as se

Risk of second primary cancers after malignant mesothelioma and vice versa

We aimed at investigating risk of specific second primary cancers (SPCs) after malignant mesothelioma (MM) and vice versa, which has not been reported. Among survivors of 3672 pleural MM and 895 peritoneal MM, overall 113 and 28 SPCs were recorded, respectively, while reverse analyses included overall 431 pleural and 88 peritoneal MMs after any first cancers. We found a bidirectional association o

Caught Between Spaces : Socio-Environmental Vulnerability in Formal and Informal Peri-Urban Bogotá and Soacha, Colombia

Världens städer växer i snabb takt. Denna avhandling undersöker välbefinnandet och sårbarheten hos befolkningen i stadsnära, eller periurbana, låginkomstområden i och runt Bogotá, Colombia, med målet att öka förståelsen för hur sociala och miljömässiga förutsättningar påverkas av stadsutbredning och förtätning.För detta syfte har jag utvecklat en typologi för periurbana bosättningar som består av The world is rapidly urbanizing. To contribute to the understanding of the socio-environmental changes brought about by urban sprawl and densification, this thesis examines wellbeing and vulnerability in low-income peri-urban areas in and around Bogotá, Colombia. For that purpose, I develop a typology of peri-urban settlements that includes four main settlement classifications: agriculture-based,

Localization of a novel melanoma susceptibility locus to 1p22

Over the past 20 years, the incidence of cutaneous malignant melanoma (CMM) has increased dramatically worldwide. A positive family history of the disease is among the most established risk factors for CMM; it is estimated that 10% of CMM cases result from an inherited predisposition. Although mutations in two genes, CDKN2A and CDK4, have been shown to confer an increased risk of CMM, they account

Preterm Children Born Small for Gestational Age are at Risk for Low Adult Bone Mass.

Cross-sectional studies suggest that premature birth and low birth weight may both be associated with low peak bone mass. We followed bone traits in preterm individuals and controls for 27 years and examined the effects of birth weight relative to gestational age [stratified as small for gestational age (SGA) or appropriate for gestational (AGA)] on adult bone mineral density (BMD). We measured di

Cannabis use, mental health, and problematic Internet use in Quebec : A study protocol

Background Problematic Internet use is characterized by excessive use of online platforms that can result in social isolation, family problems, psychological distress, and even suicide. Problematic Internet use has been associated with cannabis use disorder, however knowledge on the adult population remains limited. In Quebec, cannabis use has significatively increased since 2018, and it is associ

IFNγ+ NKT-like cells are associated with increased incidence of atrial fibrillation in elderly women

Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of developing AF. Methods and results T-cell subsets, measured by flow cytometry of cryopreserved mononuclear leucocytes isolated from blood at baseline, were analysed

Unimaginable imagination and political commitment : A survey of the introduction and presence of the literature of the Latin American boom in Sweden in 1960–1990

This study investigates the publication and reception of the Latin American boom literature in Sweden from 1960 to 1990, focusing on Julio Cortázar, Carlos Fuentes, Gabriel García Márquez and Mario Vargas Llosa. It analyses the extent of Swedish translations of their works and the type and amount of attention they received in the Swedish press. Using a bibliometric approach for the translations, a

The Rage of the Subaltern : The Violencing Hand of the Market

This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?This research project aims to explore and theorize the role of the Market in a hyperviolence-endorsing consumer culture. How does the subaltern speak through “gangfluencers” in a Global North welfare society, and how do affective intensities of consumer desire enact the violent consumer subject herein?

Acoustic Enrichment of Heterogeneous Circulating Tumor Cells and Clusters from Metastatic Prostate Cancer Patients

BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on the microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS

Making Independent Decisions Together : Rational Emotions in Legal Adjudication

This article analyzes rational decision-making in court as an emotivecognitiveprocess formed in and through social interaction. Currenttheoretical perspectives have shown how emotion and thought areintertwined in the workings of the human brain but have seldom elaboratedon the contextual and structural features of rational-emotionaldecision-making. I propose a model that maps emotional processesanThis article analyzes rational decision-making in court as an emotivecognitiveprocess formed in and through social interaction. Currenttheoretical perspectives have shown how emotion and thought areintertwined in the workings of the human brain but have seldom elaboratedon the contextual and structural features of rational-emotionaldecision-making. I propose a model that maps emotional processesan