Filtyp
Genes encoding the DNA helicase TWINKLE (C10orf2) or the two subunits of mtDNA polymerase γ (POLγ) (POLG1 and POLG2) have a direct effect on the mitochondrial DNA replication machinery and were reported in many mitochondrial disorders. Friedreich's ataxia (FRDA) is the common cause of ataxia often associated with the expansion of a GAA repeat in intron 1 of the frataxin gene (FXN). Mitochondrial D
Rotor-stator mixers (RSMs) can be operated in either batch or inline mode. When operating a rotor-stator geometry in batch mode, it typically experiences an order of magnitude higher volumetric flow through the stator than in inline mode. This is expected to cause differences in the flow and turbulence in the rotor-stator region. This study uses computational fluid dynamics (CFD) to study the hydr
Soil organic matter (SOM) supports the Earth's ability to sustain terrestrial ecosystems, provide food and fiber, and retains the largest pool of actively cycling carbon. Over 75% of the soil organic carbon (SOC) in the top meter of soil is directly affected by human land use. Large land areas have lost SOC as a result of land use practices, yet there are compensatory opportunities to enhance prod
Twenty Apolipoprotein A-I (ApoA-I) variants are responsible for a systemic hereditary amyloidosis in which protein fibrils can accumulate in different organs, leading to their failure. Several ApoA-I amyloidogenic mutations are also associated with hypoalphalipoproteinemia, low ApoA-I and high-density lipoprotein (HDL)-cholesterol plasma levels; however, subjects affected by ApoA-I-related amyloid
During the winter and spring of 2006, Denmark and Scandinavia faced its most serious crisis since World War II. The conflict started as a Danish newspaper published a number of cartoons, some of which portrayed the prophet Muhammad. After the Danish government rejected their requests to censor the media, Danish Islamists distributed these pictures to some senior political and religious figures in
Sweden is a diverse and multilingual place. Today’s students represent a broad spectrum of cultural, linguistic, and socioeconomic backgrounds. Sweden is also a site for mobility as people flow in and out through processes of migration, tourism, international trade, and study abroad. It is in this context that English is taught in Swedish upper secondary schools. The subject of English in Sweden,
Laser-wakefield accelerators (LWFAs) are high acceleration-gradient plasma-based particle accelerators capable of producing ultra-relativistic electron beams. Within the strong focusing fields of the wakefield, accelerated electrons undergo betatron oscillations, emitting a bright pulse of X-rays with a micrometer-scale source size that may be used for imaging applications. Non-destructive X-ray p
Limited guidance is available to engineers on how people's walking speed in smoke can and should be represented in the fire safety design process of underground transportation systems, such as road and rail tunnels. To address this issue, the behaviour and movement of people in case of evacuation due to a fire in underground transportation systems has been investigated. In this paper, the relation
The registration of an observed point set to a known model to estimate its 3D pose is a common task for the autonomous manipulation of objects. Especially in industrial environments, robotic systems need to accurately estimate the pose of objects in order to successfully perform picking, placing or assembly tasks. However, the characteristics of industrial objects often cause difficulties for clas
Although border politics have been given much theoretical attention in recent years, empirical studies of identity construction among border police officers are less common. In 2014, a two-year collaborative project partly funded by the EU was initiated in order to increase international collaboration between border police officers in the Baltic Sea area. The participating organizations were borde
For many polar organic micropollutants, biotransformation by activated sludge microorganisms is a major removal process during wastewater treatment. However, our current understanding of how wastewater treatment operations influence microbial communities and their micropollutant biotransformation potential is limited, leaving major parts of observed variability in biotransformation rates across tr
A gardener in Småland, southeastern Sweden, tells that her father cultivated a double daylily, Hemerocallis fulva, with variegated leaves in Stockholm in the mid 20th century. When she moved to Småland, 45 years ago, she brought a piece of his plant with her, and later on she has spread the plant to others. This daylily, known as "Kwanso Variegata", was first found in Japan in 1776, and since then
We describe the iDO serious game developed during implementation of the Innovative Digital Training Opportunities on Dementia for Direct Care Workers (IDO) project. The project targets formal and informal caregivers of persons with dementia in order to improve caregiver knowledge and competences skills with a non-traditional source of training. This paper describes the steps faced to define the iD
In this study, we examined the evolutionary outcome of and interplay between historic isolation and current selection pressures on traits more or less closely connected to fitness in the Pearly Heath butterfly (Coenonympha arcania) across its range in Europe. We hypothesized that a trait mean is more related to historic events if it has low connection to fitness, while a trait more closely connect
Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function. To improve the clinical treatment strategies, experimental models are used to systematically examine the mechanisms behind nerve regeneration and assess the improvement of nerve regeneration by introduction
Although the literature on the Maillard reaction in infant formulas is extensive, most studies have focused on model systems, and in only a few cases on real food systems. Therefore, the objective of the present study was to determine the status of the Maillard reaction, both the early and advanced phases, in a variety of commercial infant formulas available on the Swedish market. Ten powder and l
The artificial replaced hip joint represents the major success story in orthopedic surgery in the twentieth century; there is much interest in extending research on hip joint even further. The stress distribution in the different bone tissues of a femur is significantly altered after an artificial replacement. Thus, there is a strong need to increase the prosthesis performance considering several
In this work we discuss a gradient plasticity formulation which relies on the introduction of higher-order gradient contributions as additional arguments of the free energy function. These gradients can be interpreted in terms of the local geometrically necessary dislocation density. This gives rise to physically well-motivated kinematic-type hardening models in contrast to purely phenomenological
A full-scale membrane bioreactor (MBR) with ultrafiltration, followed by granular activated carbon (GAC), was examined to determine the potential of reusing treated water as a source of drinking water or for irrigation. The major part of the bacteria removal took place in the MBR, whereas the GAC removed substantial amounts of organic micropollutants. Annual variations in inflow and infiltration r
BACKGROUND: Periampullary cancer is a term for cancers arising in or in close proximity to the pancreas. Pancreatic cancer is the 3rd leading cause of cancer death for both sexes and while surgery is the only option for cure, chemotherapy is given in both the adjuvant and palliative settings. The aim of this study was to investigate any sex and gender differences in patients with pancreatic and ot
